Mesna

Product Name: Mesna
CAS No.: 19767-45-4
Chemical Name: Mesna
Synonyms: SODIUM 2-MERCAPTOETHANESULFONATE;mesnaum;COENZYME M;SodiuM 2-Mercaptoethanesulfonate (Mesna);2-MERCAPTOETHANESULPHONIC ACID SODIUM SALT;MESNA;MESNEX;mesnum;D 7093;Mesina
CBNumber: CB7277461
Molecular Formula: C2H7NaO3S2
Formula Weight: 166.18
MOL File: 19767-45-4.mol

More

Less

Mesna Property

Melting point:: >240°C dec.
storage temp.: 2-8°C
solubility: Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in cyclohexane
form: Solid
color: White to Off-White
Water Solubility: Soluble in water. Also soluble in methanol, DMSO (33 mg/ml) and ethanol (<1 mg/ml).
Merck: 14,5909
BRN: 3657828
Stability:: Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference: 19767-45-4(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 2
RTECS: KI7968000
HS Code: 2930 90 98
Toxicity: LD50 in male, female mice, male, female rats (mg/kg): 1887, 2048, 2098, 1683 i.v.; 2005, 2098, 1529, 1251 i.p.; 6102, >7200, 4440, 4679 orally (Brock)

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M1511
Product name: Sodium 2-mercaptoethanesulfonate
Purity: analytical standard, ≥98.0% (titration)
Packaging: 5g
Price: $79.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: M1511
Product name: Sodium 2-mercaptoethanesulfonate
Purity: analytical standard, ≥98.0% (titration)
Packaging: 10g
Price: $132
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.10595
Product name: Sodium 2-mercaptoethanesulfonate
Purity: for synthesis
Packaging: 10g
Price: $124
Updated: 2024/03/01

Sigma-Aldrich

Product number: 63705
Product name: Sodium 2-mercaptoethanesulfonate
Purity: BioXtra, ≥98.0% (RT)
Packaging: 10G
Price: $192
Updated: 2024/03/01

TCI Chemical

Product number: M0913
Product name: Sodium 2-Mercaptoethanesulfonate
Purity: >95.0%(T)
Packaging: 10g
Price: $93
Updated: 2024/03/01

More

Less

Mesna Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Originator

Mistabronco,UCB,W. Germany,1973

Uses

adrenergic agonist, coronary vasodilator, Ca channel blocker

Uses

Mesna reacts with acrolein and other urotoxic metabolites of oxazaphosphorines (cyclophosphamide or ifosfamide) to form stable, non-urotoxic compounds. Mesna does not have any antitumour activity, nor does it appear to interfere with the antitumour activity of antineoplastic drugs. This medication is used to protect the bladder wall from the harmful effects of some cancer-fighting drugs.

Uses

2-Mercaptoethanesulfonic acid sodium salt (Coenzyme M sodium salt, MESNA) is used as an antioxidant and cytoprotective agent in a wide variety of applications from protection from toxicity of therapeutic agents, such as cyclophosphamide to prevention from brain injury damage.

Definition

ChEBI: Mesna is an organosulfonic acid.

Manufacturing Process

2,100 g of β-S-thiuronium ethanesulfonate were placed in a solution of 2,100 cc of concentrated aqueous ammonia and 400 cc of water. The mixture was carefully warmed on a steam bath and an exothermic reaction ensured, at which point the β-S-thiuronium ethanesulfonate passed into solution. After standing for two hours at room temperature, the solution was concentrated until all of the excess ammonia had been removed.
The resultant clear solution from the ammonolysis reaction was processed through "Amberlite IR-120" ion exchange resin and converted into β-Smercaptoethanesulfonic acid in 93.7% yield (based on β-S-thiuronium ethanesulfonate).
It is expedient not to heat the reaction mixture rapidly since this increases the loss of ammonia and effects an incomplete reaction. Heating the mixture too rapidly may retard the ammonolysis reaction entirely. The amount of ammonia used is considered to be a satisfactory minimum and larger quantities of ammonia are not found to have any beneficial effect on the reaction. It is also expedient to remove the excess ammonia before processing the guanidinium β-mercaptoethanesulfonate solution through the ion exchange resin since the resin will also remove the ammonia with the result that the capacity of the resin for the exchange of guanidinium ions will be reduced.
Although the preparation of β-mercaptoethanesulfonic acid through the ammonolysis reaction is the preferred method, it is also possible to prepare the sulfonic acid by the sodium hydroxide hydrolysis of β-S-thiuronium ethanesulfonate followed by the ion exchange treatment. The resulting acid, however, is generally not as satisfactory as that prepared by the ammonolysis reaction.

