ChemicalBook > CAS DataBase List > 7-BROMO-1-HYDROXYISOQUINOLINE

7-BROMO-1-HYDROXYISOQUINOLINE

Product Name
7-BROMO-1-HYDROXYISOQUINOLINE
CAS No.
223671-15-6
Chemical Name
7-BROMO-1-HYDROXYISOQUINOLINE
Synonyms
7-broMoisoquinolin-1(2H)-one;7-bromoisoquinolin-1-ol;7-Bromoiso;7-Bromoisocarbostyril;7-BroMoisoquinolin-1-one;7-Bromo-1-hydroxyisoquinoL;7-Bromo-1(2H)-isoquinolinone;7-BROMO-1-HYDROXYISOQUINOLINE;1(2H)-Isoquinolinone, 7-bromo-;7-bromo-1-hydroxyisoquinoline 95%
CBNumber
CB6267355
Molecular Formula
C9H6BrNO
Formula Weight
224.05
MOL File
223671-15-6.mol
More
Less

7-BROMO-1-HYDROXYISOQUINOLINE Property

Melting point:
248-250°C
Boiling point:
427.5±45.0 °C(Predicted)
Density 
1.620±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. 
Inert atmosphere,Room Temperature
form 
solid
pka
12.34±0.20(Predicted)
color 
Off-white to light yellow
Water Solubility 
Slightly soluble in water.
BRN 
8405244
InChI
InChI=1S/C9H6BrNO/c10-7-2-1-6-3-4-11-9(12)8(6)5-7/h1-5H,(H,11,12)
InChIKey
DSOKREQUHLPVFR-UHFFFAOYSA-N
SMILES
C1(=O)C2=C(C=CC(Br)=C2)C=CN1
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
36/37/38-41-37/38-22
Safety Statements 
26-36
WGK Germany 
3
HS Code 
2933499090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
749559
Product name
7-bromo-1-hydroxyisoquinoline
Purity
95%
Packaging
500mg
Price
$69.1
Updated
2023/06/20
TRC
Product number
B677830
Product name
7-Bromoisoquinolin-1(2H)-one
Packaging
100mg
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB142802
Product name
7-Bromo-1-hydroxyisoquinoline
Packaging
500mg
Price
$85
Updated
2021/12/16
BroadPharm
Product number
BP-11869
Product name
7-bromoisoquinolin-1(2H)-one
Packaging
1g
Price
$95
Updated
2021/12/16
SynQuest Laboratories
Product number
4H01-9-25
Product name
7-Bromo-1-hydroxyisoquinoline
Packaging
1g
Price
$108
Updated
2021/12/16
More
Less

7-BROMO-1-HYDROXYISOQUINOLINE Chemical Properties,Usage,Production

Uses

7-Bromo-1-hydroxyisoquinoline acts as a pharmaceutical intermediate. It is also used to prepare 1-amino-4-bromoisoquinoline.

Synthesis

215453-51-3

223671-15-6

7-Bromo-1-chloroisoquinoline (1a, 2.70 g, 11.10 mmol) was used as starting material, which was dissolved in acetic acid (50 mL), followed by the addition of ammonium acetate (1b, 8.50 g, 111.10 mmol). The reaction mixture was placed in an oil bath at 100 °C and the reaction was stirred for 4 hours. After completion of the reaction, the reaction mixture was concentrated to dryness by rotary evaporator. An appropriate amount of water was added to the residue and a white solid precipitated. The solid product was collected by filtration and washed with water to afford 7-bromoisoquinolin-1(2H)-one (1c, 2.7 g, white solid). The crude product was used directly in the subsequent reaction without further purification. Mass spectrum (ESI) m/z: 225.9 [M + 1]+. 1H NMR (400 MHz, CDCl3) δ: 8.55 (d, J = 1.8 Hz, 1H), 7.75 (dd, J = 2.1, 8.5 Hz, 1H), 7.43 (d, J = 8.6 Hz, 1H), 7.14 (d, J = 6.2 Hz, 1H), 6.52 ( d, J = 7.3 Hz, 1H).

