ChemicalBook > CAS DataBase List > 5-Methoxy-2,4-pyrimidinediol

5-Methoxy-2,4-pyrimidinediol

Product Name
5-Methoxy-2,4-pyrimidinediol
CAS No.
6623-81-0
Chemical Name
5-Methoxy-2,4-pyrimidinediol
Synonyms
mo5Ura;NSC 55452;5-METHOXYURACIL;4-pyrimidinediol;Fluorouracil Impurity D;Fluorouracil EP ImpurityD;Fluorouracil BP Impurity D;5-METHOXYPYRIMIDINE-2,4-DIOL;5-Methoxy-2,4-pyrimidinediol;5-Methoxypyrimidine-2,4-dione
CBNumber
CB1451247
Molecular Formula
C5H6N2O3
Formula Weight
142.11
MOL File
6623-81-0.mol
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5-Methoxy-2,4-pyrimidinediol Property

Melting point:
344°C(lit.)
Density 
1.39±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly, Heated), Water (Slightly, Heated)
pka
8.17±0.10(Predicted)
form 
Solid
color 
White to Off-White
InChI
InChI=1S/C5H6N2O3/c1-10-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9)
InChIKey
KELXHQACBIUYSE-UHFFFAOYSA-N
SMILES
C1(=O)NC=C(OC)C(=O)N1
CAS DataBase Reference
6623-81-0(CAS DataBase Reference)
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Safety

HazardClass 
IRRITANT
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D4599
Product name
2,4-Dihydroxy-5-methoxypyrimidine
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$72
Updated
2025/07/31
TCI Chemical
Product number
D4599
Product name
2,4-Dihydroxy-5-methoxypyrimidine
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$218
Updated
2025/07/31
TRC
Product number
M271750
Product name
5-Methoxyuracil
Packaging
2g
Price
$135
Updated
2021/12/16
Usbiological
Product number
016446
Product name
5-Methoxyuracil
Packaging
2.5g
Price
$446
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
NUC0000385
Product name
5-METHOXYURACIL
Purity
95.00%
Packaging
500MG
Price
$475
Updated
2021/12/16
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5-Methoxy-2,4-pyrimidinediol Chemical Properties,Usage,Production

Chemical Properties

Beige powder

Uses

5-Methoxyuracil (Fluorouracil EP Impurity D) is methoxylated uracil, a component of nucleid acid. 5-Methoxyuracil is used in the preparation of nucleosides.

Uses

5-Methoxy-2,4-pyrimidinediol is used as building block in chemical synthesis, it is also used in the preparation of nucleosides.

Uses

5-Methoxyuracil is methoxylated uracil, a component of nucleid acid. 5-Methoxyuracil is used in the preparation of nucleosides.

Synthesis

6939-11-3

6623-81-0

A reflux reaction was carried out for 2 hours using 5-methoxy-2-thio-2,3-dihydropyrimidin-4(1H)-one (21.5 g, 0.137 mol) as starting material, mixed with chloroacetic acid (21.5 g, 0.227 mol) in water (585 mL). Subsequently, concentrated hydrochloric acid (85 mL) was added to the reaction system and the reflux reaction was continued for 16 hours. Upon completion of the reaction, the reaction mixture was cooled to room temperature and the solid product was precipitated. The solid was collected by filtration, washed with water and dried to afford 5-methoxy-2,4-dihydroxypyrimidine (18.2 g, 94% yield). Mass spectrometry analysis showed (M + H)+ = 143.