brand name

Ausobrone;Mexnex;Mistabronco;Mistabronco;Mistalon;Mucofluid;Mucolene;Uromitexan;Uronexitan.

Therapeutic Function

Mucolytic

World Health Organization (WHO)

Mesna, an antidote used to protect patients treated with cyclophosphamide or ifosfamide from haemorrhagic vesiculitis, was introduced on the market in 1984. Shortly afterwards, its use became associated with allergic reactions, which occurred mainly in patients treated with the oral solution. This led to the withdrawal of this formulation in Germany, the only country where it was marketed. An oral liquid dosage form is still registered, but not marketed, in the Netherlands and products for intravenous injection remain available elsewhere.

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Contact allergens

Mesna is used as a mucolytic agent, and as an antidote to chloro-acetyl-aldehyde and acrolein (a bladder toxic metabolite of ifosfamide or cyclophosphamide). It hasbeen reported as a cause of occupational allergic (hand and airborne) dermatitis in nurses

Clinical Use

Prophylaxis of urothelial toxicity in patients treated with ifosfamide or cyclophosphamide

Metabolism

Rapidly metabolised in the liver to the disulfide, dimesna, and is excreted in the urine as both metabolite and unchanged drug; dimesna is reduced back to mesna, which is the active form, in the kidney.

Purification Methods

It can be recrystallised from H2O and does not melt below 250o. It is purified further by converting to the free acid by passing a 2M solution through an ion-exchange (Amberlite IR-120) column in the acid form, evaporating the eluate in a vacuum to give the acid as a viscous oil (readily decomposes) which can be checked by acid and SH titration. It is then dissolved in H2O, carefully neutralised with aqueous NaOH, evaporated and the salt recrystallised from H2O [Schramm J Am Chem Soc 77 6231 1955]. [Beilstein 4 IV 85.]

Mesna Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Mesna Suppliers

Americas 1 Belgium 1 Brazil 3 Canada 3 China 311 Europe 4 France 1 Germany 9 India 39 Japan 4 Nepal 1 South Korea 1 Switzerland 1 United Kingdom 19 United States 46 Venezuela 1 Global 445

TCI Chemicals (India) Pvt. Ltd.

Tel: --
Fax: --
Email: sales-in@tcichemicals.com
Country: India
ProdList: 6768
Advantage: 58

CLEANCHEM LABORATORIES LLP

Tel: --
Fax: --
Email: sales4@cleanchemlab.com
Country: India
ProdList: 325
Advantage: 58

Aarti Healthcare Limited

Tel: --
Fax: --
Country: India
ProdList: 28
Advantage: 58

Mesha Pharma Private Limited

Tel: --
Fax: --
Country: India
ProdList: 133
Advantage: 58

RA CHEM PHARMA LTD

Tel: --
Fax: --
Email: info@rachempharma.com
Country: India
ProdList: 37
Advantage: 58

Shivam Pharma Chemicals

Tel: --
Fax: --
Email: info@shivampharma.com
Country: India
ProdList: 656
Advantage: 58

Cip Global (India)

Tel: --
Fax: --
Country: India
ProdList: 81
Advantage: 58

Mehta Medicare Private Limited

Tel: --
Fax: --
Country: India
ProdList: 8
Advantage: 58

Athos Chemicals

Tel: --
Fax: --
Email: export@athoschemicals.com
Country: India
ProdList: 315
Advantage: 58

Ruskin Chemipharm.

