7-Bromoisoquinoline
- Product Name
- 7-Bromoisoquinoline
- CAS No.
- 58794-09-5
- Chemical Name
- 7-Bromoisoquinoline
- Synonyms
- isoquinolin-7-amine;7-isoquinoline;7-BROMOISOQUINOLINE;Isoquinoline, 7-bromo-;7-Bromo-2-azanaphthalene;7-Bromoisoquinoline ISO 9001：2015 REACH
- CBNumber
- CB4404794
- Molecular Formula
- C9H6BrN
- Formula Weight
- 208.05
- MOL File
- 58794-09-5.mol
7-Bromoisoquinoline Property
- Melting point:
- 69.0 to 73.0 °C
- Boiling point:
- 312.3±15.0 °C(Predicted)
- Density
- 1.564±0.06 g/cm3(Predicted)
- Flash point:
- 113℃
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 4.62±0.10(Predicted)
- color
- White to Pale Beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 757101
- Product name
- 7-Bromoisoquinoline
- Purity
- 97%
- Packaging
- 1g
- Price
- $112
- Updated
- 2025/07/31
- Product number
- B5071
- Product name
- 7-Bromoisoquinoline
- Purity
- >96.0%(GC)
- Packaging
- 200mg
- Price
- $54
- Updated
- 2025/07/31
- Product number
- B5071
- Product name
- 7-Bromoisoquinoline
- Purity
- >96.0%(GC)
- Packaging
- 1g
- Price
- $214
- Updated
- 2025/07/31
- Product number
- 10007081
- Product name
- 7-Bromoisoquinoline
- Purity
- ≥99%
- Packaging
- 500mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 10007081
- Product name
- 7-Bromoisoquinoline
- Purity
- ≥99%
- Packaging
- 1g
- Price
- $87
- Updated
- 2024/03/01
7-Bromoisoquinoline Chemical Properties,Usage,Production
Description
7-
Chemical Properties
Off-White Solid
Uses
7-Bromoisoquinoline (cas# 58794-09-5) is a compound useful in organic synthesis. It can be used for the preparation of estrone cortistatin analogs via Suzuki-Miyaura coupling. It could also be used for the preparation of pyrazolopyrimidinamine derivatives.
Synthesis
3132-99-8
22483-09-6
58794-09-5
General method: Aminoacetaldehyde dimethyl acetal (3.0 eq.) was added to a solution of m-bromobenzaldehyde (1.0 eq.) in toluene (30 mL). The reaction mixture was refluxed at 120°C (using a Dean-Stark device to remove water). After the feedstock was completely consumed, the reaction mixture was concentrated and the concentrate was redissolved. Concentrated H2SO4 (2 mL) and P2O5 (0.5 mL) were slowly added to the cooled concentrate. Subsequently, the reaction mixture was heated at 160 °C for 30 min, cooled to room temperature, neutralized with 10 M NaOH, extracted with EtOAc, and concentrated to dryness. The residue was purified by fast column chromatography (FCC) to afford 6-bromoisoquinoline (14b, 30 mg, 0.14 mmol, 14% yield) and 7-bromoisoquinoline (14c, 99 mg, 0.47 mmol, 22% yield) [20,21]. Ethyl chloroformate (1.0 eq.) was added dropwise to a DCM solution of isoquinoline 14b or 14c (1.0 eq.) at 0 °C, maintained at temperature and stirred for 30 min, followed by the addition of 2-trimethylsilylthiazole (1.0 eq.). The reaction mixture was stirred at room temperature for 3 hours, concentrated to dryness and the residue was purified by FCC. The purified product was dissolved in benzene (5 mL), o-chloroquinone (1.0 eq.) was added and the reaction mixture was refluxed for 5 hours. Upon completion of the reaction, it was diluted with 5% NaOH (10 mL), extracted by DCM and concentrated to dryness. The final product was purified by FCC to give the target compounds 9b and 9c.
References
[1] Molecules, 2017, vol. 22, # 8,
7-Bromoisoquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 7-Bromoisoquinoline manufacturers
- Product
- 7-Bromoisoquinoline 58794-09-5
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2019-12-25