References

[1] Chemical Communications, 2018, vol. 54, # 75, p. 10574 - 10577
[2] Patent: EP3042907, 2016, A1. Location in patent: Paragraph 0324; 0325

7-BROMO-1-HYDROXYISOQUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

7-BROMO-1-HYDROXYISOQUINOLINE Suppliers

China 124 Germany 3 India 3 United Kingdom 6 United States 14 Global 150
Shanghai Hong-chuang Pharma Tech Co., Ltd.
Tel
18151128828
Fax
-
Email
hc-sales@foxmail.com
Country
China
ProdList
2647
Advantage
55
Suzhou Dongji Chemical Technology Co., Ltd.
Tel
18516099287
Email
3045383737@qq.com
Country
China
ProdList
230
Advantage
58
Suzhou Sino Rare Chemical Co., Ltd.
Tel
0512-62857507
Fax
+86-512-62857507
Email
sales@sinorarechem.com
Country
China
ProdList
998
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12000
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9309
Advantage
66
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 18971495150;
Email
sales@sun-shinechem.com
Country
China
ProdList
1077
Advantage
64
ZEROSCHEM.CO.,LTD.
Tel
10-61256048 13810278579
Fax
+86 10 61256049
Email
sales@zeroschem.com
Country
China
ProdList
1371
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Shanghai Sheepchem Co., Ltd.
Tel
+86 (21) 6715-7650
Fax
+86 (21) 6715-7651
Email
sheepchem@163.com
Country
China
ProdList
994
Advantage
60
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Anichem Inc.
Tel
0512-69369885
Fax
0512-69369880
Email
sales@anichem.com.cn
Country
China
ProdList
495
Advantage
55
Shanghai ChriChem Co., Ltd.
Tel
021-54880687
Fax
021-54880687
Country
China
ProdList
511
Advantage
55
Shanghai Carlow Chemicals Co., Ltd.
Tel
21-33526724 18930996265
Fax
37023730
Email
info@carlowchem.com
Country
China
ProdList
1922
Advantage
58
Taizhou Tongxin Bio-Tech Co., Ltd
Tel
0523-86818997 18652728585
Email
sales@allyrise.com
Country
China
ProdList
2965
Advantage
60
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
ShangHai AmK Pharmaceutical Technology Co., Ltd.
Tel
微信 17321281695 18019252918
Fax
17321281695
Email
sale@amkchem.com
Country
China
ProdList
15136
Advantage
55
Tianjin Anhao Biological Technology Co., Ltd.
Tel
Email
sales@ahpharmatech.com
Country
China
ProdList
5734
Advantage
55
Shanghai Tombiopharma Chemical Co. Ltd.
Tel
13391076197
Email
tombiopharma@163.com
Country
China
ProdList
4987
Advantage
55
Cool Pharm, Ltd
Tel
021-60455363 18019463053
Fax
50966098
Email
sales@coolpharm.com
Country
China
ProdList
12346
Advantage
58
Shanghai Mayzem Pharmtech Co., Ltd.
Tel
18501708306; 18501708306
Fax
021-68362870
Email
sales@mayzem.com
Country
China
ProdList
518
Advantage
56
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
NovoChemy Ltd.
Tel
86-(0)21-31261262 373522135
Fax
86-(0)21-33250524
Email
sales@novochemy.com
Country
China
ProdList
6498
Advantage
58
ShangHai Wisacheam Pharmaceutical Co., Ltd.
Tel
13817485796
Fax
QQ:895624079
Email
tim@wisacheampharm.com
Country
China
ProdList
3593
Advantage
58
JW & Y Pharmlab Co., Ltd.
Tel
021-64340559 13651849907;
Fax
021- 64345308
Email
xinyu_shi@jwypharmlab.com.cn
Country
China
ProdList
12000
Advantage
58
Shanghai Kahn Pharmaceutical Co., Ltd.
Tel
021-34979681; 17701870669
Fax
021-34979681
Email
41513101@qq.com
Country
China
ProdList
1785
Advantage
55
Zhengzhou Alfachem Co., Ltd.
Tel
0371-53765687 18937137882
Fax
QQ:2885373884
Email
2853979813@qq.com
Country
China
ProdList
7991
Advantage
55
Beatrice medicine technology Co., Ltd.
Tel
15769589321 1548536191
Email
beatricechem@aliyun.com
Country
China
ProdList
460
Advantage
50
Tcichem, Inc.
Tel
13918644899
Fax
-
Email
tianchong009@hotmail.com
Country
China
ProdList
1818
Advantage
55
Hubei Chuangliankangcheng Pharmaceutical Co., Ltd.
Tel
027-65388397 18164111589
Fax
027-65388397
Email
3321478047@qq.com
Country
China
ProdList
2007
Advantage
55
Chengdu DingDang Pharmaceutical Co., Ltd.
Tel
028-86040038 13980902949;
Fax
028-85149890
Email
market@dingdangchem.com
Country
China
ProdList
1853
Advantage
55
ShangHai Siyan Biological Technology Co., Ltd.
Tel
021-50908862，442785678，326799392 18721037013
Fax
021-50908862
Email
siyansales@126.com
Country
China
ProdList
9627
Advantage
58
Shanghai Haozhixiang Biotechnology Co., Ltd
Tel
526763801 13301653310
Fax
+86-21-51619052
Email
526763801@qq.com
Country
China
ProdList
9287
Advantage
55
Henan CoreyChem Co., Ltd
Tel
0371-86658258
Fax
0371-60996044
Email
info@coreychem.com
Country
China
ProdList
10453
Advantage
58
Shanghai Qiao Chemical Science Co., Ltd
Tel
021-58892003
Email
info@qiaochem.com
Country
China
ProdList
6059
Advantage
65
Shanghai Qing Cang Chemical Technology Co., Ltd.
Tel
00000000000
Fax
-
Email
sales@qingcangchem.com
Country
China
ProdList
509
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shanghai Changyan Chem & Tech Co., Ltd.
Tel
021-20242659 18930833303
Fax
+86 (21) 2024-2659
Email
Sales@changyanchem.cn
Country
China
ProdList
5001
Advantage
55
Changzhou Hopschain Chemical Co.,Ltd.
Tel
0519-85528066 13775048983
Fax
0519-85528066
Email
sales@hopschem.com
Country
China
ProdList
31553
Advantage
55
Shandong Xiya Chemical Co., Ltd.
Tel
4009903999 13395398332
Fax
0539-6365991
Email
sales@xiyashiji.com
Country
China
ProdList
20794
Advantage
60
Radiant Pharma & Tech. Co., Ltd
Tel
T:15050866711
Fax
QQ:2677337387
Email
wanglin.chen@radiant-pharma.com
Country
China
ProdList
466
Advantage
60
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Shanghai Huaxing Biological Technology Co., Ltd.
Tel
18621295758
Fax
-QQ:1449085402
Email
1449085402@qq.com
Country
China
ProdList
1951
Advantage
55
Shanghai Kangman Biological Technology Co., Ltd.
Tel
18800375331
Fax
021-50908862
Email
kangmansales@163.com
Country
China
ProdList
7570
Advantage
55
Shandong Ono Chemical Co., Ltd.
Tel
0539-6362799 20）
Fax
0539-6362799（To 20）
Country
China
ProdList
10007
Advantage
58
Huaian Hyperion pharmaceutical R&D Co.,Ltd.
Tel
18114966287
Fax
-
Email
sales@hyperionpharm.com
Country
China
ProdList
449
Advantage
58
Wuhan Sun-shine Bio-technology Corporation Limited
Tel
+86-027-6552-2453
Email
sales@sun-shinechem.com
Country
China
ProdList
727
Advantage
58
More
Less

