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LEE011 (hydrochloride)

Product Name
LEE011 (hydrochloride)
CAS No.
1211443-80-9
Chemical Name
LEE011 (hydrochloride)
Synonyms
LEE011 HCl;Ribociclib HCl;LEE011 (hydrochloride);Ribociclib (Hydrochloride);D6-Ribociclib hydrochloride;RIBOCICLIB; LEE 011; LEE-011;LEE-011 HCl salt, Ribociclib HCl salt;RIBOCICLIB HYDROCHLORIDE (LEE011 HYDROCHLORIDE);7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-1H-pyrrolo[2,3-d]pyrimidine-6-carboxamide hydrochloride;7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide hydrochloride
CBNumber
CB82682008
Molecular Formula
C23H31ClN8O
Formula Weight
470.99824
MOL File
1211443-80-9.mol
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LEE011 (hydrochloride) Property

storage temp. 
Store at -20°C
solubility 
H2O : 10 mg/mL (21.23 mM; Need ultrasonic)DMSO : 7.69 mg/mL (16.33 mM; Need ultrasonic)
form 
Powder
color 
Off-white to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-2276
Product name
Ribociclibhydrochloride
Purity
99.95%
Packaging
5mg
Price
$72
Updated
2021/12/16
ApexBio Technology
Product number
B1083
Product name
LEE011hydrochloride
Packaging
2mg
Price
$88
Updated
2021/12/16
Biosynth Carbosynth
Product number
FR106415
Product name
Ribociclib HCl
Packaging
10mg
Price
$95
Updated
2021/12/16
ChemScene
Product number
CS-2276
Product name
Ribociclibhydrochloride
Purity
99.95%
Packaging
10mg
Price
$96
Updated
2021/12/16
ApexBio Technology
Product number
B1083
Product name
LEE011hydrochloride
Packaging
5mg
Price
$156
Updated
2021/12/16
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LEE011 (hydrochloride) Chemical Properties,Usage,Production

Uses

Ribociclib hydrochloride (LEE011 hydrochloride) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.

in vivo

CB17 immunodeficient mice bearing BE2C, NB-1643 (MYCN amplified, sensitive in vitro), or EBC1 (non-amplified, resistant in vitro) xenografts are treated once daily for 21 days with Ribociclib (LEE011; 200 mg/kg) or with a vehicle control. This dosing strategy is well tolerated, as no weight loss or other signs of toxicity are observed in any of the xenograft models. Tumor growth is significantly delayed throughout the 21 days of treatment in mice harboring the BE2C or 1643 xenografts (both, p<0.0001), although growth resumed post-treatment[2].

IC 50

CDK4: 10 nM (IC50); CDK6: 39 nM (IC50)

References

[1] VanArsdale T, et al. Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment. Clin Cancer Res. 2015 Jul 1;21(13):2905-10. DOI:10.1158/1078-0432.CCR-14-0816
[2] Rader J, et al. Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma. Clin Cancer Res. 2013 Nov 15;19(22):6173-82. DOI:10.1158/1078-0432.CCR-13-1675

LEE011 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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LEE011 (hydrochloride) Suppliers

China 78 India 2 United States 9 Global 89
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
Suzhou Carbonwell Pharma-Tech Co., Ltd
Tel
0512-0512-88981216 13776013740
Email
1320558046@qq.com
Country
China
ProdList
72
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58
Suzhou yacoo science co.,Ltd
Tel
0512-87182056 18013166090
Fax
0512-87182056
Email
lingling.qi@yacoo.com.cn
Country
China
ProdList
6295
Advantage
60
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
Advantage
58
Intelligence Pharm Science(Shanghai) Co., Ltd.
Tel
021-57898186
Fax
021-37699262
Country
China
ProdList
449
Advantage
55
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
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View Lastest Price from LEE011 (hydrochloride) manufacturers

Career Henan Chemical Co
Product
LEE011 (hydrochloride) 1211443-80-9
Price
US $1.00/KG
Min. Order
1KG
Purity
85.0-99.8%
Supply Ability
200kgs
Release date
2020-01-16

1211443-80-9, LEE011 (hydrochloride)Related Search:

tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate LEE011 (succinate) Ribociclib 5-(2-Fluoro-3-methoxyphenyl)-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-2,4(1H,3H)-pyrimidinedione 1,4-BenzenediaMine, N1-[2-(diMethylaMino)ethyl]-5-Methoxy-N1-Methyl-N4-[4-(1-Methyl-1H-indol-3-yl)-2-pyriMidinyl]-2-nitro- 1-(2-FLUORO-6-(TRIFLOROMETHYL)BENZYL)UREA Cholan-24-oic acid,6-ethyl-3-hydroxy-7-oxo-,(3α,5β,6β)-

  • LEE011 (hydrochloride)
  • 7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide hydrochloride (1:1)
  • LEE-011 HCl salt, Ribociclib HCl salt
  • Ribociclib (Hydrochloride)
  • Ribociclib HCl
  • LEE011 HCl
  • 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide hydrochloride
  • RIBOCICLIB HYDROCHLORIDE (LEE011 HYDROCHLORIDE)
  • RIBOCICLIB; LEE 011; LEE-011
  • 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-1H-pyrrolo[2,3-d]pyrimidine-6-carboxamide hydrochloride
  • D6-Ribociclib hydrochloride
  • 1211443-80-9
  • C23H31ClN8O
  • C23H30N8OHCl
  • C23H30N8OClH