Tel: --
Fax: --
Email: sourcing@ruskinchemipharm.in
Country: India
ProdList: 16
Advantage: 58

Manus Aktteva Biopharma LLP

Tel: --
Fax: --
Country: India
ProdList: 655
Advantage: 58

Sequent Scientific Limited (Alivira Animal Health)

Tel: --
Fax: --
Email: Indranil.Chowdhury@alivira.in
Country: India
ProdList: 3
Advantage: 58

Aadivighnesh Chem Private Ltd.

Tel: --
Fax: --
Email: sales@aadivighnesh.com
Country: India
ProdList: 119
Advantage: 58

KPS Chemicals & Pharmaceuticals

Tel: --
Fax: --
Email: kpschempharma@gmail.com
Country: India
ProdList: 240
Advantage: 58

Disha APIs Pvt Ltd

Tel: --
Fax: --
Email: info@dishaapis.com
Country: India
ProdList: 90
Advantage: 58

Batavia Exports International

Tel: --
Fax: --
Country: India
ProdList: 43
Advantage: 58

Ayon PharmaChem

Tel: --
Fax: --
Email: bhargav@ayonpharmachem.com
Country: India
ProdList: 303
Advantage: 58

Clearsynth Labs

Tel: --
Fax: --
Email: fo@clearsynth.com
Country: India
ProdList: 3887
Advantage: 58

Monarch Pharmachem

Tel: --
Fax: --
Email: info@monarchpharmachem.com
Country: India
ProdList: 52
Advantage: 58

Pharma Affiliates

Tel: --
Fax: --
Email: @pharmaffiliates.com
Country: India
ProdList: 6754
Advantage: 58

Ralington Pharma

Tel: --
Fax: --
Email: info@ralingtonpharma.com
Country: India
ProdList: 312
Advantage: 58

Innovative Synthetic Molecules

Tel: --
Fax: --
Country: India
ProdList: 526
Advantage: 58

SOLARA ACTIVE PHARMA SCIENCES LTD

Tel: --
Fax: --
Email: info@solara.co.in
Country: India
ProdList: 89
Advantage: 58

AARTI INDUSTRIES LIMITED

Tel: --
Fax: --
Email: info@aarti-industries.com
Country: India
ProdList: 172
Advantage: 58

SynZeal Research Pvt Ltd

Tel: --
Fax: --
Email: standards@synzeal.com
Country: India
ProdList: 6514
Advantage: 58

Indogulf Group

Tel: --
Fax: --
Email: info@indogulfgroup.com
Country: India
ProdList: 249
Advantage: 58

Molecraft LifeSciences Pvt Ltd

Tel: --
Fax: --
Email: info@molecraft.com
Country: India
ProdList: 757
Advantage: 0

Cygnus Healthcare Specialities P Ltd

Tel: --
Fax: --
Country: India
ProdList: 3
Advantage: 58

Pharmaffiliates Analytics and Synthetics P. Ltd

Tel: --
Fax: --
Email: mktg@pharmaffiliates.com
Country: India
ProdList: 6739
Advantage: 58

A.J Chemicals

Tel: --
Fax: --
Email: sales@ajchem.in
Country: India
ProdList: 6100
Advantage: 58

SOLARA ACTIVE PHARMA SCIENCES LIMITED

Tel: --
Fax: --
Email: Investors@solara.co.in
Country: India
ProdList: 16
Advantage: 58

AARTI INDUSTRIES LTD

Tel: --
Fax: --
Email: info@aarti-industries.com
Country: India
ProdList: 32
Advantage: 58

Manus Aktteva

Tel: --
Fax: --
Email: info@manusaktteva.in
Country: India
ProdList: 581
Advantage: 34

dkpharmachem

Tel: --
Fax: --
Email: sales@dkpharmachem.com
Country: India
ProdList: 60
Advantage: 46

D.K. Pharma Chem Pvt. Ltd.

