Methyl 4-cyanobicyclo[2.2.2]octane-1-carboxylate
- Product Name
- Methyl 4-cyanobicyclo[2.2.2]octane-1-carboxylate
- CAS No.
- 54202-05-0
- Chemical Name
- Methyl 4-cyanobicyclo[2.2.2]octane-1-carboxylate
- Synonyms
- Methyl 4-cyanobicyclo[2.2.2]octane-1-carboxylate;Bicyclo[2.2.2]octane-1-carboxylic acid, 4-cyano-, methyl ester
- CBNumber
- CB72734438
- Molecular Formula
- C11H15NO2
- Formula Weight
- 193.24
- MOL File
- 54202-05-0.mol
Methyl 4-cyanobicyclo[2.2.2]octane-1-carboxylate Property
- Boiling point:
- 292.6±40.0 °C(Predicted)
- Density
- 1.13±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 7793AB
- Product name
- Methyl4-cyanobicyclo[2.2.2]octane-1-carboxylate
- Packaging
- 250mg
- Price
- $336
- Updated
- 2021/12/16
- Product number
- CHM0393164
- Product name
- METHYL-4-CYANOBICYCLO[2.2.2]OCTANE-1-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.53
- Updated
- 2021/12/16
- Product number
- AS111306
- Product name
- Methyl4-cyanobicyclo[2.2.2]octane-1-carboxylate
- Purity
- 95%
- Packaging
- 1g
- Price
- $655
- Updated
- 2021/12/16
- Product number
- CM201446
- Product name
- methyl4-cyanobicyclo[2.2.2]octane-1-carboxylate
- Purity
- 95%
- Packaging
- 1g
- Price
- $499
- Updated
- 2021/12/16
- Product number
- CD13011173
- Product name
- Methyl4-cyanobicyclo[2.2.2]octane-1-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $529
- Updated
- 2021/12/16
Methyl 4-cyanobicyclo[2.2.2]octane-1-carboxylate Chemical Properties,Usage,Production
Synthesis
135908-42-8
54202-05-0
The general procedure for the synthesis of methyl 4-cyanobicyclo[2.2.2]octane-1-carboxylate from methyl 4-carbamoylbicyclo[2.2.2]octane-1-carboxylate was as follows: to a solution of pyridine (10 mL) containing methyl 4-carbamoylbicyclo[2.2.2]octane-1-carboxylate (228 mg) and imidazole (147 mg) was slowly added, at 0 °C, a solution of phosphorus oxychloride (POCl3, 0.40 mL). The reaction mixture was stirred continuously at 0 °C for 1 hour. Subsequently, the reaction mixture was poured into a mixture containing ice, sodium chloride (NaCl) and ethyl acetate (EtOAc). The organic phase was separated and washed with aqueous 1N hydrochloric acid until the aqueous phase was acidic. The organic phase was dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated to afford the target product methyl 4-cyanobicyclo[2.2.2]octane-1-carboxylate (137 mg, 72% yield). Mass spectral analysis showed [MH]+ = 194.
References
[1] Patent: WO2006/128184, 2006, A2. Location in patent: Page/Page column 166
[2] Patent: WO2008/63671, 2008, A2. Location in patent: Page/Page column 178-179
[3] Patent: WO2008/100423, 2008, A1. Location in patent: Page/Page column 82-83
Methyl 4-cyanobicyclo[2.2.2]octane-1-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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