8-Aminoisoquinoline
- Product Name
- 8-Aminoisoquinoline
- CAS No.
- 23687-27-6
- Chemical Name
- 8-Aminoisoquinoline
- Synonyms
- 8-AminoisoquinoL;8-Isoquinolinamine;ISOQUINOLIN-8-AMINE;8-AMINOISOQUINOLINE;8-amine-isoquinoline;ISOQUINOLIN-8-YLAMINE;8-Aminoisoquinoline95%;8-Aminoisoquinoline 98%;8-Aminoisoquinoline ,98%;8-Aminoisoquinoline, 97%, HC-6001
- CBNumber
- CB0759102
- Molecular Formula
- C9H8N2
- Formula Weight
- 144.17
- MOL File
- 23687-27-6.mol
8-Aminoisoquinoline Property
- Melting point:
- 155-157
- Boiling point:
- 335.7±17.0 °C(Predicted)
- Density
- 1.210±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- form
- Crystalline Powder
- pka
- 6.20±0.23(Predicted)
- color
- Brown
- InChI
- InChI=1S/C9H8N2/c10-9-3-1-2-7-4-5-11-6-8(7)9/h1-6H,10H2
- InChIKey
- GUSYANXQYUJOBH-UHFFFAOYSA-N
- SMILES
- C1C2=C(C=CC=C2N)C=CN=1
- CAS DataBase Reference
- 23687-27-6(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- A576723
- Product name
- 8-Aminoisoquinoline
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR3549
- Product name
- 8-Aminoisoquinoline
- Purity
- 98%
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 3H30-1-B2
- Product name
- 8-Aminoisoquinoline
- Purity
- 98.0%
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FA42094
- Product name
- 8-Aminoisoquinoline
- Packaging
- 1g
- Price
- $125
- Updated
- 2021/12/16
- Product number
- W4736
- Product name
- 8-Aminoisoquinoline
- Packaging
- 5g
- Price
- $171
- Updated
- 2021/12/16
8-Aminoisoquinoline Chemical Properties,Usage,Production
Chemical Properties
Brown solid
Uses
8-Aminoisoquinoline and its derivatives are used as intermediates for antimalarial drugs in the pharmaceutical field. For example, their structure is similar to the antimalarial drug primaquine.
Synthesis
63927-23-1
23687-27-6
General procedure for the synthesis of 8-aminoisoquinolines from 5-bromo-8-nitroisoquinolines: 5-bromo-8-nitroisoquinolines (1.00 g, 3.95 mmol) were dissolved in methanol (70 mL), and hydrogenation was carried out by adding palladium/activated charcoal (10% Pd, 200 mg) as a catalyst for 18 hr at room temperature and atmospheric pressure. Upon completion of the reaction, the reaction mixture was filtered through Celite to remove the catalyst. The filtrate was concentrated and purified by column chromatography (eluent: ethyl acetate/heptane) to afford the target compound 8-aminoisoquinoline (100 mg, 18% yield) as a greenish-brown solid.1H NMR (DMSO-d6, 400 MHz) δ 9.43 (s, 1H), 8.32 (d, 1H), 7.54 (d, 1H), 7.40 (dd, 1H) , 6.99 (d, 1H), 6.72 (d, 1H), 6.22 (s, 2H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 4, p. 803 - 806
[2] Journal of Medicinal Chemistry, 2005, vol. 48, # 3, p. 744 - 752
[3] Patent: WO2009/130481, 2009, A1. Location in patent: Page/Page column 143
[4] Journal of Medicinal Chemistry, 2005, vol. 48, # 15, p. 4972 - 4982
[5] Patent: WO2006/32851, 2006, A1. Location in patent: Page/Page column 49
8-Aminoisoquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 8-Aminoisoquinoline manufacturers
- Product
- 8-Aminoisoquinoline 23687-27-6
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 tons
- Release date
- 2024-11-27
- Product
- 8-Aminoisoquinoline 23687-27-6
- Price
- US $15.00/kg
- Min. Order
- 1kg
- Purity
- 99.99%
- Supply Ability
- 50000tons
- Release date
- 2023-08-03
- Product
- 8-Aminoisoquinoline 23687-27-6
- Price
- US $15.00/kg
- Min. Order
- 1kg
- Purity
- 99.99%
- Supply Ability
- 50000tons
- Release date
- 2023-08-18