Finerenone
- Product Name
- Finerenone
- CAS No.
- 1050477-31-0
- Chemical Name
- Finerenone
- Synonyms
- Finerenone;BAY 94-8862;Finerone;(4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide;BAY948862;Fenaridone;Fenalidone;Non Nilidone;D5-Finerenone;Mr Neri ketone
- CBNumber
- CB72744895
- Molecular Formula
- C21H22N4O3
- Formula Weight
- 378.42
- MOL File
- 1050477-31-0.mol
Finerenone Property
- Boiling point:
- 554.7±50.0 °C(Predicted)
- Density
- 1.29±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMF: 10 mg/ml DMSO: 3 mg/ml Ethanol: insol PBS (pH 7.2): insol
- pka
- 14.76±0.40(Predicted)
- form
- solid
- color
- White to off-white
- λmax
- 255 nm
- InChI
- InChI=1S/C21H22N4O3/c1-5-28-21-18-17(14-7-6-13(9-22)8-15(14)27-4)16(20(23)26)12(3)25-19(18)11(2)10-24-21/h6-8,10,17,25H,5H2,1-4H3,(H2,23,26)/t17-/m1/s1
- InChIKey
- BTBHLEZXCOBLCY-QGZVFWFLSA-N
- SMILES
- N1C2=C(C(OCC)=NC=C2C)[C@H](C2=CC=C(C#N)C=C2OC)C(C(N)=O)=C1C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H360May damage fertility or the unborn child
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-0040097
- Product name
- Finerenone
- Purity
- 99.75%
- Packaging
- 5mg
- Price
- $480
- Updated
- 2021/12/16
- Product number
- CS-0040097
- Product name
- Finerenone
- Purity
- 99.75%
- Packaging
- 10mg
- Price
- $800
- Updated
- 2021/12/16
- Product number
- CS-0040097
- Product name
- Finerenone
- Purity
- 99.75%
- Packaging
- 25mg
- Price
- $1550
- Updated
- 2021/12/16
- Product number
- CS-0040097
- Product name
- Finerenone
- Purity
- 99.75%
- Packaging
- 50mg
- Price
- $2400
- Updated
- 2021/12/16
- Product number
- CS-0040097
- Product name
- Finerenone
- Purity
- 99.75%
- Packaging
- 100mg
- Price
- $3600
- Updated
- 2021/12/16
Finerenone Chemical Properties,Usage,Production
Description
Finerenone is a novel mineralocorticoid receptor antagonist that has the effect of delaying the progression of chronic kidney disease. Some people may be aware of two other mineralocorticoid receptor antagonists: the diuretic antihypertensive drug spironolactone, and eplerenone.Finerenone is their cognate derivative and is a third-generation mineralocorticoid receptor antagonist. So far, finerenone is the only nonsteroidal mineralocorticoid receptor antagonist to be FDA approved. Finerenone was granted FDA approval on 9 July 2021, followed by the EMA approval on 11 March 2022.
Uses
Finerenone is the first non-steroidal selective mineralocorticoid receptor antagonist, which can be used for the treatment of diabetic nephropathy, chronic kidney disease and end-stage renal disease. It can reduce the proteinuria of patients and improve the glomerular filtration rate.
Indications
Finerenone is used for the treatment of adult patients with chronic kidney disease (CKD) associated with type 2 diabetes (T2D). Finerenone's indication is to reduce the risk of sustained estimated glomerular filtration rate decline, end-stage renal disease, end-stage renal disease, cardiovascular death, non-fatal myocardial infarction, and risk of hospitalisation for heart failure.
brand name
Finerenone is sold under the brand name Kerendia and Firialta.
Biological Activity
Finerenone (FIN, BAY 94-8862) is a highly selective, orally active, nonsteroidal antagonist of mineralocorticoid receptor (MR) with IC50 of 18 nM. Finerenone has the potential to study cardio-renal diseases such as type 2 diabetes and chronic kidney disease.
Synthesis
Synthesis scheme of finerenone: Firstly, benzaldehyde 20.1 was condensed with acetoacetamide under Knoevenagel condensation conditions to give high yield of ketone 20.2 of undetermined structure.Meanwhile, pyridinyl chloride 20.3 was treated at high temperature with strong alkali conditions followed by treatment with strong acid at low temperature to give filterable pyridinone solid 20.4.
