ChemicalBook > CAS DataBase List > 5-Bromo-8-nitroisoquinoline

5-Bromo-8-nitroisoquinoline

Uses

Product Name: 5-Bromo-8-nitroisoquinoline
CAS No.: 63927-23-1
Chemical Name: 5-Bromo-8-nitroisoquinoline
Synonyms: 5-BROMO-8-NITROISOQUINOLINE;5-BroMo-8-nitroisoquinolilne;Isoquinoline, 5-bromo-8-nitro-;5-Bromo-8-nitroisoquinoline >5-Bromo-8-nitroisoquinoline 90%;5-Bromo-8-nitroisoquinoline ISO 9001：2015 REACH
CBNumber: CB1779655
Molecular Formula: C9H5BrN2O2
Formula Weight: 253.05
MOL File: 63927-23-1.mol

Less

5-Bromo-8-nitroisoquinoline Property

Melting point:: 136-140 °C
Boiling point:: 386.9±27.0 °C(Predicted)
Density: 1.747±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
pka: 2?+-.0.36(Predicted)
color: Light yellow to Yellow to Orange
InChIKey: ULGOLOXWHJEZNZ-UHFFFAOYSA-N
CAS DataBase Reference: 63927-23-1(CAS DataBase Reference)

Less

Safety

Hazard Codes: T
Risk Statements: 25-37/38-41
Safety Statements: 26-39-45
RIDADR: UN 2811
WGK Germany: 3
HS Code: 2933499090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 675148
Product name: 5-Bromo-8-nitroisoquinoline
Purity: 90%
Packaging: 1g
Price: $51.9
Updated: 2023/01/07

TCI Chemical

Product number: B4163
Product name: 5-Bromo-8-nitroisoquinoline
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $73
Updated: 2025/07/31

TRC

Product number: B686288
Product name: 5-Bromo-8-nitroisoquinoline
Packaging: 500mg
Price: $65
Updated: 2021/12/16

TRC

Product number: B686288
Product name: 5-Bromo-8-nitroisoquinoline
Packaging: 100mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB42318
Product name: 5-Bromo-8-nitroisoquinoline
Packaging: 5G
Price: $40
Updated: 2021/12/16

Less

5-Bromo-8-nitroisoquinoline Chemical Properties,Usage,Production

Uses

5-Bromo-8-nitroisoquinoline is mainly used as an intermediate in organic synthesis and pharmaceutical chemistry, and can be used in the synthesis of drug molecules, pesticides, and dyes. In organic synthesis transformations, the bromine atom in 5-bromo-8-nitroisoquinoline can undergo debromination and hydrochemical oxidation under palladium and hydrogen conditions; in addition, the nitrogen atom on the isoquinoline ring can be oxidized to nitrogen oxides under the action of appropriate oxidizing agents.

Chemical Properties

It is light yellow solid powder under normal temperature and pressure, with certain alkalinity, can form salt with various acids.

Synthesis

34784-04-8

63927-23-1

Example 2: An aqueous solution of potassium nitrate (1.78 g, 8.56 mmol) was slowly added dropwise to a solution of 5-bromoisoquinoline dissolved in 12 mL of concentrated sulfuric acid. The reaction mixture was stirred at room temperature for 3 hours before it was poured into ice water and neutralized with concentrated ammonium hydroxide solution. The resulting yellow precipitate was extracted by ethyl acetate (3 x 10 mL) and the combined organic layers were washed with saturated sodium chloride solution and dried over anhydrous magnesium sulfate. After filtration, the organic phase was concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to afford 5-bromo-8-nitroisoquinoline in 96% yield using a hexane solution of 40% ethyl acetate as eluent.

