5-Methoxy-2,4-pyrimidinediol
- Product Name
- 5-Methoxy-2,4-pyrimidinediol
- CAS No.
- 6623-81-0
- Chemical Name
- 5-Methoxy-2,4-pyrimidinediol
- Synonyms
- mo5Ura;NSC 55452;5-METHOXYURACIL;4-pyrimidinediol;Fluorouracil Impurity D;Fluorouracil EP ImpurityD;Fluorouracil BP Impurity D;5-METHOXYPYRIMIDINE-2,4-DIOL;5-Methoxy-2,4-pyrimidinediol;5-Methoxypyrimidine-2,4-dione
- CBNumber
- CB1451247
- Molecular Formula
- C5H6N2O3
- Formula Weight
- 142.11
- MOL File
- 6623-81-0.mol
5-Methoxy-2,4-pyrimidinediol Property
- Melting point:
- 344°C(lit.)
- Density
- 1.39±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly, Heated), Water (Slightly, Heated)
- pka
- 8.17±0.10(Predicted)
- form
- Solid
- color
- White to Off-White
- InChI
- InChI=1S/C5H6N2O3/c1-10-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9)
- InChIKey
- KELXHQACBIUYSE-UHFFFAOYSA-N
- SMILES
- C1(=O)NC=C(OC)C(=O)N1
- CAS DataBase Reference
- 6623-81-0(CAS DataBase Reference)
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D4599
- Product name
- 2,4-Dihydroxy-5-methoxypyrimidine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $72
- Updated
- 2025/07/31
- Product number
- D4599
- Product name
- 2,4-Dihydroxy-5-methoxypyrimidine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $218
- Updated
- 2025/07/31
- Product number
- M271750
- Product name
- 5-Methoxyuracil
- Packaging
- 2g
- Price
- $135
- Updated
- 2021/12/16
- Product number
- 016446
- Product name
- 5-Methoxyuracil
- Packaging
- 2.5g
- Price
- $446
- Updated
- 2021/12/16
- Product number
- NUC0000385
- Product name
- 5-METHOXYURACIL
- Purity
- 95.00%
- Packaging
- 500MG
- Price
- $475
- Updated
- 2021/12/16
5-Methoxy-2,4-pyrimidinediol Chemical Properties,Usage,Production
Chemical Properties
Beige powder
Uses
5-Methoxyuracil (Fluorouracil EP Impurity D) is methoxylated uracil, a component of nucleid acid. 5-Methoxyuracil is used in the preparation of nucleosides.
Uses
5-Methoxy-2,4-pyrimidinediol is used as building block in chemical synthesis, it is also used in the preparation of nucleosides.
Uses
5-Methoxyuracil is methoxylated uracil, a component of nucleid acid. 5-Methoxyuracil is used in the preparation of nucleosides.
Synthesis
6939-11-3
6623-81-0
A reflux reaction was carried out for 2 hours using 5-methoxy-2-thio-2,3-dihydropyrimidin-4(1H)-one (21.5 g, 0.137 mol) as starting material, mixed with chloroacetic acid (21.5 g, 0.227 mol) in water (585 mL). Subsequently, concentrated hydrochloric acid (85 mL) was added to the reaction system and the reflux reaction was continued for 16 hours. Upon completion of the reaction, the reaction mixture was cooled to room temperature and the solid product was precipitated. The solid was collected by filtration, washed with water and dried to afford 5-methoxy-2,4-dihydroxypyrimidine (18.2 g, 94% yield). Mass spectrometry analysis showed (M + H)+ = 143.
References
[1] Patent: US2008/182852, 2008, A1. Location in patent: Page/Page column 15
5-Methoxy-2,4-pyrimidinediol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Methoxy-2,4-pyrimidinediol manufacturers
- Product
- 5-Methoxy-2,4-pyrimidinediol 6623-81-0
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- HPLC 98.0%
- Supply Ability
- 20tons
- Release date
- 2023-09-08
- Product
- 5-Methoxy-2,4-pyrimidinediol 6623-81-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-09
- Product
- 5-Methoxy-2,4-pyrimidinediol 6623-81-0
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-15