NPS-1034

Product Name: NPS-1034
CAS No.: 1221713-92-3
Chemical Name: NPS-1034
Synonyms: NPS-1034;Mer,NPS-1034,Tyro3,c-Met/HGFR,Apoptosis,Axl,inhibit,TAM Receptor,Inhibitor;N-(3-Fluoro-4-((3-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)phenyl)-2-(4-fluorophenyl)-1,5-dimethyl-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxamide;2-(4-Fluorophenyl)-N-[3-fluoro-4-[(3-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,3-dihydro-1,5-dimethyl-3-oxo-1H-pyrazole-4-carboxamide;1H-Pyrazole-4-carboxamide, 2-(4-fluorophenyl)-N-[3-fluoro-4-[(3-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,3-dihydro-1,5-dimethyl-3-oxo-
CBNumber: CB72731109
Molecular Formula: C31H23F2N5O3
Formula Weight: 551.54
MOL File: 1221713-92-3.mol

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NPS-1034 Property

Density: 1.416±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: crystalline solid
pka: 11.05±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19627
Product name: NPS-1034
Purity: ≥95%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 19627
Product name: NPS-1034
Purity: ≥95%
Packaging: 5mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 19627
Product name: NPS-1034
Purity: ≥95%
Packaging: 10mg
Price: $266
Updated: 2024/03/01

Cayman Chemical

Product number: 19627
Product name: NPS-1034
Purity: ≥95%
Packaging: 25mg
Price: $530
Updated: 2024/03/01

ApexBio Technology

Product number: B6006
Product name: NPS-1034
Packaging: 100mg
Price: $1071
Updated: 2021/12/16

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NPS-1034 Chemical Properties,Usage,Production

Biological Activity

nps-1034 is a met inhibitor with ic50 of 4 nmol/l [1].the hepatocyte growth factor receptor tyrosine kinase met is required for various morphogenetic events and controls the malignant progression of many human tumors. in various advanced human cancer, gene amplification can deregulate met [1].in mkn45 and snu638 cell lines highly expressing the met gene and p-met (phosphorylated met), ic50 values of nps-1034 to inhibit cell viability were 112.7 and 190.3 nmol, respectively. in ags, katoiii, nci-n87, mkn1, mkn28, and mkn74 cells, the ic50 values of nps-1034 to inhibit cell viability ranged from 1 μmol to more than 10 μmol. in mkn45 cells, treatment with nps-1034 dramatically decreased met phosphorylation (activation). but in mkn28 cells, met phosphorylation was not dramatically decreased. this meant that the anti-proliferative effect of nps-1034 was resulted from its inhibition of p-met [1].in nude mice bearing mkn45 tumors, after the diameter of mkn45 tumors had reached about 180 mm3, nps-1034 at a dose of 30 mg/kg or pbs as vehicle was orally administered once daily for 25 days. it was found that nps-1034 inhibited the proliferation of tumors highly expressing p-met. without drug treatment, neovascularization appeared in tumors in nude mice when the tumor volume was >150 mm3. nps-1034 treatment clearly decreased the vascularization of the tumors in nude mice [1].

References

[1]. shin js, hong sw, moon jh, et al. nps-1034, a novel met inhibitor, inhibits the activated met receptor and its constitutively active mutants. investigational new drugs, 2014, 32(3): 389-399.

NPS-1034 Preparation Products And Raw materials

Raw materials

Preparation Products

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NPS-1034 Suppliers

China 45 India 1 United States 7 Global 53

CEG Chemical Science&Technology Co., Ltd.

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ShangHai Caerulum Pharma Discovery Co., Ltd.

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Amadis Chemical Company Limited

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Shanghai Biopharmaleader Co., Ltd.

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Angel Pharmatech, Ltd.

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Guangzhou Tomums Life Science Co., Ltd.

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Taizhou Crene Biotechnology Co. Ltd.

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TargetMol Chemicals Inc.

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InvivoChem

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1221713-92-3, NPS-1034Related Search:

4-Aminodiphenylamine N-Methylbenzamide

NPS-1034

2-(4-Fluorophenyl)-N-[3-fluoro-4-[(3-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,3-dihydro-1,5-dimethyl-3-oxo-1H-pyrazole-4-carboxamide

1H-Pyrazole-4-carboxamide, 2-(4-fluorophenyl)-N-[3-fluoro-4-[(3-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,3-dihydro-1,5-dimethyl-3-oxo-

Mer,NPS-1034,Tyro3,c-Met/HGFR,Apoptosis,Axl,inhibit,TAM Receptor,Inhibitor

N-(3-Fluoro-4-((3-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)phenyl)-2-(4-fluorophenyl)-1,5-dimethyl-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxamide

1221713-92-3

C31H23F2N5O3