Molidustat(BAY 85-3934)
- Product Name
- Molidustat(BAY 85-3934)
- CAS No.
- 1154028-82-6
- Chemical Name
- Molidustat(BAY 85-3934)
- Synonyms
- CS-1728;Somatoprim;MOLIDUSTAT;BAY 85-3934;Molidustat(BAY 85-3934);BAY 85-3934;BAY-85-3934;2-(6-morpholin-4-ylpyrimidin-4-yl)-4-(triazol-1-yl)-1H-pyrazol-3-one;2-(6-morpholinopyrimidin-4-yl)-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-3(2H)-one;1,2-dihydro-2-[6-(4-morpholinyl)-4-pyrimidinyl]-4-(1H-1,2,3-triazol-1-yl)-3H-pyrazol-3-one;2-[6-(4-Morpholinyl)-4-pyrimidinyl]-4-(1H-1,2,3-triazol-1-yl)-1,2-dihydro-3H-pyrazol-3-one
- CBNumber
- CB72729607
- Molecular Formula
- C13H14N8O2
- Formula Weight
- 314.3
- MOL File
- 1154028-82-6.mol
Molidustat(BAY 85-3934) Property
- Boiling point:
- 589.2±60.0 °C(Predicted)
- Density
- 1.67±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- insoluble in EtOH; insoluble in H2O; ≥5.68 mg/mL in DMF
- form
- solid
- pka
- 5.38±0.37(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H360May damage fertility or the unborn child
H372Causes damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P314Get medical advice/attention if you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 15297
- Product name
- BAY 85-3934
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $33
- Updated
- 2024/03/01
- Product number
- 15297
- Product name
- BAY 85-3934
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $137
- Updated
- 2024/03/01
- Product number
- 15297
- Product name
- BAY 85-3934
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $223
- Updated
- 2024/03/01
- Product number
- 15297
- Product name
- BAY 85-3934
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $396
- Updated
- 2024/03/01
- Product number
- CS-4046
- Product name
- Molidustat
- Purity
- 99.26%
- Packaging
- 50mg
- Price
- $400
- Updated
- 2021/12/16
Molidustat(BAY 85-3934) Chemical Properties,Usage,Production
Description
Hypoxia-inducible factor (HIF) is the major transcription factor involved in erythropoietin gene expression. Because oxygen-
in vitro
the ic50 values were found to be dependent on the 2-oxoglutarate concentration in the reaction buffer. by lowering the 2-oxoglutarate concentration from 20 μm to 0.3 μm, the potency of the test compound increased up to 10-fold. variation of the concentrations of fe2+ and ascorbate in the reaction buffer by factors of 30 and 200, respectively, did not alter the potency of the inhibitor by more than 2-fold [1].
in vivo
in repeat dosing of bay 85-3934, hemoglobin levels were increased compared with animals in vehicle group, while endogenous epo remained within the normal physiological range. bay 85-3934 therapy was also effective in the treatment of renal anemia in rats with impaired kidney function and, unlike treatment with rhepo, resulted in normalization of hypertensive blood pressure in a rat model of ckd [1].
IC 50
480 nm, 280 nm, and 450 nm for phd1, phd2, and phd3, respectively.
References
[1] flamme i, oehme f, ellinghaus p, jeske m, keldenich j, thuss u. mimicking hypoxia to treat anemia: hif-stabilizer bay 85-3934 (molidustat) stimulates erythropoietin production without hypertensive effects. plos one. 2014 nov 13;9(11):e111838.
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View Lastest Price from Molidustat(BAY 85-3934) manufacturers
- Product
- Molidustat ;BAY85-3934 1154028-82-6
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 100kgs
- Release date
- 2021-05-24
- Product
- Molidustat 1154028-82-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-23