5-BROMOINDOLINE
- Product Name
- 5-BROMOINDOLINE
- CAS No.
- 22190-33-6
- Chemical Name
- 5-BROMOINDOLINE
- Synonyms
- AKOS BC-0891;5-BROMOINDOLINE;5-Bromoindoline >5-Bromoindoline 97%;5-Bromoindoline,97%;5-bromodihydroindole;5-Bromoindoline,98+%;Zopiclone Impurity 34;5-BroMo-2,3-dihydroindole;5-BROMO-2,3-DIHYDRO-1H-INDOLE
- CBNumber
- CB5149584
- Molecular Formula
- C8H8BrN
- Formula Weight
- 198.06
- MOL File
- 22190-33-6.mol
5-BROMOINDOLINE Property
- Melting point:
- 36-40 °C (lit.)
- Boiling point:
- 114-115°C 5mm
- Density
- 1.5240 g/cm3
- refractive index
- 1.63
- Flash point:
- >230 °F
- storage temp.
- -20°C
- solubility
- DMSO, Methanol
- form
- Solid
- pka
- 4.35±0.20(Predicted)
- color
- Off-White
- BRN
- 121590
- InChI
- InChI=1S/C8H8BrN/c9-7-1-2-8-6(5-7)3-4-10-8/h1-2,5,10H,3-4H2
- InChIKey
- QEDCHCLHHGGYBT-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=C(Br)C=C2)CC1
- CAS DataBase Reference
- 22190-33-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- PackingGroup
- III
- HS Code
- 29339900
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 642371
- Product name
- 5-Bromoindoline
- Purity
- 97%
- Packaging
- 5g
- Price
- $90.1
- Updated
- 2025/07/31
- Product number
- 642371
- Product name
- 5-Bromoindoline
- Purity
- 97%
- Packaging
- 1g
- Price
- $51.6
- Updated
- 2023/01/07
- Product number
- B3885
- Product name
- 5-Bromoindoline
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $24
- Updated
- 2025/07/31
- Product number
- B3885
- Product name
- 5-Bromoindoline
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $70
- Updated
- 2025/07/31
- Product number
- B684610
- Product name
- 5-Bromoindoline
- Packaging
- 50g
- Price
- $990
- Updated
- 2021/12/16
5-BROMOINDOLINE Chemical Properties,Usage,Production
Chemical Properties
White to brown low melting solid
Uses
5-Bromoindoline is a brominated indoline derivative and a product of biocatalyzed halogenation of nucleobase analogs. 5-Bromoindoline is used in the synthetic preparation of biologically active compou nds such as selective human β3 adrenergic receptor agonists.
Synthesis
22190-38-1
22190-33-6
A) 38 g (0.16 mol) of 1-acetyl-5-bromoindoline, 31 g of concentrated hydrochloric acid and 41 g of ethanol were added to the reaction flask and stirred thoroughly to obtain reaction mixture I; B) reaction mixture I was reacted at 78 °C for 4 h. Complete disappearance of the raw materials was confirmed by chromatographic monitoring; C) the reaction mixture was neutralized using 55 g of sodium hydroxide solution; D) the organic phase J and the aqueous phase K were separated; E) the organic phase J was extracted three times using 445 g of chloroform. K; E) Organic phase J was extracted three times with 445 g of chloroform. The organic layers were combined and the solvent was recovered to give 30.74 g of 5-bromodihydroindole in 98.04% yield and ≥99% purity.
References
[1] Patent: CN106432040, 2017, A. Location in patent: Paragraph 0108-0113; 0135-0140; 0162-0167
[2] European Journal of Medicinal Chemistry, 2006, vol. 41, # 1, p. 88 - 100
[3] Tetrahedron Letters, 2004, vol. 45, # 25, p. 4827 - 4830
[4] Patent: CN106966950, 2017, A. Location in patent: Paragraph 0022
[5] Patent: US2011/98311, 2011, A1
5-BROMOINDOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-BROMOINDOLINE manufacturers
- Product
- 5-BROMOINDOLINE 22190-33-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 5-BROMOINDOLINE 22190-33-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- 5-Bromoindoline 5-Bromo-2,3-dihydro-1H-indole in stock Factory 22190-33-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- TOP 3 Factory in China
- Supply Ability
- Top 3 production capacity Factory
- Release date
- 2019-04-03