5,8-Dibromoisoquinoline

Product Name: 5,8-Dibromoisoquinoline
CAS No.: 81045-39-8
Chemical Name: 5,8-Dibromoisoquinoline
Synonyms: 5,8-Dibromoisoquinoline;Isoquinoline, 5,8-dibromo-;5,8-Dibromoisoquinoline98%;5,8-Dibromoisoquinoline 98%;5,8-Dibromoisoquinoline ISO 9001：2015 REACH
CBNumber: CB6957906
Molecular Formula: C9H5Br2N
Formula Weight: 286.95
MOL File: 81045-39-8.mol

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5,8-Dibromoisoquinoline Property

Boiling point:: 363.7±22.0 °C(Predicted)
Density: 1.923±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 3.65±0.36(Predicted)
form: Solid
Appearance: White to off-white Solid

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Safety

Hazard Codes: Xi
Hazard Note: Irritant
HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: D425568
Product name: 5,8-Dibromoisoquinoline
Packaging: 500mg
Price: $110
Updated: 2021/12/16

TRC

Product number: D425568
Product name: 5,8-Dibromoisoquinoline
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: OR8298
Product name: 5,8-Dibromoisoquinoline
Purity: 98%
Packaging: 1g
Price: $70
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-9-T2
Product name: 5,8-Dibromoisoquinoline
Purity: 98%
Packaging: 1g
Price: $77
Updated: 2021/12/16

AK Scientific

Product number: W8567
Product name: 5,8-Dibromoisoquinoline
Packaging: 250mg
Price: $99
Updated: 2021/12/16

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5,8-Dibromoisoquinoline Chemical Properties,Usage,Production

Synthesis

119-65-3

81045-39-8

Isoquinoline (13a) (1.83 mL, 15.50 mmol) was slowly added dropwise to concentrated sulfuric acid (17 mL) at 0 °C while maintaining stirring. The reaction mixture was cooled to -25 °C, followed by the addition of sodium borohydride (6.34 g, 35.65 mmol) in batches, with the rate of addition controlled to maintain the reaction temperature between -25 °C and -20 °C. The reaction was continued for 1 hour at this temperature. After the reaction was continued at this temperature for 1 h, the reaction mixture was allowed to warm up naturally to room temperature. The reaction mixture was carefully poured into crushed ice and the pH was adjusted with concentrated aqueous ammonia solution to 7.0. The resulting slurry was stirred at 0°C for 1 hr and subsequently filtered and washed with ice water. The crude product was air dried and purified by column chromatography to afford 5,8-dibromoisoquinoline (13b) (2.5 g, 56%). Mass spectrum (EI) m/z: 286 ([M+1]+). 1H NMR (400 MHz, DMSO-d6) δ: 9.48 (s, 1H), 8.78 (d, J = 6 Hz, 1H), 8.06 (d, J = 8 Hz, 1H), 7.98 (dd, J = 6 Hz, J = 8 Hz, 2H).

References

[1] Organic Letters, 2017, vol. 19, # 1, p. 262 - 265
[2] Journal of Materials Chemistry C, 2015, vol. 3, # 22, p. 5835 - 5843
[3] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 16, p. 4026 - 4030
[4] Patent: WO2013/5157, 2013, A1. Location in patent: Page/Page column 36; 37
[5] Polymer, 2011, vol. 52, # 26, p. 6029 - 6036

5,8-Dibromoisoquinoline Preparation Products And Raw materials

Raw materials

Preparation Products

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5,8-Dibromoisoquinoline Suppliers

China 82 Germany 1 India 2 Russia 1 The Netherlands 1 United Kingdom 2 United States 9 Global 98

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View Lastest Price from 5,8-Dibromoisoquinoline manufacturers

Career Henan Chemical Co

Product: 5,8-Dibromoisoquinoline 81045-39-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Kg/T
Release date: 2019-12-19

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5,8-Dibromoisoquinoline ISO 9001：2015 REACH

81045-39-8

C9H5Br2N

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