7-BROMO-1-HYDROXYISOQUINOLINE
- Product Name
- 7-BROMO-1-HYDROXYISOQUINOLINE
- CAS No.
- 223671-15-6
- Chemical Name
- 7-BROMO-1-HYDROXYISOQUINOLINE
- Synonyms
- 7-broMoisoquinolin-1(2H)-one;7-bromoisoquinolin-1-ol;7-Bromoiso;7-Bromoisocarbostyril;7-BroMoisoquinolin-1-one;7-Bromo-1-hydroxyisoquinoL;7-Bromo-1(2H)-isoquinolinone;7-BROMO-1-HYDROXYISOQUINOLINE;1(2H)-Isoquinolinone, 7-bromo-;7-bromo-1-hydroxyisoquinoline 95%
- CBNumber
- CB6267355
- Molecular Formula
- C9H6BrNO
- Formula Weight
- 224.05
- MOL File
- 223671-15-6.mol
7-BROMO-1-HYDROXYISOQUINOLINE Property
- Melting point:
- 248-250°C
- Boiling point:
- 427.5±45.0 °C(Predicted)
- Density
- 1.620±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- solid
- pka
- 12.34±0.20(Predicted)
- color
- Off-white to light yellow
- Water Solubility
- Slightly soluble in water.
- BRN
- 8405244
- InChI
- InChI=1S/C9H6BrNO/c10-7-2-1-6-3-4-11-9(12)8(6)5-7/h1-5H,(H,11,12)
- InChIKey
- DSOKREQUHLPVFR-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C=CC(Br)=C2)C=CN1
Safety
- Hazard Codes
- Xn
- Risk Statements
- 36/37/38-41-37/38-22
- Safety Statements
- 26-36
- WGK Germany
- 3
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 749559
- Product name
- 7-bromo-1-hydroxyisoquinoline
- Purity
- 95%
- Packaging
- 500mg
- Price
- $69.1
- Updated
- 2023/06/20
- Product number
- B677830
- Product name
- 7-Bromoisoquinolin-1(2H)-one
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FB142802
- Product name
- 7-Bromo-1-hydroxyisoquinoline
- Packaging
- 500mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- BP-11869
- Product name
- 7-bromoisoquinolin-1(2H)-one
- Packaging
- 1g
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 4H01-9-25
- Product name
- 7-Bromo-1-hydroxyisoquinoline
- Packaging
- 1g
- Price
- $108
- Updated
- 2021/12/16
7-BROMO-1-HYDROXYISOQUINOLINE Chemical Properties,Usage,Production
Uses
7-Bromo-1-hydroxyisoquinoline acts as a pharmaceutical intermediate. It is also used to prepare 1-amino-4-bromoisoquinoline.
Synthesis
215453-51-3
223671-15-6
7-Bromo-1-chloroisoquinoline (1a, 2.70 g, 11.10 mmol) was used as starting material, which was dissolved in acetic acid (50 mL), followed by the addition of ammonium acetate (1b, 8.50 g, 111.10 mmol). The reaction mixture was placed in an oil bath at 100 °C and the reaction was stirred for 4 hours. After completion of the reaction, the reaction mixture was concentrated to dryness by rotary evaporator. An appropriate amount of water was added to the residue and a white solid precipitated. The solid product was collected by filtration and washed with water to afford 7-bromoisoquinolin-1(2H)-one (1c, 2.7 g, white solid). The crude product was used directly in the subsequent reaction without further purification. Mass spectrum (ESI) m/z: 225.9 [M + 1]+. 1H NMR (400 MHz, CDCl3) δ: 8.55 (d, J = 1.8 Hz, 1H), 7.75 (dd, J = 2.1, 8.5 Hz, 1H), 7.43 (d, J = 8.6 Hz, 1H), 7.14 (d, J = 6.2 Hz, 1H), 6.52 ( d, J = 7.3 Hz, 1H).
References
[1] Chemical Communications, 2018, vol. 54, # 75, p. 10574 - 10577
[2] Patent: EP3042907, 2016, A1. Location in patent: Paragraph 0324; 0325
7-BROMO-1-HYDROXYISOQUINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 7-BROMO-1-HYDROXYISOQUINOLINE manufacturers
- Product
- 7-BROMO-1-HYDROXYISOQUINOLINE 223671-15-6
- Price
- US $10.00/KG
- Min. Order
- 100KG
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2025-03-10
- Product
- 7-BROMO-1-HYDROXYISOQUINOLINE 223671-15-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-31