ChemicalBook > CAS DataBase List > 1,3-DIBROMOISOQUINOLINE

1,3-DIBROMOISOQUINOLINE

Product Name
1,3-DIBROMOISOQUINOLINE
CAS No.
53987-60-3
Chemical Name
1,3-DIBROMOISOQUINOLINE
Synonyms
1,3-Dibromoisoquineline;1,3-DIBROMOISOQUINOLINE;Isoquinoline, 1,3-dibromo-;1,3-Dibromoisoquinoline 98%;1,3-DIBROMOISOQUINOLINE ISO 9001：2015 REACH
CBNumber
CB9444100
Molecular Formula
C9H5Br2N
Formula Weight
286.95
MOL File
53987-60-3.mol
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1,3-DIBROMOISOQUINOLINE Property

Boiling point:
370.9±22.0 °C(Predicted)
Density 
1.923±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-1.49±0.50(Predicted)
Appearance
White to yellow Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Usbiological
Product number
411035
Product name
1,3-Dibromoisoquinoline
Packaging
100mg
Price
$305
Updated
2021/12/16
TRC
Product number
D425513
Product name
1,3-Dibromoisoquinoline
Packaging
1g
Price
$200
Updated
2021/12/16
Matrix Scientific
Product number
072423
Product name
1,3-Dibromoisoquinoline
Purity
95+%
Packaging
1g
Price
$201
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD42237
Product name
1,3-Dibromoisoquinoline
Packaging
500mg
Price
$300
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD42237
Product name
1,3-Dibromoisoquinoline
Packaging
1g
Price
$478.6
Updated
2021/12/16
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1,3-DIBROMOISOQUINOLINE Chemical Properties,Usage,Production

Synthesis

4456-77-3

53987-60-3

General procedure for the synthesis of 1,3-dibromoisoquinoline from 1,3-[2H,4H]-isoquinolinedione: A mixture of 1,3-[2H,4H]-isoquinolinedione (20a, 0.65 g, 4.02 mmol), phosphorus tribromide (1.51 mL, 16.05 mmol) and phosphorus tribromide (1.04 g, 3.61 mmol) was reacted at 180°C The reaction was stirred for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature, slowly poured into ice water and the pH was adjusted to 8-9 with aqueous 2 N potassium hydroxide. subsequently, the aqueous layer was extracted with toluene and the organic layer was filtered through a neutral alumina column. Finally, the filtrate was evaporated to give the title compound 1,3-dibromoisoquinoline (0.58 g, 56% yield) as a white solid.LRMS (m/z): 286/288/290 (M + 1)+.1H NMR (400 MHz, chloroform-d) δ ppm: 7.67-7.76 (m, 3H), 7.84 (s, 1H), 8.24 (d, J = 8.40 Hz, 1H).

References

[1] Patent: US6340759, 2002, B1. Location in patent: Example 28
[2] Patent: WO2012/41476, 2012, A1. Location in patent: Page/Page column 56-57
[3] Patent: EP2441755, 2012, A1. Location in patent: Paragraph 0172
[4] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 17, p. 5891 - 5908

1,3-DIBROMOISOQUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1,3-DIBROMOISOQUINOLINE manufacturers

Career Henan Chemical Co
Product
1,3-DIBROMOISOQUINOLINE 53987-60-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000KG
Release date
2020-01-07

53987-60-3, 1,3-DIBROMOISOQUINOLINERelated Search:

3-BROMOISOQUINOLINE 1-Bromoisoquinoline 1,3-DIBROMOISOQUINOLIN-4-YLAMINE 2,6-Dibromopyridine 1,3-DIBROMOISOQUINOLINE

  • 1,3-DIBROMOISOQUINOLINE
  • 1,3-Dibromoisoquineline
  • Isoquinoline, 1,3-dibromo-
  • 1,3-DIBROMOISOQUINOLINE ISO 9001：2015 REACH
  • 1,3-Dibromoisoquinoline 98%
  • 53987-60-3