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7-BROMO-1-HYDROXYISOQUINOLINE

Product Name
7-BROMO-1-HYDROXYISOQUINOLINE
CAS No.
223671-15-6
Chemical Name
7-BROMO-1-HYDROXYISOQUINOLINE
Synonyms
7-broMoisoquinolin-1(2H)-one;7-bromoisoquinolin-1-ol;7-Bromoiso;7-Bromoisocarbostyril;7-BroMoisoquinolin-1-one;7-Bromo-1-hydroxyisoquinoL;7-Bromo-1(2H)-isoquinolinone;7-BROMO-1-HYDROXYISOQUINOLINE;1(2H)-Isoquinolinone, 7-bromo-;7-bromo-1-hydroxyisoquinoline 95%
CBNumber
CB6267355
Molecular Formula
C9H6BrNO
Formula Weight
224.05
MOL File
223671-15-6.mol
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7-BROMO-1-HYDROXYISOQUINOLINE Property

Melting point:
248-250°C
Boiling point:
427.5±45.0 °C(Predicted)
Density 
1.620±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. 
Inert atmosphere,Room Temperature
form 
solid
pka
12.34±0.20(Predicted)
color 
Off-white to light yellow
Water Solubility 
Slightly soluble in water.
BRN 
8405244
InChI
InChI=1S/C9H6BrNO/c10-7-2-1-6-3-4-11-9(12)8(6)5-7/h1-5H,(H,11,12)
InChIKey
DSOKREQUHLPVFR-UHFFFAOYSA-N
SMILES
C1(=O)C2=C(C=CC(Br)=C2)C=CN1
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Safety

Hazard Codes 
Xn
Risk Statements 
36/37/38-41-37/38-22
Safety Statements 
26-36
WGK Germany 
3
HS Code 
2933499090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
749559
Product name
7-bromo-1-hydroxyisoquinoline
Purity
95%
Packaging
500mg
Price
$69.1
Updated
2023/06/20
TRC
Product number
B677830
Product name
7-Bromoisoquinolin-1(2H)-one
Packaging
100mg
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB142802
Product name
7-Bromo-1-hydroxyisoquinoline
Packaging
500mg
Price
$85
Updated
2021/12/16
BroadPharm
Product number
BP-11869
Product name
7-bromoisoquinolin-1(2H)-one
Packaging
1g
Price
$95
Updated
2021/12/16
SynQuest Laboratories
Product number
4H01-9-25
Product name
7-Bromo-1-hydroxyisoquinoline
Packaging
1g
Price
$108
Updated
2021/12/16
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7-BROMO-1-HYDROXYISOQUINOLINE Chemical Properties,Usage,Production

Uses

7-Bromo-1-hydroxyisoquinoline acts as a pharmaceutical intermediate. It is also used to prepare 1-amino-4-bromoisoquinoline.

Synthesis

215453-51-3

223671-15-6

7-Bromo-1-chloroisoquinoline (1a, 2.70 g, 11.10 mmol) was used as starting material, which was dissolved in acetic acid (50 mL), followed by the addition of ammonium acetate (1b, 8.50 g, 111.10 mmol). The reaction mixture was placed in an oil bath at 100 °C and the reaction was stirred for 4 hours. After completion of the reaction, the reaction mixture was concentrated to dryness by rotary evaporator. An appropriate amount of water was added to the residue and a white solid precipitated. The solid product was collected by filtration and washed with water to afford 7-bromoisoquinolin-1(2H)-one (1c, 2.7 g, white solid). The crude product was used directly in the subsequent reaction without further purification. Mass spectrum (ESI) m/z: 225.9 [M + 1]+. 1H NMR (400 MHz, CDCl3) δ: 8.55 (d, J = 1.8 Hz, 1H), 7.75 (dd, J = 2.1, 8.5 Hz, 1H), 7.43 (d, J = 8.6 Hz, 1H), 7.14 (d, J = 6.2 Hz, 1H), 6.52 ( d, J = 7.3 Hz, 1H).

References

[1] Chemical Communications, 2018, vol. 54, # 75, p. 10574 - 10577
[2] Patent: EP3042907, 2016, A1. Location in patent: Paragraph 0324; 0325

7-BROMO-1-HYDROXYISOQUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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7-BROMO-1-HYDROXYISOQUINOLINE Suppliers

China 124 Germany 3 India 3 United Kingdom 6 United States 14 Global 150
Porphyrin Systems
Tel
--
Fax
--
Email
hombrecher@porphyrin-systems.de
Country
Germany
ProdList
444
Advantage
50
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
ABCR GmbH & CO. KG
Tel
--
Fax
--
Email
info@abcr.de
Country
Germany
ProdList
6831
Advantage
75
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View Lastest Price from 7-BROMO-1-HYDROXYISOQUINOLINE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
7-BROMO-1-HYDROXYISOQUINOLINE 223671-15-6
Price
US $10.00/KG
Min. Order
100KG
Purity
99%
Supply Ability
100 mt
Release date
2025-03-10
Career Henan Chemical Co
Product
7-BROMO-1-HYDROXYISOQUINOLINE 223671-15-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2019-12-31

223671-15-6, 7-BROMO-1-HYDROXYISOQUINOLINERelated Search:

7-BROMO-1-METHOXYISOQUINOLINE 7-BROMO-ISOQUINOLIN-1-YLAMINE 7-BROMO-1-CHLOROISOQUINOLINE 7-BROMO-1-METHYL-1H-INDAZOLE METHYL 7-BROMO-1-BENZOTHIOPHENE-2-CARBOXYLATE 6-BROMO-3-HYDROXYISOQUINOLINE 7-BROMO-2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONE 4-BROMO-1-HYDROXYISOQUINOLINE Isocarbostyril 7-BROMO-1-HYDROXYISOQUINOLINE 7-Bromoisoquinoline

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