View Lastest Price from 7-BROMO-1-HYDROXYISOQUINOLINE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
7-BROMO-1-HYDROXYISOQUINOLINE 223671-15-6
Price
US $10.00/KG
Min. Order
100KG
Purity
99%
Supply Ability
100 mt
Release date
2025-03-10
Career Henan Chemical Co
Product
7-BROMO-1-HYDROXYISOQUINOLINE 223671-15-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2019-12-31

223671-15-6, 7-BROMO-1-HYDROXYISOQUINOLINERelated Search:

7-BROMO-1-METHOXYISOQUINOLINE 7-BROMO-ISOQUINOLIN-1-YLAMINE 7-BROMO-1-CHLOROISOQUINOLINE 7-BROMO-1-METHYL-1H-INDAZOLE METHYL 7-BROMO-1-BENZOTHIOPHENE-2-CARBOXYLATE 6-BROMO-3-HYDROXYISOQUINOLINE 7-BROMO-2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONE 4-BROMO-1-HYDROXYISOQUINOLINE Isocarbostyril 7-BROMO-1-HYDROXYISOQUINOLINE 7-Bromoisoquinoline

  • 7-BROMO-1-HYDROXYISOQUINOLINE
  • 7-Bromoisocarbostyril
  • 7-BROMO-1-HYDROXYISOQUINOLINE, 98+%
  • 7-bromoisoquinolin-1-ol
  • 7-BroMoisoquinolin-1-one
  • 7-Bromo-1(2H)-isoquinolinone
  • 7-broMoisoquinolin-1(2H)-one
  • 7-Bromoisoquinolin-1-ol, 7-Bromo-1-hydroxy-2-azanaphthalene
  • 7-BroMo-1-hydroxyisoquinoline, 98+%, 98+%
  • 7-Bromoiso
  • 7-bromo-1-hydroxyisoquinoline 95%
  • 7-bromo-1,2-dihydroisoquinolin-1-one
  • 1(2H)-Isoquinolinone, 7-bromo-
  • 7-Bromo-1-hydroxyisoquinoL
  • 223671-15-6
  • Building Blocks
  • Chemical Synthesis
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Isoquinolines
  • in stock