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NODULARIN

Product Name
NODULARIN
CAS No.
118399-22-7
Chemical Name
NODULARIN
Synonyms
NODULARIN;Nodularin-R solution;Nodularin in methanol;Nodularin solution ;IXBQSRWSVIBXNC-HSKGSTCASA-N;Nodularin, Nodularia spumigena;yl-10-phenyl-3-aminodecanoyl-d-gamma-glutamyl);1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide;Nodularin,1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide;1,4,8,11,15-PENTAAZACYCLONONADECANE, CYCLIC PEPTIDE DERIVATIVE
CBNumber
CB6225379
Molecular Formula
C41H60N8O10
Formula Weight
824.96
MOL File
118399-22-7.mol
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NODULARIN Property

Density 
1.29±0.1 g/cm3(Predicted)
Flash point:
11℃
storage temp. 
−20°C
solubility 
methanol: 2 mg/mL Further dilute to 10% (v/v) methanol. Store solutions at −20°C for up to six months.
form 
Dry residue containing traces of monobasic potassium phosphate.
pka
3.39±0.70(Predicted)
IARC
3 (Vol. 94) 2010
EPA Substance Registry System
Nodularin (118399-22-7)
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Safety

Hazard Codes 
T,F,T+
Risk Statements 
23/24/25-38-39/23/24/25-11-43-36/37/38-26/27/28
Safety Statements 
36/37-45-16-7-36/37/39-26
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
RTECS 
GU2294250
Hazardous Substances Data
118399-22-7(Hazardous Substances Data)
Toxicity
mouse,LD50,intraperitoneal,60ug/kg (0.06mg/kg),Chemical Research in Toxicology. Vol. 6, Pg. 151, 1993.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N5148
Product name
Nodularin
Purity
cyanotoxin
Packaging
250μg
Price
$638
Updated
2024/03/01
Sigma-Aldrich
Product number
32539
Product name
Nodularin solution
Purity
10μg/mL in methanol, analytical standard
Packaging
1ml
Price
$590
Updated
2024/03/01
Cayman Chemical
Product number
10007190
Product name
Nodularin
Purity
≥95%
Packaging
100μg
Price
$138
Updated
2024/03/01
Usbiological
Product number
170023
Product name
Nodularin
Packaging
100ug
Price
$325
Updated
2021/12/16
TRC
Product number
N634260
Product name
Nodularin
Packaging
1mg
Price
$1320
Updated
2021/12/16
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NODULARIN Chemical Properties,Usage,Production

Description

The cyanobacterium Nodularia spumigena often contaminates the drinking water of rural communities in developing countries and accumulates in mussels, flounder, and cod from the northern Baltic Sea. Nodularin is a hepatotoxic monocylic pentapeptide produced by the N. spumigena. It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC50 values of 1.8 and 0.026 nM, respectively. PP2B is inhibited to a lesser extent with an IC50 of 1.8 μM. No apparent inhibitory effect is observed with PP2C, alkaline phosphatase, acid phosphatase, insulin receptor tyrosine kinase, protein kinase A, phosphorylase kinase, or protein kinase C.

Uses

Nodularin-R is a cyclic peptide toxin produced by freshwater cyanobacteria.

Definition

Toxin produced by blue green algae.

NODULARIN Preparation Products And Raw materials

Raw materials

Preparation Products

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NODULARIN Suppliers

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118399-22-7, NODULARINRelated Search:

Tris(2,4-pentanedionato)chroMiuM(III) PHENYLSELENOL METHYL ISOCYANOACETATE 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE Tosylmethyl isocyanide SALCOMINE N-BUTYLISOCYANIDE Cupric acetylacetonate Benzyl isocyanide Aluminum acetylacetonate 2,4-PENTANEDIONE, SILVER DERIVATIVE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Ferric acetylacetonate DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) TERT-BUTYL ISOCYANIDE COBALT(II) ACETYLACETONATE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) Ethyl isocyanoacetate

  • tyl-l-arginyl-(2s,3s,4e,6e,8s,9s)-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimeth
  • yl-10-phenyl-3-aminodecanoyl-d-gamma-glutamyl)
  • NODULARIN
  • 1,4,8,11,15-PENTAAZACYCLONONADECANE, CYCLIC PEPTIDE DERIVATIVE
  • Nodularin, Nodularia spumigena
  • 1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide
  • Cyclo((Z)-2,3-didehydro-N-methyl-2-aminobutanoyl-erythro-3-methyl-D-beta-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyl-3-aminodecanoyl-D-gamma-glutamyl)
  • Cyclo(L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-gamma-glutamyl-(2Z)-2-(methylamino)-2-butenoyl-(3S)-3-methyl-D-beta-aspartyl)
  • Nodularin,1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide
  • Nodularin-R solution
  • Nodularin solution
  • cyclo((z)-2,3-didehydro-n-methyl-2-aminobutanoyl-erythro-3-methyl-d-beta-aspar
  • IXBQSRWSVIBXNC-HSKGSTCASA-N
  • Cyclo[(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl-(2Z)-2-(methylamino)-2-butenoyl-(3S)-3-methyl-D-β-aspartyl-L-arginyl]
  • Nodularin in methanol
  • 118399-22-7
  • C41H60N8O10
  • Application Index
  • Biochemicals and Reagents
  • BioChemical
  • Cell Signaling Enzymes
  • Cyanobacterial Toxins
  • Enzymes, Inhibitors, and Substrates
  • Natural Products