ChemicalBook > CAS DataBase List > 8-Aminoisoquinoline

8-Aminoisoquinoline

Product Name: 8-Aminoisoquinoline
CAS No.: 23687-27-6
Chemical Name: 8-Aminoisoquinoline
Synonyms: 8-AminoisoquinoL;8-Isoquinolinamine;ISOQUINOLIN-8-AMINE;8-AMINOISOQUINOLINE;8-amine-isoquinoline;ISOQUINOLIN-8-YLAMINE;8-Aminoisoquinoline95%;8-Aminoisoquinoline 98%;8-Aminoisoquinoline ,98%;8-Aminoisoquinoline, 97%, HC-6001
CBNumber: CB0759102
Molecular Formula: C9H8N2
Formula Weight: 144.17
MOL File: 23687-27-6.mol

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8-Aminoisoquinoline Property

Melting point:: 155-157
Boiling point:: 335.7±17.0 °C(Predicted)
Density: 1.210±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
form: Crystalline Powder
pka: 6.20±0.23(Predicted)
color: Brown
InChI: InChI=1S/C9H8N2/c10-9-3-1-2-7-4-5-11-6-8(7)9/h1-6H,10H2
InChIKey: GUSYANXQYUJOBH-UHFFFAOYSA-N
SMILES: C1C2=C(C=CC=C2N)C=CN=1
CAS DataBase Reference: 23687-27-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 41
Safety Statements: 26-39
Hazard Note: Harmful/Irritant/Keep Cold
HS Code: 29334900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: A576723
Product name: 8-Aminoisoquinoline
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: OR3549
Product name: 8-Aminoisoquinoline
Purity: 98%
Packaging: 1g
Price: $50
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-1-B2
Product name: 8-Aminoisoquinoline
Purity: 98.0%
Packaging: 1g
Price: $55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA42094
Product name: 8-Aminoisoquinoline
Packaging: 1g
Price: $125
Updated: 2021/12/16

AK Scientific

Product number: W4736
Product name: 8-Aminoisoquinoline
Packaging: 5g
Price: $171
Updated: 2021/12/16

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8-Aminoisoquinoline Chemical Properties,Usage,Production

Chemical Properties

Brown solid

Uses

8-Aminoisoquinoline and its derivatives are used as intermediates for antimalarial drugs in the pharmaceutical field. For example, their structure is similar to the antimalarial drug primaquine.

Synthesis

63927-23-1

23687-27-6

General procedure for the synthesis of 8-aminoisoquinolines from 5-bromo-8-nitroisoquinolines: 5-bromo-8-nitroisoquinolines (1.00 g, 3.95 mmol) were dissolved in methanol (70 mL), and hydrogenation was carried out by adding palladium/activated charcoal (10% Pd, 200 mg) as a catalyst for 18 hr at room temperature and atmospheric pressure. Upon completion of the reaction, the reaction mixture was filtered through Celite to remove the catalyst. The filtrate was concentrated and purified by column chromatography (eluent: ethyl acetate/heptane) to afford the target compound 8-aminoisoquinoline (100 mg, 18% yield) as a greenish-brown solid.1H NMR (DMSO-d6, 400 MHz) δ 9.43 (s, 1H), 8.32 (d, 1H), 7.54 (d, 1H), 7.40 (dd, 1H) , 6.99 (d, 1H), 6.72 (d, 1H), 6.22 (s, 2H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 4, p. 803 - 806
[2] Journal of Medicinal Chemistry, 2005, vol. 48, # 3, p. 744 - 752
[3] Patent: WO2009/130481, 2009, A1. Location in patent: Page/Page column 143
[4] Journal of Medicinal Chemistry, 2005, vol. 48, # 15, p. 4972 - 4982
[5] Patent: WO2006/32851, 2006, A1. Location in patent: Page/Page column 49

8-Aminoisoquinoline Preparation Products And Raw materials

Raw materials

Heptane Isoquinoline Hexane Ammonium hydroxide N-Bromosuccinimide Palladium hydroxide Sodium sulfate Sodium chloride Triethylamine Diethyl ether Ethyl acetate Hydrogen Methanol Ammonium acetate Magnesium sulfate PETROLEUM ETHER Sulfuric acid Sodium carbonate Potassium nitrate

Preparation Products

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8-Aminoisoquinoline Suppliers

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View Lastest Price from 8-Aminoisoquinoline manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 8-Aminoisoquinoline 23687-27-6
Price: US $9.80/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 tons
Release date: 2024-11-27

Henan Bao Enluo International TradeCo.，LTD

Product: 8-Aminoisoquinoline 23687-27-6
Price: US $15.00/kg
Min. Order: 1kg
Purity: 99.99%
Supply Ability: 50000tons
Release date: 2023-08-03

Henan Bao Enluo International TradeCo.，LTD

Product: 8-Aminoisoquinoline 23687-27-6
Price: US $15.00/kg
Min. Order: 1kg
Purity: 99.99%
Supply Ability: 50000tons
Release date: 2023-08-18

23687-27-6, 8-AminoisoquinolineRelated Search:

Glucosamine EC 2.6.1.2 Aminopyrine Isoquinoline Sulfamic acid Acetaminophen Isoquinoline, 6-iodo- (9CI) 8-Iodoisoquinoline 8-Iodo quinoline pentaquine Primaquine diphosphate 2-METHYL-8-NITROQUINOLINE 2-[(2-amino-5-methylph2-[(2-amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n',n'-tetraacetic acid tetrapotassium saltenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n 8-Nitroquinoline 8-Aminoquinaldine 7-METHYL-8-NITROQUINOLINE 6-METHOXY-8-NITROQUINOLINE 1-AMINOISOQUINOLINE

8-AMINOISOQUINOLINE

ISOQUINOLIN-8-AMINE

ISOQUINOLIN-8-YLAMINE

8-Aminoisoquinoline95%

8-Aminoisoquinoline 98%

8-amine-isoquinoline

8-Isoquinolinamine

8-Aminoisoquinoline ,98%

Isoquinolin-8-amine, 8-Amino-2-azanaphthalene

8-AminoisoquinoL

8-Aminoisoquinoline ISO 9001：2015 REACH

8-Aminoisoquinoline, 97%, HC-6001

23687-27-6

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