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5-BROMOINDOLINE

Product Name
5-BROMOINDOLINE
CAS No.
22190-33-6
Chemical Name
5-BROMOINDOLINE
Synonyms
AKOS BC-0891;5-BROMOINDOLINE;5-Bromoindoline >5-Bromoindoline 97%;5-Bromoindoline,97%;5-bromodihydroindole;5-Bromoindoline,98+%;Zopiclone Impurity 34;5-BroMo-2,3-dihydroindole;5-BROMO-2,3-DIHYDRO-1H-INDOLE
CBNumber
CB5149584
Molecular Formula
C8H8BrN
Formula Weight
198.06
MOL File
22190-33-6.mol
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5-BROMOINDOLINE Property

Melting point:
36-40 °C (lit.)
Boiling point:
114-115°C 5mm
Density 
1.5240 g/cm3
refractive index 
1.63
Flash point:
>230 °F
storage temp. 
-20°C
solubility 
DMSO, Methanol
form 
Solid
pka
4.35±0.20(Predicted)
color 
Off-White
BRN 
121590
InChI
InChI=1S/C8H8BrN/c9-7-1-2-8-6(5-7)3-4-10-8/h1-2,5,10H,3-4H2
InChIKey
QEDCHCLHHGGYBT-UHFFFAOYSA-N
SMILES
N1C2=C(C=C(Br)C=C2)CC1
CAS DataBase Reference
22190-33-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
PackingGroup 
III
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
642371
Product name
5-Bromoindoline
Purity
97%
Packaging
5g
Price
$90.1
Updated
2025/07/31
Sigma-Aldrich
Product number
642371
Product name
5-Bromoindoline
Purity
97%
Packaging
1g
Price
$51.6
Updated
2023/01/07
TCI Chemical
Product number
B3885
Product name
5-Bromoindoline
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$24
Updated
2025/07/31
TCI Chemical
Product number
B3885
Product name
5-Bromoindoline
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$70
Updated
2025/07/31
TRC
Product number
B684610
Product name
5-Bromoindoline
Packaging
50g
Price
$990
Updated
2021/12/16
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5-BROMOINDOLINE Chemical Properties,Usage,Production

Chemical Properties

White to brown low melting solid

Uses

5-Bromoindoline is a brominated indoline derivative and a product of biocatalyzed halogenation of nucleobase analogs. 5-Bromoindoline is used in the synthetic preparation of biologically active compou nds such as selective human β3 adrenergic receptor agonists.

Synthesis

22190-38-1

22190-33-6

A) 38 g (0.16 mol) of 1-acetyl-5-bromoindoline, 31 g of concentrated hydrochloric acid and 41 g of ethanol were added to the reaction flask and stirred thoroughly to obtain reaction mixture I; B) reaction mixture I was reacted at 78 °C for 4 h. Complete disappearance of the raw materials was confirmed by chromatographic monitoring; C) the reaction mixture was neutralized using 55 g of sodium hydroxide solution; D) the organic phase J and the aqueous phase K were separated; E) the organic phase J was extracted three times using 445 g of chloroform. K; E) Organic phase J was extracted three times with 445 g of chloroform. The organic layers were combined and the solvent was recovered to give 30.74 g of 5-bromodihydroindole in 98.04% yield and ≥99% purity.

References

[1] Patent: CN106432040, 2017, A. Location in patent: Paragraph 0108-0113; 0135-0140; 0162-0167
[2] European Journal of Medicinal Chemistry, 2006, vol. 41, # 1, p. 88 - 100
[3] Tetrahedron Letters, 2004, vol. 45, # 25, p. 4827 - 4830
[4] Patent: CN106966950, 2017, A. Location in patent: Paragraph 0022
[5] Patent: US2011/98311, 2011, A1

5-BROMOINDOLINE Preparation Products And Raw materials

Raw materials

Acetic anhydride Cyclohexane Acetyl chloride Sodium Triethylamine Indoline Sodium bisulfite Tetrahydrofuran Ethyl acetate Hydrochloric acid Bromine Dichloromethane Acetic acid Methanol Sodium hydroxide Magnesium sulfate

Preparation Products

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5-BROMOINDOLINE Suppliers

Americas 1 Canada 1 China 211 Europe 3 Germany 5 India 20 Japan 1 Switzerland 1 Ukraine 2 United Kingdom 14 United States 30 Global 289
OTAVA chemicals
Tel
--
Fax
--
Email
north.america@otavachemicals.com
Country
Ukraine
ProdList
6495
Advantage
72
UkrOrgSynthesis Ltd.
Tel
--
Fax
--
Email
y.barysheva@ukrorgsynth.com
Country
Ukraine
ProdList
6230
Advantage
38
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View Lastest Price from 5-BROMOINDOLINE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
5-BROMOINDOLINE 22190-33-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
5-BROMOINDOLINE 22190-33-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Chemwill Asia Co.,Ltd.
Product
5-Bromoindoline 5-Bromo-2,3-dihydro-1H-indole in stock Factory 22190-33-6
Price
US $1.00/KG
Min. Order
1KG
Purity
TOP 3 Factory in China
Supply Ability
Top 3 production capacity Factory
Release date
2019-04-03

22190-33-6, 5-BROMOINDOLINERelated Search:

5-Bromoisoquinoline 5-BroMo-2,3-dihydro-1H-indolehydrochloride 5-Bromo-2-oxindole 5-Bromoindazole 5-BROMOINDOLE-3-ACETIC ACID 5-Bromoindole-3-acetonitrile 5-Bromoindole-3-carboxaldehyde 1-Piperazinecarboxylicacid,4-methyl-,ethylester(6CI,9CI) 8-METHYLXANTHINE N-(5-Chloro-2-pyridinyl)-2-pyrazinecarboxaMide (Zopiclone IMpurity) Benzyl (3S,4R)-3-ethyl-4-(3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)pyrrolidine-1-carboxylate N-(5-Chloro-2-pyridinyl)-3-(hydroxyMethyl)-2-pyrazinecarboxaMide 8-PHENYLTHEOPHYLLINE 3-(5-CHLOROPYRID-2-YL)CARBAMOYLPYRAZINE-2-CARBOXYLIC ACID(WXG01564) Substituted pyrazine 2-Acetamido-5-chloropyridine CHEMBRDG-BB 7613529 6-(5-Chloro-2-pyridyl)-5H-pyrrolo[3,4-b]pyrazine-5,7(6H)-dione

  • 5-BROMOINDOLINE
  • AKOS BC-0891
  • 5-BROMO-2,3-DIHYDRO-1H-INDOLE
  • 5-Bromoindoline,98+%
  • 5-Bromoindoline,97%
  • 5-bromodihydroindole
  • 1H-Indole, 5-broMo-2,3-dihydro-
  • 5-BroMo-2,3-dihydroindole
  • 5-Bromoindoline 5-Bromo-2,3-dihydro-1H-indole in stock Factory
  • 5-Bromoindoline 97%
  • 5-Bromoindoline &gt
  • Zopiclone Impurity 34
  • 22190-33-6
  • 22190-33-67
  • C8H8BrN
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Indolines
  • Building Blocks
  • Heterocycle-Indole series
  • Indoles and derivatives
  • Indoline & Oxindole
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Indolines
  • IndolinesBuilding Blocks