Addition of 20.2 to a heated isobutanol solution of 20.4 resulted in a condensation-cyclisation reaction to give the nitrogen-containing heterocyclic compound 20.5 in good yield. The conversion of the pyridone to the corresponding ether was achieved by treating the pyridone with 1,1,1-triethoxyethane under acidic conditions. Some of the synthetic methods for fenaridones were carried out by chromatographic separation of the racemate 20.6, while a recent patent reports a classical splitting using tartaric acid derived salts. In one example, 20.6 was reacted with p-toluoyl-d-tartaric acid in a mixture of ethanol and water to give the target enantiomer in 78% enantiomeric excess, which was purified to 99% enantiomeric excess by re-suspension in ethanol and water to ultimately give 20.7 in about 41% yield. Adjusting the pH in water and ethanol with sodium carbonate gave the free base of fenaridone (20) in 97% yield.
in vivo
Finerenone (BAY 94-8862) lowers albuminuria by >40% and significantly reduces systolic blood pressure (SBP) in Munich Wistar Fr?mter (MWF) rat.
Mode of action
Finerenone is a Nonsteroidal Mineralocorticoid-Receptor Antagonist. The mechanism of action of finerenone is as a Mineralocorticoid Receptor Antagonist. Finerenone inhibits the effects of mineralocorticoids like aldosterone and cortisol when the MR is overactivated, possibly reducing inflammation and fibrosis in the heart and kidney.
References
Kolkhof, P., Hartmann, E., Freyberger, A., et al.Effects of finerenone combined with empagliflozin in a model of hypertension-induced end-organ damage. Am. J. Nephrol. 52(8), 642-652 (2021).
DOI: 10.1159/000516213
Cardiovascular Events with Finerenone in Kidney Disease and Type 2 Diabetes.
Finerenone Preparation Products And Raw materials
Raw materials
Preparation Products
Finerenone Suppliers
- Tel
- 18866891188
- zhaojiangxia@shiningpharm.com
- Country
- China
- ProdList
- 172
- Advantage
- 58
- Tel
- 025-58741518 13327727315
- yao_dongyuan@vcarepharmatech.com
- Country
- China
- ProdList
- 19
- Advantage
- 58
- Tel
- 0571-86828652 18857119830
- Fax
- 0571-83522824
- sales@chemtrue-bio.com
- Country
- China
- ProdList
- 252
- Advantage
- 58
- Tel
- 010-57862036 18811083386
- msales@mesochem.com
- Country
- China
- ProdList
- 210
- Advantage
- 58
- Tel
- 025-58741518 13327700685
- sales@vcarepharmatech.com
- Country
- China
- ProdList
- 495
- Advantage
- 58
- Tel
- 0531-88993893 13335127975
- Fax
- QQ:787658403
- fairouz@sdsihuanpharm.com
- Country
- China
- ProdList
- 82
- Advantage
- 58
- Tel
- 0573-87390950 13806705416
- wzj@alicornpharma.com
- Country
- China
- ProdList
- 57
- Advantage
- 58
- Tel
- 519-88821493 18915891730
- shm@czpharma.com
- Country
- China
- ProdList
- 170
- Advantage
- 58
- Tel
- 18660188356
- Fax
- 0531-88259693
- 2820602043@qq.com
- Country
- China
- ProdList
- 110
- Advantage
- 58
- Tel
- 13127581762 13127581762
- peilingchem@sina.com
- Country
- China
- ProdList
- 554
- Advantage
- 58
View Lastest Price from Finerenone manufacturers
- Product
- Finerenone 1050477-31-0
- Price
- US $5.00-0.50/KG
- Min. Order
- 1KG
- Purity
- 99% hplc
- Supply Ability
- 500TONS
- Release date
- 2025-05-30
- Product
- Finerenone 1050477-31-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 500kg
- Release date
- 2025-03-04
- Product
- Finerenone 1050477-31-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- ＞99% by HPLC
- Supply Ability
- 10kg/month
- Release date
- 2023-01-06