Tel: --
Fax: --
Country: India
ProdList: 12
Advantage: 51

More

Less

View Lastest Price from Mesna manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Mesna 19767-45-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 100kg
Release date: 2022-09-29

Hebei Weibang Biotechnology Co., Ltd

Product: Mesna 19767-45-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-18

Zibo Wei Bin Import & Export Trade Co. Ltd.

Product: Mesna 19767-45-4
Price: US $100.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10
Release date: 2023-07-11

19767-45-4, MesnaRelated Search:

Sodium hydroxide Sodium bicarbonate Diclofenac sodium Sodium ethylenesulphonate Sodium chloride Sodium isethionate Sodium sulfate Sodium benzoate Antirust agent T702 Sodium chlorite 2-METHYL-2-PROPENE-1-SULFONIC ACID SODIUM SALT Sodium acetate 2,7-Naphthalenedisulfonic acid disodium salt Sodium lignosulfonate 2-Ethylphenylhydrazine hydrochloride 1-DODECANESULFONIC ACID SODIUM SALT Trisodium phosphate 2-S-thiuronium ethanesulfonate

2-mercaptoethanesulfonic

2-mercaptoethanesulfonicacidmonosodiumsalt

MERCAPTOETHANESULFONIC ACID SODIUM SALT

MESNA SODIUM SALT

mesnaum

MESNEX

MESNA

COENZYME M

COENZYME M SODIUM SALT

HS-COM NA

2-MERCAPTOETHANESULFONIC ACID SODIUM

2-MERCAPTOETHANESULFONIC ACID SODIUM SALT

2-MERCAPTOETHANESULPHONIC ACID SODIUM SALT

SODIUM 2-MERCAPTOETHANESULFONATE

MesnaEp5

Sodium mercaptoethanesulfonate

Mesna(FDA)

2-MERCAPTOETHANESULFONIC ACID SODIUM SALT 95+%

Ethanesulfonic acid, 2-mercapto-, monosodium salt

MESNA(2-MERCAPTOETHANESULFONICACIDSODIUMSALT)

BETA-MERCAPTOETHANESULPHONICACIDSODIUMSALT

SODIUMMERCAPTOETHANESULPHONATE

SODIUM2-MERCAPTOETHANESULPHONATE

2-MERCAPTOETHANESULPHONATE,SODIUMSALT

2-MERCAPTOETHANESULFONIC ACID SODIUM SALT EP5

Mesna(sodium 2-mercaptoethanesulfonate)

2-Mercapto-1-ethanesulfonic Acid Monosodium Salt

Mesna:Sodium 2-mercaptoethanesulphonate

2-mercapto-ethanesulfonicacimonosodiumsalt

mesnum

mistabron

mitexan

mucofluid

uromitexan

D 7093

Mistabronco

UCB 3983

2-Mercaptoethanesulfonic acid sodium salt, Coenzyme M sodium salt, HS-CoM Na, MESNA

2- Mercaptothanesulfonic Acid Sodium Salt

MESNA (2-Mercaptoethanesulfonate sodiuM)

Mesna (200 mg)

sodiuM 1-sulfanyl-2-sulfoethyliuM

2-(acetylthio)ethanesulfonic acid

2-Mercaptoethanesulfonic-d4-acid sodiuM salt (MESNA-d4)

Mesna(UroMitexan, Mesnex)

Mesna API

2-Mercaptoethanesulfonic Acid Sodium Salt Mesna

SODIUM 2-MERCAPTOETHANESULFONATE FOR SYN

SodiuM 2-Mercaptoethanesulfonate (Mesna)

2-Mercaptoethanesulfonic,Mesna

Sodium2-Mercaptoethanesulfonate&gt

2-mercaptoethanesulphonate

Ethanesulfonic acid, 2-mercapto-, sodium salt (1:1)

Mesna USP/EP/BP

Mesna (1392807)

The department of sodium

Mesna Powder USP Standard

Mesina