CB5083

Product Name: CB5083
CAS No.: 1542705-92-9
Chemical Name: CB5083
Synonyms: CB5083;CS-1553;CB-5083;EOS-61078;CB 5083;CB5083;CB5083; CB-5083; CB 5083.;1-[4-(benzylamino)-5H,7H,8H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-carboxamide;1-[4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methylindole-4-carboxamide;1-(4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carboxamide;1H-Indole-4-carboxamide, 1-[7,8-dihydro-4-[(phenylmethyl)amino]-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-
CBNumber: CB72749007
Molecular Formula: C24H23N5O2
Formula Weight: 413.47
MOL File: 1542705-92-9.mol

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CB5083 Property

Boiling point:: 760.5±70.0 °C(Predicted)
Density: 1.37±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥20.65 mg/mL in DMSO; ≥4.4 mg/mL in EtOH
form: solid
pka: 15.99±0.30(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19311
Product name: CB-5083
Purity: ≥95%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 19311
Product name: CB-5083
Purity: ≥95%
Packaging: 5mg
Price: $132
Updated: 2024/03/01

Cayman Chemical

Product number: 19311
Product name: CB-5083
Purity: ≥95%
Packaging: 10mg
Price: $242
Updated: 2024/03/01

Cayman Chemical

Product number: 19311
Product name: CB-5083
Purity: ≥95%
Packaging: 25mg
Price: $548
Updated: 2024/03/01

Biosynth Carbosynth

Product number: BC177445
Product name: CB 5083 NEW
Packaging: 25mg
Price: $550
Updated: 2021/12/16

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CB5083 Chemical Properties,Usage,Production

Biological Activity

cb-5083 is an orally bioavailable inhibitor of p97. p97 is an aaa-atpase involved in multiple cellular functions such as organelle membrane homotypic fusion and sorting of endosomal cargo. p97 is also known as valosin-containing protein which plays important roles in regulating protein homeostasis [1].

in vitro

cb-5083 is a selective potent inhibitor of p97’s second atpase domain. cb-5083 might compete with atp for the same binding site but may adopt a different orientation[2]. the ic50 of cb-5083 against wild-type (wt) p97 was 15.4 nm. cb-5083 could dose-dependently increase the cytosolic protein degradation in hek293t, a549 and hct116 cell lines [1]. cb-5083 treatment (2.5 μm) of a549 cells for 24h could induce cancer cell death [1].

in vivo

in female nude mice bearing hct116, a549 lung carcinoma, and amo-1 multiple myeloma xenograft tumors, oral administration of cb-5083 (100 mg/kg) for 6 h showed a significant antitumor response in tumors (tgi = 63%, p < 0.0001) [1,2].

IC 50

15.4 nm

storage

Store at -20°C

References

anderson d j, le moigne r, djakovic s, et al. targeting the aaa atpase p97 as an approach to treat cancer through disruption of protein homeostasis[j]. cancer cell, 2015, 28(5): 653-665.zhou h j, wang j, yao b, et al. discovery of a first-in-class, potent, selective, and orally bioavailable inhibitor of the p97 aaa atpase (cb-5083)[j]. journal of medicinal chemistry, 2015, 58(24): 9480-9497.

CB5083 Preparation Products And Raw materials

Raw materials

Preparation Products

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CB5083 Suppliers

China 88 India 1 United States 7 Global 96

Jinan Jiuli Biotechnology Co. , Ltd.

Tel: 2717893647 14768611851
Email: 486064515@qq.com
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Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
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WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

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Email: sales@sun-shinechem.com
Country: China
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Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4654
Advantage: 58

Dtchem Laboratories,（Gan Su）Co.,Ltd.

Tel: 18993966060
Fax: 0943-8288977
Email: sales@techbiochem.com
Country: China
ProdList: 937
Advantage: 61

Shanghai Jian Chao Chemical Technology Co., Ltd.

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Fax: qq：2817624287
Email: lyh_antaeus@163.com
Country: China
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Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
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Email: info@chemexpress.com
Country: China
ProdList: 7553
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TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
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Country: China
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SINO High Goal Chemical Technology Co., Ltd.

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Email: sunkai@chembiobanksh.com
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AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2989
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1542705-92-9, CB5083Related Search:

CB5083

CB-5083

1-(4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carboxamide

EOS-61078

CB 5083;CB5083

CS-1553

1-[4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methylindole-4-carboxamide

1-[4-(benzylamino)-5H,7H,8H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-carboxamide

CB5083; CB-5083; CB 5083.

1H-Indole-4-carboxamide, 1-[7,8-dihydro-4-[(phenylmethyl)amino]-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-

1542705-92-9

1542709-92-9