ChemicalBook > CAS DataBase List > 5-Methoxy-2,4-pyrimidinediol

5-Methoxy-2,4-pyrimidinediol

Product Name: 5-Methoxy-2,4-pyrimidinediol
CAS No.: 6623-81-0
Chemical Name: 5-Methoxy-2,4-pyrimidinediol
Synonyms: mo5Ura;NSC 55452;5-METHOXYURACIL;4-pyrimidinediol;Fluorouracil Impurity D;Fluorouracil EP ImpurityD;Fluorouracil BP Impurity D;5-METHOXYPYRIMIDINE-2,4-DIOL;5-Methoxy-2,4-pyrimidinediol;5-Methoxypyrimidine-2,4-dione
CBNumber: CB1451247
Molecular Formula: C5H6N2O3
Formula Weight: 142.11
MOL File: 6623-81-0.mol

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5-Methoxy-2,4-pyrimidinediol Property

Melting point:: 344°C(lit.)
Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly, Heated), Water (Slightly, Heated)
pka: 8.17±0.10(Predicted)
form: Solid
color: White to Off-White
InChI: InChI=1S/C5H6N2O3/c1-10-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9)
InChIKey: KELXHQACBIUYSE-UHFFFAOYSA-N
SMILES: C1(=O)NC=C(OC)C(=O)N1
CAS DataBase Reference: 6623-81-0(CAS DataBase Reference)

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Safety

HazardClass: IRRITANT
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D4599
Product name: 2,4-Dihydroxy-5-methoxypyrimidine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $72
Updated: 2025/07/31

TCI Chemical

Product number: D4599
Product name: 2,4-Dihydroxy-5-methoxypyrimidine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $218
Updated: 2025/07/31

TRC

Product number: M271750
Product name: 5-Methoxyuracil
Packaging: 2g
Price: $135
Updated: 2021/12/16

Usbiological

Product number: 016446
Product name: 5-Methoxyuracil
Packaging: 2.5g
Price: $446
Updated: 2021/12/16

Matrix Scientific

Product number: 048276
Product name: 5-Methoxy-2,4-pyrimidinediol
Purity: >95%
Packaging: 1g
Price: $10
Updated: 2021/12/16

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5-Methoxy-2,4-pyrimidinediol Chemical Properties,Usage,Production

Chemical Properties

Beige powder

Uses

5-Methoxyuracil (Fluorouracil EP Impurity D) is methoxylated uracil, a component of nucleid acid. 5-Methoxyuracil is used in the preparation of nucleosides.

Uses

5-Methoxy-2,4-pyrimidinediol is used as building block in chemical synthesis, it is also used in the preparation of nucleosides.

Uses

5-Methoxyuracil is methoxylated uracil, a component of nucleid acid. 5-Methoxyuracil is used in the preparation of nucleosides.

Synthesis

6939-11-3

6623-81-0

A reflux reaction was carried out for 2 hours using 5-methoxy-2-thio-2,3-dihydropyrimidin-4(1H)-one (21.5 g, 0.137 mol) as starting material, mixed with chloroacetic acid (21.5 g, 0.227 mol) in water (585 mL). Subsequently, concentrated hydrochloric acid (85 mL) was added to the reaction system and the reflux reaction was continued for 16 hours. Upon completion of the reaction, the reaction mixture was cooled to room temperature and the solid product was precipitated. The solid was collected by filtration, washed with water and dried to afford 5-methoxy-2,4-dihydroxypyrimidine (18.2 g, 94% yield). Mass spectrometry analysis showed (M + H)+ = 143.

References

[1] Patent: US2008/182852, 2008, A1. Location in patent: Page/Page column 15

5-Methoxy-2,4-pyrimidinediol Preparation Products And Raw materials

Raw materials

Preparation Products

2,4-Dichloro-5-methoxypyrimidine

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View Lastest Price from 5-Methoxy-2,4-pyrimidinediol manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: 5-Methoxy-2,4-pyrimidinediol 6623-81-0
Price: US $1.00/kg
Min. Order: 1kg
Purity: HPLC 98.0%
Supply Ability: 20tons
Release date: 2023-09-08

Dideu Industries Group Limited

Product: 5-Methoxy-2,4-pyrimidinediol 6623-81-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-09

Career Henan Chemical Co

Product: 5-Methoxy-2,4-pyrimidinediol 6623-81-0
Price: US $8.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-15

6623-81-0, 5-Methoxy-2,4-pyrimidinediolRelated Search:

Thymine Anisole 4-Methoxyphenylacetone (Trifluoromethoxy)benzene Triclosan Chrysin Uracil p-Anisidine 1-Hydroxyethylidene-1,1-diphosphonic acid p-Anisaldehyde Pyrimidine, 5-methoxy- (6CI,7CI,8CI,9CI) 5-FLUORO-2-METHOXYURACIL 5-Methoxy-4,6-pyrimidinedio 3-[(4,6-DIMETHOXYPYRIMIDIN-2-YL)OXY]PYRIDINE-2-CARBOXYLIC ACID 2-[(4,6-DIMETHOXYPYRIMIDIN-2-YL)OXY]BENZOIC ACID METHYL 3-FORMYLINDOLE-6-CARBOXYLATE 6-METHOXYURACIL 5-Methoxy-2,4-pyrimidinediol

5-Methoxypyrimidine-2,4(1H,3H)-dione

mo5Ura

NSC 55452

3h)-pyrimidinedione,5-methoxy-4(1h

5-Methoxypyrimidine-2,4-dione

Fluorouracil EP ImpurityD

Fluorouracil Impurity 4（Fluorouracil EP Impurity D）

5-Methoxy-2,4-pyrimidinedione

5-methoxy-1,2,3,4-tetrahydropyrimidine-2,4-dione

2,4(1H,3H)-Pyrimidinedione, 5-methoxy- (9CI)

2,4-DIHYDROXY-5-METHOXYOPYRIMIDINE

5-Methoxy-1H-pyrimidine-2,4-dione

2,4-DIHYDROXY-5-METHOXYPYRIMIDINE

2,4(1H,3H)-PYRIMIDINEDIONE, 5-METHOXY-

5-METHOXY-2,4-DIHYDROXY PYRIMIDINE

5-METHOXYURACIL

5-METHOXYPYRIMIDINE-2,4-DIOL

5-METHOXYURACIL/2,4-DIHYDROXY-5-METHOXYPYRIMIDINE

5-Methoxy-2,4-pyrimidinediol

5-methoxy-2,4(1H,3H)-pyrimidinedione

Fluorouracil BP Impurity D

2,4-Dihydroxy-5-methoxypyrimidine &gt

5-Methoxy-2,4-pyrimidinediol ISO 9001：2015 REACH

4-pyrimidinediol

Fluorouracil EP Impurity D (5-Methoxyuracil)

Fluorouracil Impurity D

5-Methoxypyrimidine-2,4(1H,3H)-dione (5-Methoxyuracil)

2,4-Dihydroxy-5-methoxypyrimidine 98%

6623-81-0

Heterocycle-Pyrimidine series

various pyrimidines

Pyrimidines

PYRIMIDINE

APIs & Intermediate