5-Bromoisoquinoline
- Product Name
- 5-Bromoisoquinoline
- CAS No.
- 34784-04-8
- Chemical Name
- 5-Bromoisoquinoline
- Synonyms
- 5-BromoisoquinoL;AKOS BBS-00003132;BUTTPARK 44\07-76;5-BROMOISOQUINOLINE;5-Bromo Isoquinolin;Isoquinoline, 5-bromo-;5-Bromoisoquinoline,97%;5-Bromoisoquinoline,98%;5-Bromoisoquinoline >5-Bromoisoquinoline, HCl
- CBNumber
- CB3135741
- Molecular Formula
- C9H6BrN
- Formula Weight
- 208.05
- MOL File
- 34784-04-8.mol
5-Bromoisoquinoline Property
- Melting point:
- 83-87 °C (lit.)
- Boiling point:
- 95-97°C 0,1mm
- Density
- 1.564±0.06 g/cm3(Predicted)
- Flash point:
- 95-97°C/0.1mm
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform, Dichloromethane, Ethyl Acetate, Methanol
- form
- Solid
- pka
- 4.39±0.13(Predicted)
- color
- Yellow
- BRN
- 114468
- InChI
- InChI=1S/C9H6BrN/c10-9-3-1-2-7-6-11-5-4-8(7)9/h1-6H
- InChIKey
- CYJZJGYYTFQQBY-UHFFFAOYSA-N
- SMILES
- C1C2=C(C(Br)=CC=C2)C=CN=1
- CAS DataBase Reference
- 34784-04-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-21/22-20/21/22
- Safety Statements
- 26-36-36/37/39
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 29334900
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 594261
- Product name
- 5-Bromoisoquinoline
- Purity
- 98%
- Packaging
- 1g
- Price
- $25
- Updated
- 2023/01/07
- Product number
- 594261
- Product name
- 5-Bromoisoquinoline
- Purity
- 98%
- Packaging
- 5g
- Price
- $29
- Updated
- 2023/01/07
- Product number
- B3313
- Product name
- 5-Bromoisoquinoline
- Purity
- >96.0%(GC)(T)
- Packaging
- 1g
- Price
- $34
- Updated
- 2025/07/31
- Product number
- B3313
- Product name
- 5-Bromoisoquinoline
- Purity
- >96.0%(GC)(T)
- Packaging
- 5g
- Price
- $100
- Updated
- 2025/07/31
- Product number
- 10007079
- Product name
- 5-Bromoisoquinoline
- Purity
- ≥99%
- Packaging
- 500mg
- Price
- $29
- Updated
- 2024/03/01
5-Bromoisoquinoline Chemical Properties,Usage,Production
Description
5-
Chemical Properties
White to yellow-brown crystals
Uses
Starting material employed in palladium-catalyzed aminomethylation and amination reactions.
Synthesis Reference(s)
[1] W. Brown, A. Gouliaev. “Bromination of Isoquinoline, Quinoline, Quinazoline and Quinoxaline in Strong Acid.” ChemInform 98 1 (2002).
Synthesis
To mechanically stirred concd H2SO4 (42.5 mL) at 0 °C, isoquinoline (1; 5 mL, 42.5 mmol) was slowly added. The mixture was cooled to –25 °C, and NBS (9.83 g, 55.2 mmol) was added at such a rate that the reaction temperature was kept between –25 °C and –22 °C. The mixture was stirred at -22±1 °C for 2 h and at -18±1 °C for 3h. The mixture was then worked up as described above to give 6.16 g (72%) as a slightly off-white solid after chromatography; mp 81–82 °C. The solid was further purified by sublimation (75 °C/0.2 mmHg) to give 5-Bromoisoquinoline as a white powder[1].
References
[1] Patent: US2008/318941, 2008, A1. Location in patent: Page/Page column 22
[2] Patent: WO2009/23844, 2009, A2. Location in patent: Page/Page column 105-106
[3] Patent: US2008/200471, 2008, A1. Location in patent: Page/Page column 45; 45-46
[4] Patent: US2010/16297, 2010, A1. Location in patent: Page/Page column 25
[5] Patent: WO2010/21797, 2010, A1. Location in patent: Page/Page column 68
5-Bromoisoquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Bromoisoquinoline manufacturers
- Product
- 5-Bromoisoquinoline 34784-04-8
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2021-10-13
- Product
- 5-Bromoisoquinoline 34784-04-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-04
- Product
- 5-Bromoisoquinoline 34784-04-8
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2018-12-17