5-Bromo-8-nitroisoquinoline
Uses- Product Name
- 5-Bromo-8-nitroisoquinoline
- CAS No.
- 63927-23-1
- Chemical Name
- 5-Bromo-8-nitroisoquinoline
- Synonyms
- 5-BROMO-8-NITROISOQUINOLINE;5-BroMo-8-nitroisoquinolilne;Isoquinoline, 5-bromo-8-nitro-;5-Bromo-8-nitroisoquinoline >5-Bromo-8-nitroisoquinoline 90%;5-Bromo-8-nitroisoquinoline ISO 9001：2015 REACH
- CBNumber
- CB1779655
- Molecular Formula
- C9H5BrN2O2
- Formula Weight
- 253.05
- MOL File
- 63927-23-1.mol
5-Bromo-8-nitroisoquinoline Property
- Melting point:
- 136-140 °C
- Boiling point:
- 386.9±27.0 °C(Predicted)
- Density
- 1.747±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 2?+-.0.36(Predicted)
- color
- Light yellow to Yellow to Orange
- InChIKey
- ULGOLOXWHJEZNZ-UHFFFAOYSA-N
- CAS DataBase Reference
- 63927-23-1(CAS DataBase Reference)
Safety
- Hazard Codes
- T
- Risk Statements
- 25-37/38-41
- Safety Statements
- 26-39-45
- RIDADR
- UN 2811
- WGK Germany
- 3
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 675148
- Product name
- 5-Bromo-8-nitroisoquinoline
- Purity
- 90%
- Packaging
- 1g
- Price
- $51.9
- Updated
- 2023/01/07
- Product number
- B4163
- Product name
- 5-Bromo-8-nitroisoquinoline
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $73
- Updated
- 2025/07/31
- Product number
- B686288
- Product name
- 5-Bromo-8-nitroisoquinoline
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- B686288
- Product name
- 5-Bromo-8-nitroisoquinoline
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FB42318
- Product name
- 5-Bromo-8-nitroisoquinoline
- Packaging
- 5G
- Price
- $40
- Updated
- 2021/12/16
5-Bromo-8-nitroisoquinoline Chemical Properties,Usage,Production
Uses
5-Bromo-8-nitroisoquinoline is mainly used as an intermediate in organic synthesis and pharmaceutical chemistry, and can be used in the synthesis of drug molecules, pesticides, and dyes. In organic synthesis transformations, the bromine atom in 5-bromo-8-nitroisoquinoline can undergo debromination and hydrochemical oxidation under palladium and hydrogen conditions; in addition, the nitrogen atom on the isoquinoline ring can be oxidized to nitrogen oxides under the action of appropriate oxidizing agents.
Chemical Properties
It is light yellow solid powder under normal temperature and pressure, with certain alkalinity, can form salt with various acids.
Synthesis
34784-04-8
63927-23-1
Example 2: An aqueous solution of potassium nitrate (1.78 g, 8.56 mmol) was slowly added dropwise to a solution of 5-bromoisoquinoline dissolved in 12 mL of concentrated sulfuric acid. The reaction mixture was stirred at room temperature for 3 hours before it was poured into ice water and neutralized with concentrated ammonium hydroxide solution. The resulting yellow precipitate was extracted by ethyl acetate (3 x 10 mL) and the combined organic layers were washed with saturated sodium chloride solution and dried over anhydrous magnesium sulfate. After filtration, the organic phase was concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to afford 5-bromo-8-nitroisoquinoline in 96% yield using a hexane solution of 40% ethyl acetate as eluent.
References
[1] Patent: WO2004/76424, 2004, A1. Location in patent: Page 174-175
[2] Patent: EP698025, 1997, B1
[3] Patent: US5917053, 1999, A
[4] Patent: US5436250, 1995, A
[5] Patent: EP633262, 1995, A1
5-Bromo-8-nitroisoquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Bromo-8-nitroisoquinoline manufacturers
- Product
- 5-Bromo-8-nitroisoquinoline 63927-23-1
- Price
- US $8.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10tons
- Release date
- 2018-12-25