2,4-Dichloro-5-methoxypyrimidine

Product Name: 2,4-Dichloro-5-methoxypyrimidine
CAS No.: 19646-07-2
Chemical Name: 2,4-Dichloro-5-methoxypyrimidine
Synonyms: SPECS AO-324/25087002;Acrylamide Impurity 23;oro-5-methoxypyrimidine;4-Dichloro-5-Methoxy pyriMidine;2,4-Dichloro-5-methoxpyrimidine;2,4-Dichloro-5-methoxypyrimidine;2,4-AICHLORO-5-METHOXY PYRIMIDINE;5-METHOXY-2,4-DICHLORO PYRIMIDINE;2,4- twochloro -5-MethoxypyriMidine;2,4-Dichloro-5-methoxypyrimidine>
CBNumber: CB5316542
Molecular Formula: C5H4Cl2N2O
Formula Weight: 179
MOL File: 19646-07-2.mol

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2,4-Dichloro-5-methoxypyrimidine Property

Melting point:: 66-70 °C
Boiling point:: 259.9±20.0 °C(Predicted)
Density: 1.446±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
pka: -2.67±0.29(Predicted)
color: White to Almost white
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C5H4Cl2N2O/c1-10-3-2-8-5(7)9-4(3)6/h2H,1H3
InChIKey: ZTHHRSBDBPCCMZ-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C(OC)C(Cl)=N1
CAS DataBase Reference: 19646-07-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,C,Xn
Risk Statements: 22-37/38-41
Safety Statements: 26-39
WGK Germany: 3
Hazard Note: Harmful
HazardClass: IRRITANT, CORROSIVE
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 679089
Product name: 2,4-Dichloro-5-methoxypyrimidine
Purity: 97%
Packaging: 10g
Price: $83.68
Updated: 2025/07/31

Sigma-Aldrich

Product number: 679089
Product name: 2,4-Dichloro-5-methoxypyrimidine
Purity: 97%
Packaging: 1g
Price: $34.6
Updated: 2023/06/20

TCI Chemical

Product number: D3508
Product name: 2,4-Dichloro-5-methoxypyrimidine
Purity: >98.0%(GC)
Packaging: 5g
Price: $133
Updated: 2025/07/31

TCI Chemical

Product number: D3508
Product name: 2,4-Dichloro-5-methoxypyrimidine
Purity: >98.0%(GC)
Packaging: 25g
Price: $353
Updated: 2025/07/31

TRC

Product number: D435275
Product name: 2,4-Dichloro-5-methoxypyrimidine
Packaging: 25g
Price: $165
Updated: 2021/12/16

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2,4-Dichloro-5-methoxypyrimidine Chemical Properties,Usage,Production

Uses

It is used for preparation of heteroarylpiperazine derivatives for use in treatment of Alzheimer's disease.

Uses

2,4-Dichloro-5-methoxypyrimidine can be used for preparation of heteroarylpiperazine derivatives for use in treatment of Alzheimer's disease.

Synthesis

6623-81-0

19646-07-2

The general procedure for the synthesis of 2,4-dichloro-5-methoxypyrimidines from 5-methoxy-2,4-dihydroxypyrimidines was as follows: 5-methoxy-2,4-dihydroxypyrimidines (45 g, 0.316 mol), phosphorus trichloride (225 mL, 0.88 mol), and N,N-dimethylaniline (45 mL, 0.391 mol) were mixed, and the reaction was carried out at reflux for 2 hours. After completion of the reaction, the mixture was quenched by slowly pouring it into crushed ice (80 g). The product was extracted with ether and subsequently purified by recrystallization from light petroleum ether (boiling point: 40-60 °C) to afford 2,4-dichloro-5-methoxypyrimidine (43 g, 75% yield). Results of mass spectrometry analysis: (ES+) m/z 179 [M+H]+.

