1,3-DIBROMOISOQUINOLINE
- Product Name
- 1,3-DIBROMOISOQUINOLINE
- CAS No.
- 53987-60-3
- Chemical Name
- 1,3-DIBROMOISOQUINOLINE
- Synonyms
- 1,3-Dibromoisoquineline;1,3-DIBROMOISOQUINOLINE;Isoquinoline, 1,3-dibromo-;1,3-Dibromoisoquinoline 98%;1,3-DIBROMOISOQUINOLINE ISO 9001：2015 REACH
- CBNumber
- CB9444100
- Molecular Formula
- C9H5Br2N
- Formula Weight
- 286.95
- MOL File
- 53987-60-3.mol
1,3-DIBROMOISOQUINOLINE Property
- Boiling point:
- 370.9±22.0 °C(Predicted)
- Density
- 1.923±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -1.49±0.50(Predicted)
- Appearance
- White to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D425513
- Product name
- 1,3-Dibromoisoquinoline
- Packaging
- 1g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 411035
- Product name
- 1,3-Dibromoisoquinoline
- Packaging
- 100mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- 072423
- Product name
- 1,3-Dibromoisoquinoline
- Purity
- 95+%
- Packaging
- 500mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- FD42237
- Product name
- 1,3-Dibromoisoquinoline
- Packaging
- 250mg
- Price
- $187.5
- Updated
- 2021/12/16
- Product number
- 072423
- Product name
- 1,3-Dibromoisoquinoline
- Purity
- 95+%
- Packaging
- 1g
- Price
- $201
- Updated
- 2021/12/16
1,3-DIBROMOISOQUINOLINE Chemical Properties,Usage,Production
Synthesis
4456-77-3
53987-60-3
General procedure for the synthesis of 1,3-dibromoisoquinoline from 1,3-[2H,4H]-isoquinolinedione: A mixture of 1,3-[2H,4H]-isoquinolinedione (20a, 0.65 g, 4.02 mmol), phosphorus tribromide (1.51 mL, 16.05 mmol) and phosphorus tribromide (1.04 g, 3.61 mmol) was reacted at 180°C The reaction was stirred for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature, slowly poured into ice water and the pH was adjusted to 8-9 with aqueous 2 N potassium hydroxide. subsequently, the aqueous layer was extracted with toluene and the organic layer was filtered through a neutral alumina column. Finally, the filtrate was evaporated to give the title compound 1,3-dibromoisoquinoline (0.58 g, 56% yield) as a white solid.LRMS (m/z): 286/288/290 (M + 1)+.1H NMR (400 MHz, chloroform-d) δ ppm: 7.67-7.76 (m, 3H), 7.84 (s, 1H), 8.24 (d, J = 8.40 Hz, 1H).
References
[1] Patent: US6340759, 2002, B1. Location in patent: Example 28
[2] Patent: WO2012/41476, 2012, A1. Location in patent: Page/Page column 56-57
[3] Patent: EP2441755, 2012, A1. Location in patent: Paragraph 0172
[4] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 17, p. 5891 - 5908
1,3-DIBROMOISOQUINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1,3-DIBROMOISOQUINOLINE manufacturers
- Product
- 1,3-DIBROMOISOQUINOLINE 53987-60-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KG
- Release date
- 2020-01-07