References

[1] Patent: WO2004/76424, 2004, A1. Location in patent: Page 174-175
[2] Patent: EP698025, 1997, B1
[3] Patent: US5917053, 1999, A
[4] Patent: US5436250, 1995, A
[5] Patent: EP633262, 1995, A1

5-Bromo-8-nitroisoquinoline Preparation Products And Raw materials

Raw materials

Preparation Products

Less

5-Bromo-8-nitroisoquinoline Suppliers

Americas 1 China 173 Europe 1 Germany 2 India 9 Japan 1 Switzerland 1 The Netherlands 1 Ukraine 2 United Kingdom 6 United States 33 Global 230

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Tetranov Biopharm

Tel: 13526569071
Email: sales@leadmedpharm.com
Country: China
ProdList: 7892
Advantage: 64

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9883
Advantage: 59

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Shanghai Ennopharm Co., Ltd.

Tel: +86 (21) 6435-5022
Country: China
ProdList: 4267
Advantage: 65

Shanghai Sphchem Co., Ltd.

Tel: 021-56491756 13512199871
Fax: 021-5649-1756
Email: 2819742715@qq.com
Country: China
ProdList: 4000
Advantage: 55

Chengdu Forest Science and Technology Development Co., Ltd.

Tel: 18030648795
Fax: 028-61777050
Email: sales@cdforestchem.com
Country: China
ProdList: 2000
Advantage: 58

Shanghai Litong Chemical Technology Co.,Ltd.

Tel: 13598610367 0373-7129549
Fax: 0373-8369699
Email: 2468833170@qq.com
Country: China
ProdList: 932
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19913
Advantage: 55

Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 150-2103-5486 18017383231
Fax: qq：2817624287
Email: 983544897@qq.com
Country: China
ProdList: 9342
Advantage: 55

Shanghai potentpharm CO.,Ltd

Tel: 13524892556
Fax: (86) 21 51969655， QQ： 263541193
Email: sales-cn@potentpharm.com
Country: China
ProdList: 1011
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22514
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Shanghai Sheepchem Co., Ltd.

Tel: +86 (21) 6715-7650
Fax: +86 (21) 6715-7651
Email: sheepchem@163.com
Country: China
ProdList: 994
Advantage: 60

Runpharm Technology Limited

Tel: 18171398856 2968382473
Fax: 0086-21-50758330
Email: service@runpharm.com
Country: China
ProdList: 716
Advantage: 55

Wuhan Kaymke Chemical Co., Ltd.,

Tel: 027-027-87342388 18086026008
Fax: 027-87342388
Email: sales@kaymke.com
Country: China
ProdList: 3731
Advantage: 55

Shanghai Witofly Chemical Co.,Ltd

Tel
Email: sales@witofly.com
Country: China
ProdList: 2864
Advantage: 52

Shanghai Yolne Chemical Co., Ltd.

Tel: 021-62960152
Fax: 021-52212593
Email: 934678158@qq.com
Country: China
ProdList: 9899
Advantage: 55

Shanghai Raise Chemical Technology Co.,Ltd

Tel: +86-021-50935922
Fax: +86-021-33847795
Country: China
ProdList: 7865
Advantage: 55

Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.

Tel: +86-28-85122536 85324413
Fax: +86-28-85326443
Email: market@astatech.cn
Country: China
ProdList: 8026
Advantage: 55

Yancheng Orgunion Pharmaceutical Sci & Tech Co., Ltd.

Tel: 0515-89701588 13770166955
Fax: 0515-87400189
Email: orgunion@orgunion.com
Country: China
ProdList: 620
Advantage: 55

CEG Chemical Science&Technology Co., Ltd.

Tel: Mobile:13665161512
Fax: +86-510-68873513
Country: China
ProdList: 1785
Advantage: 58

Amatek Scientific Co. Ltd.

Tel: 0512-56316828 4008675858
Fax: +86-512-56316826
Email: sales@amateksci.com
Country: China
ProdList: 9874
Advantage: 55

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9979
Advantage: 55

Nanjing Credit Trading Co.,Ltd

Tel: 025-52164950
Fax: 025-86800069
Email: Googlexu_0114@sina.com
Country: China
ProdList: 644
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Sense Chemicals (Shanghai) Co., Ltd.

Tel: +86 13590492756
Fax: +86 (0)21 57626234
Email: michael.he@sensechemicals.com
Country: China
ProdList: 426
Advantage: 58

Shanghai Worldyang Chemical Co.,Ltd.