References

[1] Journal of Organic Chemistry, 2011, vol. 76, # 10, p. 4149 - 4153
[2] Patent: WO2011/144577, 2011, A1. Location in patent: Page/Page column 24
[3] Patent: WO2011/80568, 2011, A2. Location in patent: Page/Page column 109-110
[4] Patent: WO2011/144578, 2011, A1. Location in patent: Page/Page column 26; 27

2,4-Dichloro-5-methoxypyrimidine Preparation Products And Raw materials

Raw materials

5-Methoxy-2,4-pyrimidinediol Phosphorus oxitrichloride Urea Sodium Methoxide N,N-Dimethylaniline Diethyl ether Benzene Methyl methoxyacetate Methanol DIMETHYLANILINE Methyl formate PETROLEUM ETHER

Preparation Products

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2,4-Dichloro-5-methoxypyrimidine Suppliers

Americas 1 Austria 1 Belgium 1 Canada 4 China 294 Europe 3 France 3 Germany 5 India 10 Japan 2 Switzerland 3 The Netherlands 2 Ukraine 1 United Kingdom 17 United States 47 Global 394

Changzhou Chemscaler Pharmtech Co., Ltd.

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Email: chemscaler@yahoo.com.cn
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ProdList: 311
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Shandong Xingao Biomedicine Technology Co. LTD

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Advantage: 58

Jiangsu Zhongyuan Chemicals Co.,Ltd.

Tel: 0513-0513-84539538 13817775327
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ProdList: 33
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Wuhan Boye Technology Development Co., Ltd.

Tel: 027-81625225 15377010747
Fax: 027-81625225
Email: hui@boyechemicals.com
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Zhengzhou Ailfield Chemical Co., Ltd.

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Jiangxi Boye Medical Technology Co., Ltd

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Fax: 027-81625225
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Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
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J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
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Country: China
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Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
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View Lastest Price from 2,4-Dichloro-5-methoxypyrimidine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2,4-Dichloro-5-methoxypyrimidine 19646-07-2
Price: US $21.00/KG
Min. Order: 1KG
Purity: 99.0% min
Supply Ability: 100 tons
Release date: 2021-04-20

Shaanxi Dideu New Materials Co. Ltd

Product: 2,4-Dichloro-5-methoxypyrimidine 19646-07-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-26

Career Henan Chemical Co

Product: 2,4-Dichloro-5-methoxypyrimidine 19646-07-2
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: ask
Release date: 2018-12-22

19646-07-2, 2,4-Dichloro-5-methoxypyrimidineRelated Search:

Methoxydiethylborane 2,4-Dichloro-5-methylpyrimidine Anisole POLY(ETHYLENE GLYCOL) METHYL ETHER ACRYLATE 2,4-Dichloropyrimidine 4-Methoxybenzoic acid Methoxyacetic acid p-Anisaldehyde (Trifluoromethoxy)benzene p-Anisidine 2,4-Dichloro-5-fluoropyrimidine 2-Methoxy-4,6-dichloropyrimidine 2,4-Dichloro-6-methoxypyrimidine 4,6-DICHLORO-5-METHOXYPYRIMIDINE,4,6-DICHLORO-5-METHOXYPYRIMIDINE 99%,2,4-Dichloro-5-methoxypyrimidine 2-Chloro-5-hydroxypyrimidine 2-Chloro-5-methoxypyrimidine 2,4-Dichloro-5-methoxypyrimidine

2,4-Dichloro-5-methoxy-1,3-diazine, 2,4-Dichloropyrimidin-5-yl methyl ether

2,4- twochloro -5-MethoxypyriMidine

5-METHOXY-2,4-DICHLORO PYRIMIDINE

2,4-DICHLORO-5-METHOXYPYRIMIDINE, 98+%

2,4-Dichloro-5-methoxypyrimidine

2,4-AICHLORO-5-METHOXY PYRIMIDINE

2,4-Dichloro-5-methoxpyrimidine

5-Methoxy-2,4-Dichloropyrimidine pyrimidine

SPECS AO-324/25087002

oro-5-methoxypyrimidine

4-Dichloro-5-Methoxy pyriMidine

2,4-Dichloro-5-methoxypyrimidine&gt

Pyrimidine, 2,4-dichloro-5-methoxy-

2,4-Dichloro-5-methoxypyrimidine ISO 9001：2015 REACH

Acrylamide Impurity 23

2,4-dichloro-5-methoxypyrimidine, 98%min

19646-07-2

19646-97-2

C5H4Cl2N2O

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyrimidines

PyrimidinesHeterocyclic Building Blocks

Heterocycle-Pyrimidine series

APIs & Intermediate

Pyrimidine

Pyridines, Pyrimidines, Purines and Pteredines

Aromatics

Heterocycles

19646-07-2