8-Bromoisoquinoline

Product Name: 8-Bromoisoquinoline
CAS No.: 63927-22-0
Chemical Name: 8-Bromoisoquinoline
Synonyms: 8-BromoisoquinoL;8-BROMOISOQUINOLINE;Isoquinoline, 8-bromo-;8-Bromoisoquinoline 95%;8-Bromoisoquinoline >8-Bromoisoquinoline ,97%;8-Bromo-isoquinoline()/98%/50g;8-Bromoisoquinoline ISO 9001：2015 REACH
CBNumber: CB5217212
Molecular Formula: C9H6BrN
Formula Weight: 208.05
MOL File: 63927-22-0.mol

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8-Bromoisoquinoline Property

Melting point:: 80,5 C
Boiling point:: 312.3±15.0 °C(Predicted)
Density: 1.564±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:8): .5 mg/ml
form: powder to crystal
pka: 4.63±0.23(Predicted)
color: Light orange to Yellow to Green
InChI: InChI=1S/C9H6BrN/c10-9-3-1-2-7-4-5-11-6-8(7)9/h1-6H
InChIKey: DPRIHFQFWWCIGY-UHFFFAOYSA-N
SMILES: C1C2=C(C=CC=C2Br)C=CN=1
CAS DataBase Reference: 63927-22-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn,T
Risk Statements: 36/37/38-20/21/22-25
Safety Statements: 26-36-45
RIDADR: 2811
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: Ⅲ
HS Code: 29334900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B4144
Product name: 8-Bromoisoquinoline
Purity: >97.0%(GC)(T)
Packaging: 1g
Price: $48
Updated: 2025/07/31

TCI Chemical

Product number: B4144
Product name: 8-Bromoisoquinoline
Purity: >97.0%(GC)(T)
Packaging: 5g
Price: $188
Updated: 2025/07/31

Cayman Chemical

Product number: 10007082
Product name: 8-Bromoisoquinoline
Purity: ≥99%
Packaging: 500mg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 10007082
Product name: 8-Bromoisoquinoline
Purity: ≥99%
Packaging: 1g
Price: $53
Updated: 2024/03/01

Cayman Chemical

Product number: 10007082
Product name: 8-Bromoisoquinoline
Purity: ≥99%
Packaging: 5g
Price: $209
Updated: 2023/01/06

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8-Bromoisoquinoline Chemical Properties,Usage,Production

Chemical Properties

Yellow powder

Uses

8-Bromoisoquinoline is an intermediate used to prepare 4-?((2-?Hydroxy-?3-?methoxybenzyl)?amino)?benzenesulfonamide derivatives as potent and selective inhibitors of 12-?Lipoxygenase. It is also used in the synthesis of selective excitatory amino acid transporter subtype 1 (EAAT1) Inhibitor UCPH-?102.

Synthesis

6630-33-7

22483-09-6

63927-22-0

1. 2-Bromobenzaldehyde (50 g, 270 mmol), aminoglyoxal dimethyl acetal (28.4 g, 270 mmol) and toluene (400 mL) were mixed under argon protection and heated to reflux. The dehydration reaction was carried out for 2.0 hours using a Dean-Stark apparatus. After dehydration was completed, reflux was continued for 1.0 hour. 2. Upon completion of the reaction, toluene was removed by evaporation under reduced pressure, the residue was dissolved in dichloromethane (600 mL), and the solution was cooled to 0°C. The reaction was then purged by evaporation under reduced pressure. 3. Aluminum chloride (118.9 g, 891.7 mmol) was slowly added to the cooled solution under argon protection, and the reaction mixture was then stirred at 45°C for 2.0 hours. 4. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the mixture was cooled to room temperature and slowly poured into ice water. 5. The dichloromethane layer was separated by alkalizing the mixture with 10% sodium hydroxide solution. The aqueous layer was re-extracted with dichloromethane (2 x 100mL). 6. The methylene chloride layer was combined, washed with brine and dried over anhydrous sodium sulfate. 7. The dichloromethane was removed by evaporation and the residue was purified by column chromatography on silica gel (100-200 mesh) to afford 8-bromoisoquinoline as an off-white solid (28 g, 49.8% yield) using a 5-8% ethyl acetate solution in hexane as the mobile phase. MS (ESI) m/z: 208 [M(79Br)+1], 210 [M(81Br)+1]; 1H NMR (400 MHz, DMSO-d6): δ 7.17 (t, J=7.8 Hz, 1H); 7.91 (d, J=6.0 Hz, 1H); 8.02 (d, J=8.4 Hz, 1H); 8.05 (d, J= 8.8 Hz, 1H); 8.65 (d, J=5.2 Hz, 1H); 9.48 (s, 1H).

References

[1] Patent: WO2016/21742, 2016, A1. Location in patent: Paragraph 0222; 0223

8-Bromoisoquinoline Preparation Products And Raw materials

Raw materials

Isoquinoline Ammonium hydroxide N-Bromosuccinimide N,N-Dimethylformamide Potassium iodide Triethylamine Palladium Sodium nitrite 2-Bromobenzaldehyde Hydrochloric acid Methanol Sodium hydroxide Phosphorus pentoxide 2,2-Diethoxyethylamine Sulfuric acid Potassium nitrate

Preparation Products

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8-Bromoisoquinoline Suppliers

Americas 1 Canada 1 CHINA 223 Europe 2 France 1 Germany 4 India 11 Japan 1 United Kingdom 14 United States 38 Global 296

Shanghai Licheng Chemical Co., Ltd.

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J & K SCIENTIFIC LTD.

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Bridge Organics

Tel: +1269-649-4200
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ITIC MEDCHEM(SUZHOU) CO.,LTD.

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Energy Chemical

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Beijing Ouhe Technology Co., Ltd

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JinYan Chemicals(ShangHai) Co.,Ltd.

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View Lastest Price from 8-Bromoisoquinoline manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 8-Bromoisoquinoline 63927-22-0
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 100kg
Release date: 2025-06-13

Hebei Chuanghai Biotechnology Co., Ltd

Product: 8-Bromoisoquinoline 63927-22-0
Price: US $9.80/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 tons
Release date: 2024-10-25

Henan Aochuang Chemical Co.,Ltd.

Product: 8-Bromoisoquinoline 63927-22-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-10

63927-22-0, 8-BromoisoquinolineRelated Search:

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8-BROMOISOQUINOLINE

8-Bromoisoquinoline 95%

Isoquinoline, 8-bromo-

8-Bromoisoquinoline ,97%

8-Bromoisoquinoline &gt

8-BromoisoquinoL

8-Bromoisoquinoline ISO 9001：2015 REACH

8-Bromo-isoquinoline()/98%/50g

63927-22-0

16567-18-2

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