NPS-1034

Product Name: NPS-1034
CAS No.: 1221713-92-3
Chemical Name: NPS-1034
Synonyms: NPS-1034;Mer,NPS-1034,Tyro3,c-Met/HGFR,Apoptosis,Axl,inhibit,TAM Receptor,Inhibitor;N-(3-Fluoro-4-((3-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)phenyl)-2-(4-fluorophenyl)-1,5-dimethyl-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxamide;2-(4-Fluorophenyl)-N-[3-fluoro-4-[(3-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,3-dihydro-1,5-dimethyl-3-oxo-1H-pyrazole-4-carboxamide;1H-Pyrazole-4-carboxamide, 2-(4-fluorophenyl)-N-[3-fluoro-4-[(3-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,3-dihydro-1,5-dimethyl-3-oxo-
CBNumber: CB72731109
Molecular Formula: C31H23F2N5O3
Formula Weight: 551.54
MOL File: 1221713-92-3.mol

More

Less

NPS-1034 Property

Density: 1.416±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: crystalline solid
pka: 11.05±0.70(Predicted)
color: White to off-white

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 19627
Product name: NPS-1034
Purity: ≥95%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 19627
Product name: NPS-1034
Purity: ≥95%
Packaging: 5mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 19627
Product name: NPS-1034
Purity: ≥95%
Packaging: 10mg
Price: $266
Updated: 2024/03/01

Cayman Chemical

Product number: 19627
Product name: NPS-1034
Purity: ≥95%
Packaging: 25mg
Price: $530
Updated: 2024/03/01

ChemScene

Product number: CS-0019643
Product name: NPS-1034
Purity: ≥98.0%
Packaging: 5mg
Price: $84
Updated: 2021/12/16

More

Less

NPS-1034 Chemical Properties,Usage,Production

Biological Activity

nps-1034 is a met inhibitor with ic50 of 4 nmol/l [1].the hepatocyte growth factor receptor tyrosine kinase met is required for various morphogenetic events and controls the malignant progression of many human tumors. in various advanced human cancer, gene amplification can deregulate met [1].in mkn45 and snu638 cell lines highly expressing the met gene and p-met (phosphorylated met), ic50 values of nps-1034 to inhibit cell viability were 112.7 and 190.3 nmol, respectively. in ags, katoiii, nci-n87, mkn1, mkn28, and mkn74 cells, the ic50 values of nps-1034 to inhibit cell viability ranged from 1 μmol to more than 10 μmol. in mkn45 cells, treatment with nps-1034 dramatically decreased met phosphorylation (activation). but in mkn28 cells, met phosphorylation was not dramatically decreased. this meant that the anti-proliferative effect of nps-1034 was resulted from its inhibition of p-met [1].in nude mice bearing mkn45 tumors, after the diameter of mkn45 tumors had reached about 180 mm3, nps-1034 at a dose of 30 mg/kg or pbs as vehicle was orally administered once daily for 25 days. it was found that nps-1034 inhibited the proliferation of tumors highly expressing p-met. without drug treatment, neovascularization appeared in tumors in nude mice when the tumor volume was >150 mm3. nps-1034 treatment clearly decreased the vascularization of the tumors in nude mice [1].

References

[1]. shin js, hong sw, moon jh, et al. nps-1034, a novel met inhibitor, inhibits the activated met receptor and its constitutively active mutants. investigational new drugs, 2014, 32(3): 389-399.

NPS-1034 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

NPS-1034 Suppliers

China 45 India 1 United States 7 Global 53

CEG Chemical Science&Technology Co., Ltd.

Tel: Mobile:13665161512
Fax: +86-510-68873513
Country: China
ProdList: 1785
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3466
Advantage: 58

Shanghai CP Pharmaceutical Technology Co., Ltd.

Tel: 18221530285
Fax: -
Country: China
ProdList: 489
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shanghai Biopharmaleader Co., Ltd.

Tel: +86 18721201413
Fax: +86 (21) 5775-8967
Email: sales@biopharmaleader.com
Country: China
ProdList: 1720
Advantage: 58

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3251
Advantage: 58

Guangzhou Tomums Life Science Co., Ltd.

Tel: 020-31155029 18902330969
Fax: 020-31155029
Email: sales@tomums.cn
Country: China
ProdList: 4696
Advantage: 58

Taizhou Crene Biotechnology Co. Ltd.

Tel: +86-0576-88813233 +86-13396860566
Email: sales@pharm-intermediates.com
Country: China
ProdList: 1990
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

1221713-92-3, NPS-1034Related Search:

4-Aminodiphenylamine N-Methylbenzamide

NPS-1034

2-(4-Fluorophenyl)-N-[3-fluoro-4-[(3-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,3-dihydro-1,5-dimethyl-3-oxo-1H-pyrazole-4-carboxamide

1H-Pyrazole-4-carboxamide, 2-(4-fluorophenyl)-N-[3-fluoro-4-[(3-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,3-dihydro-1,5-dimethyl-3-oxo-

Mer,NPS-1034,Tyro3,c-Met/HGFR,Apoptosis,Axl,inhibit,TAM Receptor,Inhibitor

N-(3-Fluoro-4-((3-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)phenyl)-2-(4-fluorophenyl)-1,5-dimethyl-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxamide

1221713-92-3

C31H23F2N5O3