NODULARIN

Product Name: NODULARIN
CAS No.: 118399-22-7
Chemical Name: NODULARIN
Synonyms: NODULARIN;Nodularin-R solution;Nodularin solution ;IXBQSRWSVIBXNC-HSKGSTCASA-N;Nodularin, Nodularia spumigena;yl-10-phenyl-3-aminodecanoyl-d-gamma-glutamyl);1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide;Nodularin,1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide;1,4,8,11,15-PENTAAZACYCLONONADECANE, CYCLIC PEPTIDE DERIVATIVE;tyl-l-arginyl-(2s,3s,4e,6e,8s,9s)-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimeth
CBNumber: CB6225379
Molecular Formula: C41H60N8O10
Formula Weight: 824.96
MOL File: 118399-22-7.mol

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NODULARIN Property

Density: 1.29±0.1 g/cm3(Predicted)
Flash point:: 11℃
storage temp.: −20°C
solubility: methanol: 2 mg/mL Further dilute to 10% (v/v) methanol. Store solutions at −20°C for up to six months.
form: Dry residue containing traces of monobasic potassium phosphate.
pka: 3.39±0.70(Predicted)
IARC: 3 (Vol. 94) 2010
EPA Substance Registry System: Nodularin (118399-22-7)

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Safety

Hazard Codes: T,F,T+
Risk Statements: 23/24/25-38-39/23/24/25-11-43-36/37/38-26/27/28
Safety Statements: 36/37-45-16-7-36/37/39-26
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
RTECS: GU2294250
Hazardous Substances Data: 118399-22-7(Hazardous Substances Data)
Toxicity: mouse,LD50,intraperitoneal,60ug/kg (0.06mg/kg),Chemical Research in Toxicology. Vol. 6, Pg. 151, 1993.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N5148
Product name: Nodularin
Purity: cyanotoxin
Packaging: 250μg
Price: $638
Updated: 2024/03/01

Sigma-Aldrich

Product number: 32539
Product name: Nodularin solution
Purity: 10μg/mL in methanol, analytical standard
Packaging: 1ml
Price: $590
Updated: 2024/03/01

Cayman Chemical

Product number: 10007190
Product name: Nodularin
Purity: ≥95%
Packaging: 100μg
Price: $138
Updated: 2024/03/01

Usbiological

Product number: 170023
Product name: Nodularin
Packaging: 100ug
Price: $325
Updated: 2021/12/16

TRC

Product number: N634260
Product name: Nodularin
Packaging: 1mg
Price: $1320
Updated: 2021/12/16

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NODULARIN Chemical Properties,Usage,Production

Description

The cyanobacterium Nodularia spumigena often contaminates the drinking water of rural communities in developing countries and accumulates in mussels, flounder, and cod from the northern Baltic Sea. Nodularin is a hepatotoxic monocylic pentapeptide produced by the N. spumigena. It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC₅₀ values of 1.8 and 0.026 nM, respectively. PP2B is inhibited to a lesser extent with an IC₅₀ of 1.8 μM. No apparent inhibitory effect is observed with PP2C, alkaline phosphatase, acid phosphatase, insulin receptor tyrosine kinase, protein kinase A, phosphorylase kinase, or protein kinase C.

Uses

Nodularin-R is a cyclic peptide toxin produced by freshwater cyanobacteria.

Definition

Toxin produced by blue green algae.

NODULARIN Preparation Products And Raw materials

Raw materials

Preparation Products

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NODULARIN Suppliers

China 36 Germany 1 Switzerland 3 United States 5 Global 45

Shanghai EFE Biological Technology Co., Ltd.

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Shanghai Hongye Biotechnology Co. Ltd

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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MedBioPharmaceutical Technology Inc

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cjbscvictory

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Naturewill Biotechnology Co., Ltd.

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Guangzhou Yaoguang Technology Co., Ltd.

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TargetMol Chemicals Inc.

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118399-22-7, NODULARINRelated Search:

Tris(2,4-pentanedionato)chroMiuM(III) PHENYLSELENOL METHYL ISOCYANOACETATE 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE Tosylmethyl isocyanide SALCOMINE N-BUTYLISOCYANIDE Cupric acetylacetonate Benzyl isocyanide Aluminum acetylacetonate 2,4-PENTANEDIONE, SILVER DERIVATIVE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Ferric acetylacetonate DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) TERT-BUTYL ISOCYANIDE COBALT(II) ACETYLACETONATE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) Ethyl isocyanoacetate

tyl-l-arginyl-(2s,3s,4e,6e,8s,9s)-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimeth

yl-10-phenyl-3-aminodecanoyl-d-gamma-glutamyl)

NODULARIN

1,4,8,11,15-PENTAAZACYCLONONADECANE, CYCLIC PEPTIDE DERIVATIVE

Nodularin, Nodularia spumigena

1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide

Cyclo((Z)-2,3-didehydro-N-methyl-2-aminobutanoyl-erythro-3-methyl-D-beta-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyl-3-aminodecanoyl-D-gamma-glutamyl)

Cyclo(L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-gamma-glutamyl-(2Z)-2-(methylamino)-2-butenoyl-(3S)-3-methyl-D-beta-aspartyl)

Nodularin,1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide

Nodularin-R solution

Nodularin solution

cyclo((z)-2,3-didehydro-n-methyl-2-aminobutanoyl-erythro-3-methyl-d-beta-aspar

IXBQSRWSVIBXNC-HSKGSTCASA-N

Cyclo[(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl-(2Z)-2-(methylamino)-2-butenoyl-(3S)-3-methyl-D-β-aspartyl-L-arginyl]

118399-22-7

C41H60N8O10

Application Index

Biochemicals and Reagents

BioChemical

Cell Signaling Enzymes

Cyanobacterial Toxins

Enzymes, Inhibitors, and Substrates

Natural Products