1-Chloro-4-Methylisoquinoline

Product Name: 1-Chloro-4-Methylisoquinoline
CAS No.: 24188-78-1
Chemical Name: 1-Chloro-4-Methylisoquinoline
Synonyms: 1-Chloro-4-Methylisoquinoline;Isoquinoline, 1-chloro-4-methyl-
CBNumber: CB72731543
Molecular Formula: C10H8ClN
Formula Weight: 177.63
MOL File: 24188-78-1.mol

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1-Chloro-4-Methylisoquinoline Property

Boiling point:: 314.1±22.0 °C(Predicted)
Density: 1.225±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 2.47±0.31(Predicted)
Appearance: White to yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 1549DA
Product name: 1-Chloro-4-methylisoquinoline
Packaging: 250mg
Price: $336
Updated: 2021/12/16

AK Scientific

Product number: 1549DA
Product name: 1-Chloro-4-methylisoquinoline
Packaging: 1g
Price: $743
Updated: 2021/12/16

Chemenu

Product number: CM143593
Product name: 1-chloro-4-methylisoquinoline
Purity: 97%
Packaging: 5g
Price: $1216
Updated: 2021/12/16

Crysdot

Product number: CD11160272
Product name: 1-Chloro-4-methylisoquinoline
Purity: 97%
Packaging: 5g
Price: $1287
Updated: 2021/12/16

Alichem

Product number: 24188781
Product name: 1-Chloro-4-methylisoquinoline
Packaging: 5g
Price: $1390.64
Updated: 2021/12/16

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1-Chloro-4-Methylisoquinoline Chemical Properties,Usage,Production

Synthesis

77077-83-9

24188-78-1

Step 2: Dissolve 4-methyl-2H-isoquinolin-1-one (4.8 g) in phosphorous trichloride (50 mL) and heat to reflux for 3 hours. Upon completion of the reaction, it was cooled to room temperature and concentrated under reduced pressure. The residue was treated with 5 N aqueous sodium hydroxide and subsequently extracted with dichloromethane. The organic layers were combined, washed with saturated brine and dried over anhydrous magnesium sulfate. After filtration, the filtrate was concentrated under reduced pressure and the resulting crude product was purified by Biotage fast chromatography, the eluent being a hexane solution of 5% ethyl acetate to give 4.8 g (90% yield) of the target product, 1-chloro-4-methylisoquinoline, as a white solid. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 2.59 (s, 3H), 7.68 (t, J = 7.70 Hz, 1H), 7.78 (m, 1H), 7.94 (d, J = 8.31 Hz, 1H), 8.11 (s, 1H), 8.35 (d, J = 8.31 Hz, 1H).

References

[1] Patent: US2006/183694, 2006, A1. Location in patent: Page/Page column 73-74
[2] Patent: WO2003/99274, 2003, A1. Location in patent: Page 324-325
[3] Patent: US2007/99825, 2007, A1. Location in patent: Page/Page column 62
[4] Patent: US2008/107623, 2008, A1. Location in patent: Page/Page column 57
[5] Patent: US2008/107624, 2008, A1. Location in patent: Page/Page column 60

1-Chloro-4-Methylisoquinoline Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Chloro-4-Methylisoquinoline Suppliers

China 41 India 1 United States 3 Global 45

ShangHai AmK Pharmaceutical Technology Co., Ltd.

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1-Chloro-4-Methylisoquinoline

Isoquinoline, 1-chloro-4-methyl-

24188-78-1