Tel: 021-021-56795766
Fax: +86-21-56795266
Email: sales@worldyachem.com
Country: China
ProdList: 9476
Advantage: 58

Chengdu HuaXia Chemical Reagent Co. Ltd

Tel: 400-1166-196 13458535857
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 13350
Advantage: 58

Jiaxing Novartis Chemical Co., Ltd.

Tel: 18957373295
Fax: -
Country: China
ProdList: 1580
Advantage: 58

Shanghai HuanChuan Industry Co.,Ltd.

Tel: 021-61478794
Fax: 021-61478794
Email: sales@hcshhai.com
Country: China
ProdList: 9793
Advantage: 50

Shanghai Na Qian Chemical Technology Co. Ltd.

Tel: 13598610367
Fax: QQ:2468833170
Email: 2841375912@qq.com
Country: China
ProdList: 2789
Advantage: 52

Credit Asia Chemical Co., Ltd.

Tel: +86 (21) 61124340
Fax: +86 (21) 6129-4103
Country: China
ProdList: 9756
Advantage: 58

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Shanghai YuanQi Biotechnology Co., Ltd.

Tel: +86-2332782371 +86-18120098618
Email: sales@adobechem.com
Country: China
ProdList: 1250
Advantage: 50

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Zhengzhou Guancheng Laboratory equipment Sales

Tel: 0371-88888888 272369594
Fax: QQ:272369594
Email: 2723695949@qq.com
Country: China
ProdList: 4956
Advantage: 50

Shanghai Boyners Pharm-Tech Co., Ltd.

Tel: 13817873692
Fax: 021-31329586
Email: mkt@boynerspharm.com
Country: China
ProdList: 1707
Advantage: 55

JW & Y Pharmlab Co., Ltd.

Tel: 021-64340559 13651849907;
Fax: 021- 64345308
Email: xinyu_shi@jwypharmlab.com.cn
Country: China
ProdList: 12000
Advantage: 58

Shanghai Kahn Pharmaceutical Co., Ltd.

Tel: 021-34979681; 17701870669
Fax: 021-34979681
Email: 41513101@qq.com
Country: China
ProdList: 1785
Advantage: 55

Zhengzhou Alfachem Co., Ltd.

Tel: 0371-53765687 18937137882
Fax: QQ:2885373884
Email: 2853979813@qq.com
Country: China
ProdList: 7991
Advantage: 55

Wuhan Chemwish Technology Co.， Ltd

Tel: 027-67849912
Fax: 027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 9148
Advantage: 60

Less

View Lastest Price from 5-Bromo-8-nitroisoquinoline manufacturers

Career Henan Chemical Co

Product: 5-Bromo-8-nitroisoquinoline 63927-23-1
Price: US $8.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10tons
Release date: 2018-12-25

63927-23-1, 5-Bromo-8-nitroisoquinolineRelated Search:

3-Methylisoquinoline 1-METHYLISOQUINOLINE 5-Bromoisoquinoline 4-Nitrobenzoic acid Isoquinoline 2,4,6-Trinitrotoluene 3-Bromonitrobenzene 4-Nitrophenol Nitromethane Nitrobenzene Bromine 5-BROMO-8-ISOQUINOLINEAMINE 8-Aminoisoquinoline 8-BROMO-5-NITRO-ISOQUINOLINE 1-bromo-4-nitroisoquinoline 4-BROMO-5-NITROISOQUINOLINE 5-Bromo-8-nitroisoquinoline 5-BROMO-8-NITROISOQUINOLINE, 95+%

5-BROMO-8-NITROISOQUINOLINE

Isoquinoline, 5-bromo-8-nitro-

5-BroMo-8-nitroisoquinolilne

5-Bromo-8-nitroisoquinoline 90%

5-Bromo-8-nitroisoquinoline &gt

5-Bromo-8-nitroisoquinoline ISO 9001：2015 REACH

63927-23-1

Halides

Heterocycles

Halogenated Heterocycles

Heterocyclic Building Blocks

Isoquinolines

IsoquinolinesBuilding Blocks