2-(N-(5-chloro-2-Methylphenyl)MethylsulfonaMido)-N-(2,6-difluorophenyl)acetaMide
- Product Name
- 2-(N-(5-chloro-2-Methylphenyl)MethylsulfonaMido)-N-(2,6-difluorophenyl)acetaMide
- CAS No.
- 708219-39-0
- Chemical Name
- 2-(N-(5-chloro-2-Methylphenyl)MethylsulfonaMido)-N-(2,6-difluorophenyl)acetaMide
- Synonyms
- FPH1;CS-2645;BRD-6125;FPH1(BRD-6125);FPH1;BRD-6125;BRD 6125;BRD6125;inhibit,FPH1,BRD6125,BRD 6125,FPH 1,FPH-1,Inhibitor;2-(N-(5-chloro-2-Methylphenyl)MethylsulfonaMido)-N-(2,6-difluorophenyl)acetaMide;2-[(5-Chloro-2-methylphenyl)(methylsulfonyl)amino]-N-(2,6-difluorophenyl)-acetamide;Acetamide, 2-[(5-chloro-2-methylphenyl)(methylsulfonyl)amino]-N-(2,6-difluorophenyl)-
- CBNumber
- CB72729652
- Molecular Formula
- C16H15ClF2N2O3S
- Formula Weight
- 388.82
- MOL File
- 708219-39-0.mol
2-(N-(5-chloro-2-Methylphenyl)MethylsulfonaMido)-N-(2,6-difluorophenyl)acetaMide Property
- Density
- 1.480±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO: soluble20mg/mL, clear
- pka
- 10.87±0.70(Predicted)
- form
- powder
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0827
- Product name
- FPH1
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $118
- Updated
- 2024/03/01
- Product number
- SML0827
- Product name
- FPH1
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $479
- Updated
- 2024/03/01
- Product number
- 21804
- Product name
- BRD6125
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 21804
- Product name
- BRD6125
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $96
- Updated
- 2024/03/01
- Product number
- 21804
- Product name
- BRD6125
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $143
- Updated
- 2024/03/01
2-(N-(5-chloro-2-Methylphenyl)MethylsulfonaMido)-N-(2,6-difluorophenyl)acetaMide Chemical Properties,Usage,Production
Uses
2-(N-(5-Chloro-2-methylphenyl)methylsulfonamido)-N-(2,6-difluorophenyl)acetamide is a small molecule that enhances hepatocyte functions and promotes the differentiation if induced pluripotent stem cell-derived hepatocytes towards a more mature phenotype than what was previously obtainable.
Biological Activity
fph1 is a small molecule that promotes the functional proliferation of primary hepatocytes [1].fph1 belongs to the functional proliferation hits which are screened out by their ability to permit renewable sourcing of functional human hepatocytes. this ability of fph1 is not dependent on the donors of the hepatocytes. it has been found that fph1 was active against the primary human hepatocytes from six cell sources of genetically diverse individuals. besides that, fph1 can affect the hepatocyte functions with promoting albumin secretion during the differentiation of ips cells into iheps. moreover, treatment of fph1 also resulted in the increase of cyp3a4 levels and the decrease of afp secretion [1].
References
[1] shan j, schwartz r e, ross n t, et al. identification of small molecules for human hepatocyte expansion and ips differentiation. nature chemical biology, 2013.
2-(N-(5-chloro-2-Methylphenyl)MethylsulfonaMido)-N-(2,6-difluorophenyl)acetaMide Preparation Products And Raw materials
Raw materials
Preparation Products
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