References

[1] Patent: US2008/182852, 2008, A1. Location in patent: Page/Page column 15

5-Methoxy-2,4-pyrimidinediol Preparation Products And Raw materials

Raw materials

Preparation Products

2,4-Dichloro-5-methoxypyrimidine
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5-Methoxy-2,4-pyrimidinediol Suppliers

Americas 1 Canada 1 China 232 Europe 4 Germany 4 India 10 Japan 2 Slovakia 1 Switzerland 1 The Netherlands 1 United Kingdom 11 United States 24 Global 292
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
Advantage
75
CHEMSTEP
Tel
--
Fax
--
Email
info@chemstep.com
Country
Europe
ProdList
6143
Advantage
51
ecochem international chemical broker
Tel
--
Fax
--
Email
export@ecochem.dk
Country
Europe
ProdList
6371
Advantage
66
kemikalieimport
Tel
--
Fax
--
Email
Sales@kemikalieimport.dk
Country
Europe
ProdList
6685
Advantage
47
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View Lastest Price from 5-Methoxy-2,4-pyrimidinediol manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
5-Methoxy-2,4-pyrimidinediol 6623-81-0
Price
US $1.00/kg
Min. Order
1kg
Purity
HPLC 98.0%
Supply Ability
20tons
Release date
2023-09-08
Dideu Industries Group Limited
Product
5-Methoxy-2,4-pyrimidinediol 6623-81-0
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-12-09
Career Henan Chemical Co
Product
5-Methoxy-2,4-pyrimidinediol 6623-81-0
Price
US $8.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100KG
Release date
2018-12-15

6623-81-0, 5-Methoxy-2,4-pyrimidinediolRelated Search:

Thymine Anisole 4-Methoxyphenylacetone (Trifluoromethoxy)benzene Triclosan Chrysin Uracil p-Anisidine 1-Hydroxyethylidene-1,1-diphosphonic acid p-Anisaldehyde Pyrimidine, 5-methoxy- (6CI,7CI,8CI,9CI) 5-FLUORO-2-METHOXYURACIL 5-Methoxy-4,6-pyrimidinedio 3-[(4,6-DIMETHOXYPYRIMIDIN-2-YL)OXY]PYRIDINE-2-CARBOXYLIC ACID 2-[(4,6-DIMETHOXYPYRIMIDIN-2-YL)OXY]BENZOIC ACID METHYL 3-FORMYLINDOLE-6-CARBOXYLATE 6-METHOXYURACIL 5-Methoxy-2,4-pyrimidinediol

  • 5-Methoxypyrimidine-2,4(1H,3H)-dione
  • mo5Ura
  • NSC 55452
  • 3h)-pyrimidinedione,5-methoxy-4(1h
  • 5-Methoxypyrimidine-2,4-dione
  • Fluorouracil EP ImpurityD
  • Fluorouracil Impurity 4（Fluorouracil EP Impurity D）
  • 5-Methoxy-2,4-pyrimidinedione
  • 5-methoxy-1,2,3,4-tetrahydropyrimidine-2,4-dione
  • 2,4(1H,3H)-Pyrimidinedione, 5-methoxy- (9CI)
  • 2,4-DIHYDROXY-5-METHOXYOPYRIMIDINE
  • 5-Methoxy-1H-pyrimidine-2,4-dione
  • 2,4-DIHYDROXY-5-METHOXYPYRIMIDINE
  • 2,4(1H,3H)-PYRIMIDINEDIONE, 5-METHOXY-
  • 5-METHOXY-2,4-DIHYDROXY PYRIMIDINE
  • 5-METHOXYURACIL
  • 5-METHOXYPYRIMIDINE-2,4-DIOL
  • 5-METHOXYURACIL/2,4-DIHYDROXY-5-METHOXYPYRIMIDINE
  • 5-Methoxy-2,4-pyrimidinediol
  • 5-methoxy-2,4(1H,3H)-pyrimidinedione
  • Fluorouracil BP Impurity D
  • 2,4-Dihydroxy-5-methoxypyrimidine &gt
  • 5-Methoxy-2,4-pyrimidinediol ISO 9001：2015 REACH
  • 4-pyrimidinediol
  • Fluorouracil EP Impurity D (5-Methoxyuracil)
  • Fluorouracil Impurity D
  • 5-Methoxypyrimidine-2,4(1H,3H)-dione (5-Methoxyuracil)
  • 2,4-Dihydroxy-5-methoxypyrimidine 98%
  • 6623-81-0
  • Heterocycle-Pyrimidine series
  • various pyrimidines
  • Pyrimidines
  • PYRIMIDINE
  • APIs & Intermediate