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4-chloro- Benzo[b]thiophene

Product Name
4-chloro- Benzo[b]thiophene
CAS No.
66490-33-3
Chemical Name
4-chloro- Benzo[b]thiophene
Synonyms
4-Chlorobenzothiophene;4-chloro-1-benzothiophene;4-chloro- Benzo[b]thiophene;Benzo[b]thiophene, 4-chloro-;4-chloro- Benzo[b]thiophene ISO 9001：2015 REACH
CBNumber
CB72730773
Molecular Formula
C8H5ClS
Formula Weight
168.64
MOL File
66490-33-3.mol
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4-chloro- Benzo[b]thiophene Property

Melting point:
81-82 °C
Boiling point:
0.8 °C(Press: 155-165 Torr)
Density 
1.349±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Acetone (Slightly), Chloroform (Slightly)
form 
Clear Light Yellow Oil to White to Light Yellow Semi-Solid
Appearance
Colorless to light yellow Liquid
InChI
InChI=1S/C8H5ClS/c9-7-2-1-3-8-6(7)4-5-10-8/h1-5H
InChIKey
YGYUMNQONHLLNC-UHFFFAOYSA-N
SMILES
C12=CC=CC(Cl)=C1C=CS2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C364180
Product name
4-Chlorobenzothiophene
Packaging
500mg
Price
$50
Updated
2021/12/16
TRC
Product number
C364180
Product name
4-Chlorobenzothiophene
Packaging
1g
Price
$80
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC146216
Product name
4-Chlorobenzothiophene
Packaging
1g
Price
$54.6
Updated
2021/12/16
AK Scientific
Product number
6517CT
Product name
4-Chlorobenzo[b]thiophene
Packaging
5g
Price
$146
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC146216
Product name
4-Chlorobenzothiophene
Packaging
5G
Price
$175
Updated
2021/12/16
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4-chloro- Benzo[b]thiophene Chemical Properties,Usage,Production

Uses

4-Chlorobenzothiophene is an intermediate used to prepare 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism.

Synthesis

23967-57-9

66490-33-3

General procedure for the synthesis of 4-chlorobenzo[b]thiophene from 4-chlorobenzo[b]thiophene-2-carboxylic acid: a mixture of 2-carboxy-4-chlorobenzo[b]thiophene (50.00 g), 1,3-dimethyl-2-imidazolidinone (DMI; 200 ml) and 1,8-diazabicyclo[5.4.0]undec-7-ene (140.7 ml) was prepared by heating and stirring a mixture of 1,8-diazabicyclo[5.4.0]undec-7-ene (140.7 ml) at 160- 195 °C for 6 hours with heating and stirring. After completion of the reaction, the mixture was cooled to 10°C and then slowly added to 3N hydrochloric acid (350 ml) pre-cooled to 10°C. The reaction mixture was extracted with toluene (500 ml) followed by washing the toluene layer sequentially with 3N hydrochloric acid, water, aqueous sodium bicarbonate solution, water, brine and water. After completion of washing, the toluene layer was concentrated to give 4-chlorobenzo[b]thiophene. Yield: 36.78 g. NMR hydrogen spectrum (DMSO-d6) data were as follows: δ 7.38 (1H, t, J = 8.4 Hz), 7.51 (1H, dd, J = 5.5,0.8 Hz), 7.48 (1H, dd, J = 7.7,0.9 Hz), 7.94 (1H, dd, J = 5.5,0.4 Hz), 8.02 (1H. dt, J = 8.0,0.9Hz).

References

[1] Tetrahedron Letters, 2004, vol. 45, # 52, p. 9645 - 9647
[2] Patent: WO2013/15456, 2013, A1. Location in patent: Page/Page column 41; 42

4-chloro- Benzo[b]thiophene Preparation Products And Raw materials

Raw materials

Preparation Products

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4-chloro- Benzo[b]thiophene Suppliers

China 146 India 4 United Kingdom 1 United States 4 Global 155
Chengdu Aofan Pharmtech Co.,Ltd
Tel
15281070185; 13038283958
Email
2865097598@qq.com
Country
China
ProdList
111
Advantage
55
Chongqing Xingcan Pharmaceutical Technology Co., Ltd.
Tel
023-13650506873 19923294409
Email
xingcanyaoye@sina.com
Country
China
ProdList
1604
Advantage
58
Bayee Biotech (Anqing) Co., Ltd.
Tel
0556-5032306 18917961636
Email
wtx@bayeebio.com
Country
China
ProdList
239
Advantage
61
Tongchuang Pharma(Suzhou). Co., Ltd.
Tel
0512-63263366 18912765016
Fax
0512-6326 3366
Email
tongtf110@sina.com
Country
China
ProdList
993
Advantage
62
Sichuan Fanzhijian Biomedical Technology Co., Ltd
Tel
15281070185
Email
2865097598@qq.com
Country
China
ProdList
898
Advantage
58
Gansu Haotian PharmaTech Co.,Ltd.
Tel
17789447501
Email
zhuanxiajiang@haotianpharm.com
Country
China
ProdList
202
Advantage
58
TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD.
Tel
022-60189726 18812034280
Fax
86-22-60979672
Email
188120342808@163.com
Country
China
ProdList
142
Advantage
61
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
Tianjin Branch Chong pharmaceutical intermediates Co., Ltd.
Tel
022-60116533 13207668525
Fax
022-60979672
Email
saleskc@scipharmacn.com
Country
China
ProdList
603
Advantage
58
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
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View Lastest Price from 4-chloro- Benzo[b]thiophene manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
4-Chloro-1-benzothiophene 66490-33-3
Price
US $8.80-2.20/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-27
Henan Aochuang Chemical Co.,Ltd.
Product
4-chloro- Benzo[b]thiophene 66490-33-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-27
Career Henan Chemical Co
Product
4-chloro- Benzo[b]thiophene 66490-33-3
Price
US $2.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200KG
Release date
2018-08-15

66490-33-3, 4-chloro- Benzo[b]thiopheneRelated Search:

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  • 4-chloro- Benzo[b]thiophene
  • Benzo[b]thiophene, 4-chloro-
  • 4-Chlorobenzothiophene
  • 4-chloro-1-benzothiophene
  • 4-chloro- Benzo[b]thiophene ISO 9001：2015 REACH
  • 66490-33-3