MICROCYSTIN YR Property

Density 

1.33±0.1 g/cm3(Predicted)

Flash point:

11 °C

storage temp. 

−20°C

solubility 

methanol: 2  mg/mL (further dilute to 10% (v/v) methanol)

form 

white powder

pka

3.02±0.70(Predicted)

EPA Substance Registry System

Cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-tyrosyl-(3S)-3-methyl-D-.beta.-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-.gamma.-glutamyl] (101064-48-6)

Safety

Hazard Codes 

T+,T,F

Risk Statements 

26/27/28-36/37/38-43-39/23/24/25-23/24/25-11

Safety Statements 

26-36/37/39-45-36/37-16-7

RIDADR 

UN 2811 6.1/PG 1

WGK Germany 

3

RTECS 

000000030272

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H300Fatal if swallowed

H301Toxic if swalloed

H310Fatal in contact with skin

H311Toxic in contact with skin

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H330Fatal if inhaled

H331Toxic if inhaled

H335May cause respiratory irritation

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P350IF ON SKIN: Gently wash with plenty of soap and water.

P311Call a POISON CENTER or doctor/physician.

MICROCYSTIN YR Chemical Properties,Usage,Production

Uses

Microcystin YR from Microcystis aeruginosa has been used to assess cytotoxicity in neutrophils using DNA fragmentation and cell viability assays and as a reference standard in the quantification of microcystin from water samples.

General Description

Microcystin is a potent cyanotoxin produced by the bloom of Microcystis aeruginosa. It is harmful to aquatic animals. It is a heptapeptide and exists as multiple variant forms. pCO₂ and nitrogen levels modulate the toxic variants levels. It elicits damage to the liver and other organs.

Biochem/physiol Actions

Microcystin YR inhibits protein phosphatase type 2A and protein phosphatase type 1. Toxicity to undifferentiated cells was seen by inhibition of neutral red uptake, >80% at 100 μM, after 48 h.