5-HYDROXY-2-METHOXYPYRIDINE
- Product Name
- 5-HYDROXY-2-METHOXYPYRIDINE
- CAS No.
- 51834-97-0
- Chemical Name
- 5-HYDROXY-2-METHOXYPYRIDINE
- Synonyms
- Aficamten Impurity 9;6-Methoxy-3-pyridinol;6-methoxypyridin-3-ol;3-Pyridinol, 6-methoxy-;Pyronoprene Impurity 48;5-HYDROXY-2-METHOXYPYRIDIN;6-METHOXY-HYDROXY-PYRIDINE;5-hydroxy-2-methoxypridine;3-Pyridinol,6-methoxy-(9CI);5-HYDROXY-2-METHOXYPYRIDINE
- CBNumber
- CB7281013
- Molecular Formula
- C6H7NO2
- Formula Weight
- 125.13
- MOL File
- 51834-97-0.mol
5-HYDROXY-2-METHOXYPYRIDINE Property
- Melting point:
- 81 °C
- Boiling point:
- 330.1±22.0 °C(Predicted)
- Density
- 1.190±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- crystalline powder
- pka
- 9.69±0.10(Predicted)
- color
- Lemony beige
- InChI
- InChI=1S/C6H7NO2/c1-9-6-3-2-5(8)4-7-6/h2-4,8H,1H3
- InChIKey
- LKBKDKVMHWPZDB-UHFFFAOYSA-N
- SMILES
- C1=NC(OC)=CC=C1O
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H805290
- Product name
- 5-Hydroxy-2-methoxypyridine
- Packaging
- 500mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- H805290
- Product name
- 5-Hydroxy-2-methoxypyridine
- Packaging
- 1g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- H805290
- Product name
- 5-Hydroxy-2-methoxypyridine
- Packaging
- 10g
- Price
- $395
- Updated
- 2021/12/16
- Product number
- M13568
- Product name
- 2-Methoxy-5-hydroxypyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $25
- Updated
- 2021/12/16
- Product number
- 6660-1-U6
- Product name
- 5-Hydroxy-2-methoxypyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
5-HYDROXY-2-METHOXYPYRIDINE Chemical Properties,Usage,Production
Uses
5-Hydroxy-2-methoxypyridine, is a heterocyclic building block used in various chemical synthesis.
Synthesis
13472-85-0
51834-97-0
Step 2. Synthesis of 5-hydroxy-2-methoxypyridine: To a stirred solution of 5-bromo-2-methoxypyridine (8.9 g, 47.9 mmol) in tetrahydrofuran (THF, 175 mL) was added slowly and dropwise to a solution of n-butyllithium (2.5 M hexane solution, 28.7 mL, 71.8 mmol) at -78 °C. The reaction was continued for 45 min with stirring. The reaction mixture was stirred continuously at -78 °C for 45 min. Subsequently, trimethyl borate (7.06 mL, 62.2 mmol) was added via syringe and the mixture continued to be stirred at the same temperature for 2 hours. The reaction mixture was warmed up to 0 °C and treated by adding a mixture of 3N NaOH solution (25 mL, 71.77 mmol) and 30% hydrogen peroxide solution (~50 mL). The reaction mixture gradually turned yellow and slightly turbid and was then warmed to room temperature, held for 30 minutes and then heated to reflux temperature and maintained for 1 hour. After completion of the reaction, the mixture was cooled to room temperature. The aqueous layer was neutralized with 1N HCl solution and subsequently extracted with ether (Et2O, 2 x 100 mL). The organic layers were combined, dried with anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give a yellow viscous oily product (3.5 g, 60% yield).
References
[1] Medicinal Chemistry Research, 2013, vol. 22, # 4, p. 1825 - 1836
[2] Heterocycles, 2002, vol. 57, # 1, p. 55 - 71
[3] Patent: EP1449834, 2004, A2. Location in patent: Page 27
[4] Patent: EP1042305, 2005, B1. Location in patent: Page/Page column 33
[5] Patent: US2003/207914, 2003, A1. Location in patent: Page/Page column 12
5-HYDROXY-2-METHOXYPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
5-HYDROXY-2-METHOXYPYRIDINE Suppliers
- Tel
- --
- Fax
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- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
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View Lastest Price from 5-HYDROXY-2-METHOXYPYRIDINE manufacturers
- Product
- 6-Methoxy-3-pyridinol 51834-97-0
- Price
- US $1.10-9.90/KG
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 100KG
- Release date
- 2025-08-20
- Product
- 5-Hydroxy-2-methoxypyridine 51834-97-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-14
- Product
- 5-HYDROXY-2-METHOXYPYRIDINE 51834-97-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-09-24