6-Bromo-1-chloroisoquinoline

Product Name: 6-Bromo-1-chloroisoquinoline
CAS No.: 205055-63-6
Chemical Name: 6-Bromo-1-chloroisoquinoline
Synonyms: SKL322;6-Bromo-1-chL;6-Bromo-2-chloroisoquinoline;1-Chloro-6-bromoisoquinoline;6-BROMO-1-CHLORO-ISOQUINOLINE;Isoquinoline, 6-bromo-1-chloro-;1-chloro -6-broMideisoquinoline;6-Bromo-1-chloroisoquinoline ISO 9001：2015 REACH;6-Bromo-1-chloroisoquinoline 1-Chloro-6-bromoisoquinoline
CBNumber: CB4109550
Molecular Formula: C9H5BrClN
Formula Weight: 242.5
MOL File: 205055-63-6.mol

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6-Bromo-1-chloroisoquinoline Property

Boiling point:: 349.5±22.0 °C(Predicted)
Density: 1.673
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 1.48±0.38(Predicted)
form: powder
color: Light yellow to yellow
InChI: InChI=1S/C9H5BrClN/c10-7-1-2-8-6(5-7)3-4-12-9(8)11/h1-5H
InChIKey: VOAHGGQULSSGQW-UHFFFAOYSA-N
SMILES: C1(Cl)C2=C(C=C(Br)C=C2)C=CN=1

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Safety

Hazard Codes: T
Risk Statements: 25-38-41
Safety Statements: 26-45
RIDADR: UN2811
HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B682515
Product name: 6-Bromo-1-chloroisoquinoline
Packaging: 250mg
Price: $95
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB42058
Product name: 6-Bromo-1-chloroisoquinoline
Packaging: 250mg
Price: $100
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: CAPOB11655
Product name: 6-Bromo-1-chloroisoquinoline
Purity: 95%
Packaging: 1g
Price: $88
Updated: 2021/12/16

Matrix Scientific

Product number: 070409
Product name: 6-Bromo-1-chloroisoquinoline
Purity: 97%
Packaging: 1g
Price: $89
Updated: 2021/12/16

Apolloscientific

Product number: OR300053
Product name: 6-Bromo-1-chloroisoquinoline
Packaging: 1g
Price: $73
Updated: 2021/12/16

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6-Bromo-1-chloroisoquinoline Chemical Properties,Usage,Production

Chemical Properties

Yellow solid

Uses

6-Bromo-1-chloroisoquinoline has been used as a reactant in the preparation of phenylimidazoles as Smoothened antagonists.

Synthesis

N-oxide 6-bromoisoquinoline (1.82 g, 8.12 mmol) was dissolved in dry DCM (80 mL), POCl3 (1.12 ml, 1.5 eq) was added dropwise at RT. The reaction was heated to 45°C for 2 hours. After cooling down the reaction to RT, DCM and excessive POCl3 were removed under the vacuum. The crude was re-dissolved into 100mL DCM and was washed by saturated Na2CO3, water and brine. The separated organic layer was dried over Na2SO4, and concentrated to give brown solid. The crude was purified by flash column using 2% MeOH in DCM to get the pale yellow solid 6-Bromo-1-chloroisoquinoline.

References

[1] European Journal of Organic Chemistry, 2016, vol. 2016, # 8, p. 1606 - 1611
[2] Patent: WO2013/185353, 2013, A1. Location in patent: Page/Page column 27
[3] Patent: WO2014/165232, 2014, A1. Location in patent: Paragraph 0202; 0203
[4] Patent: US2015/119387, 2015, A1. Location in patent: Paragraph 0203; 0204
[5] Patent: JP2017/95498, 2017, A. Location in patent: Paragraph 0122; 0123

6-Bromo-1-chloroisoquinoline Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Bromo-1-chloroisoquinoline Suppliers

China 191 Germany 1 India 5 United Kingdom 2 United States 18 Global 217

Shanghai Dano Pharmaceutical Co., LTD(China)

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Email: sales@chemsdano.com
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Shanghai Jinsheng Pharmaceutical Co., Ltd.

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Country: China
ProdList: 356
Advantage: 58

PureChemland Co.,Ltd.

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J & K SCIENTIFIC LTD.

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Fax: 86-10-82849933
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Country: China
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future industrial shanghai co., ltd

Tel: 400-0066400 13621662912
Fax: 021-55660885
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ProdList: 1995
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Energy Chemical

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Country: China
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Advantage: 61

Jia Xing Isenchem Co.,Ltd

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ProdList: 9310
Advantage: 66

Shangchem Co., Ltd.

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Accela ChemBio Co.,Ltd.

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ZEROSCHEM.CO.,LTD.

Tel: 10-61256048 13810278579
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View Lastest Price from 6-Bromo-1-chloroisoquinoline manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 6-Bromo-1-chloroisoquinoline 205055-63-6
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-24

Hebei Yanxi Chemical Co., Ltd.

Product: 6-Bromo-1-chloroisoquinoline 205055-63-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-11-27

Career Henan Chemical Co

Product: 6-Bromo-1-chloroisoquinoline 205055-63-6
Price: US $8.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10tons
Release date: 2018-12-25

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