Finerenone
- Product Name
- Finerenone
- CAS No.
- 1050477-31-0
- Chemical Name
- Finerenone
- Synonyms
- Finerenone;BAY 94-8862;Finerone;(4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide;BAY948862;Fenaridone;Fenalidone;Non Nilidone;Mr Neri ketone;Finerenone Inn
- CBNumber
- CB72744895
- Molecular Formula
- C21H22N4O3
- Formula Weight
- 378.42
- MOL File
- 1050477-31-0.mol
Finerenone Property
- Boiling point:
- 554.7±50.0 °C(Predicted)
- Density
- 1.29±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMF: 10 mg/ml DMSO: 3 mg/ml Ethanol: insol PBS (pH 7.2): insol
- pka
- 14.76±0.40(Predicted)
- form
- solid
- color
- White to off-white
- λmax
- 255 nm
- InChI
- InChI=1S/C21H22N4O3/c1-5-28-21-18-17(14-7-6-13(9-22)8-15(14)27-4)16(20(23)26)12(3)25-19(18)11(2)10-24-21/h6-8,10,17,25H,5H2,1-4H3,(H2,23,26)/t17-/m1/s1
- InChIKey
- BTBHLEZXCOBLCY-QGZVFWFLSA-N
- SMILES
- N1C2=C(C(OCC)=NC=C2C)[C@H](C2=CC=C(C#N)C=C2OC)C(C(N)=O)=C1C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H360May damage fertility or the unborn child
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-0040097
- Product name
- Finerenone
- Purity
- 99.75%
- Packaging
- 5mg
- Price
- $480
- Updated
- 2021/12/16
- Product number
- CS-0040097
- Product name
- Finerenone
- Purity
- 99.75%
- Packaging
- 10mg
- Price
- $800
- Updated
- 2021/12/16
- Product number
- CS-0040097
- Product name
- Finerenone
- Purity
- 99.75%
- Packaging
- 25mg
- Price
- $1550
- Updated
- 2021/12/16
- Product number
- CS-0040097
- Product name
- Finerenone
- Purity
- 99.75%
- Packaging
- 50mg
- Price
- $2400
- Updated
- 2021/12/16
- Product number
- CS-0040097
- Product name
- Finerenone
- Purity
- 99.75%
- Packaging
- 100mg
- Price
- $3600
- Updated
- 2021/12/16
Finerenone Chemical Properties,Usage,Production
Description
Finerenone is a novel mineralocorticoid receptor antagonist that has the effect of delaying the progression of chronic kidney disease. Some people may be aware of two other mineralocorticoid receptor antagonists: the diuretic antihypertensive drug spironolactone, and eplerenone.Finerenone is their cognate derivative and is a third-generation mineralocorticoid receptor antagonist. So far, finerenone is the only nonsteroidal mineralocorticoid receptor antagonist to be FDA approved. Finerenone was granted FDA approval on 9 July 2021, followed by the EMA approval on 11 March 2022.
Uses
Finerenone is the first non-steroidal selective mineralocorticoid receptor antagonist, which can be used for the treatment of diabetic nephropathy, chronic kidney disease and end-stage renal disease. It can reduce the proteinuria of patients and improve the glomerular filtration rate.
brand name
Finerenone is sold under the brand name Kerendia and Firialta.
Biological Activity
Finerenone (FIN, BAY 94-8862) is a highly selective, orally active, nonsteroidal antagonist of mineralocorticoid receptor (MR) with IC50 of 18 nM. Finerenone has the potential to study cardio-renal diseases such as type 2 diabetes and chronic kidney disease.
in vivo
Finerenone (BAY 94-8862) lowers albuminuria by >40% and significantly reduces systolic blood pressure (SBP) in Munich Wistar Fr?mter (MWF) rat.
Mode of action
Finerenone is a Nonsteroidal Mineralocorticoid-Receptor Antagonist. The mechanism of action of finerenone is as a Mineralocorticoid Receptor Antagonist. Finerenone inhibits the effects of mineralocorticoids like aldosterone and cortisol when the MR is overactivated, possibly reducing inflammation and fibrosis in the heart and kidney.
References
Kolkhof, P., Hartmann, E., Freyberger, A., et al.Effects of finerenone combined with empagliflozin in a model of hypertension-induced end-organ damage. Am. J. Nephrol. 52(8), 642-652 (2021).
DOI: 10.1159/000516213
Cardiovascular Events with Finerenone in Kidney Disease and Type 2 Diabetes.
Finerenone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Finerenone manufacturers
- Product
- Finerenone 1050477-31-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- ＞99% by HPLC
- Supply Ability
- 10kg/month
- Release date
- 2023-01-06
- Product
- Finerenone 1050477-31-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%，single impurity＜0.1
- Supply Ability
- 1 ton
- Release date
- 2024-01-04
- Product
- Finerenone 1050477-31-0
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 98% HPLC
- Supply Ability
- 100g
- Release date
- 2023-08-01