ChemicalBook > CAS DataBase List > 2-Chloro-5-methoxypyrimidine

2-Chloro-5-methoxypyrimidine

Product Name
2-Chloro-5-methoxypyrimidine
CAS No.
22536-65-8
Chemical Name
2-Chloro-5-methoxypyrimidine
Synonyms
2-Chloro-5-methoxypyrimidine;PyriMidine,2-chloro-5-Methoxy-;2-Chloro-5-methoxypyrimidine >2-Chloro-5-MethoxypyriMidine 97%;2-CHLORO-5-(METHOXY-D3)PYRIMIDINE;2-Chloro-5-methoxypyrimidine, 97%,;Pyrimidine, 2-chloro-5-methoxy- (8CI,9CI);2-Chloro-5-methoxypyrimidine ISO 9001：2015 REACH
CBNumber
CB7972353
Molecular Formula
C5H5ClN2O
Formula Weight
144.56
MOL File
22536-65-8.mol
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2-Chloro-5-methoxypyrimidine Property

Melting point:
73-78℃
Boiling point:
268.8±13.0 °C(Predicted)
Density 
1.292±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
-1.26±0.22(Predicted)
color 
White to Almost white
InChI
InChI=1S/C5H5ClN2O/c1-9-4-2-7-5(6)8-3-4/h2-3H,1H3
InChIKey
RSUBGBZOMBTDTI-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=C(OC)C=N1
CAS DataBase Reference
22536-65-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
37/38-41
Safety Statements 
26-39
WGK Germany 
3
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
681288
Product name
2-Chloro-5-methoxypyrimidine
Purity
97%
Packaging
500mg
Price
$178
Updated
2023/06/20
TCI Chemical
Product number
C2693
Product name
2-Chloro-5-methoxypyrimidine
Purity
>98.0%(GC)
Packaging
1g
Price
$38
Updated
2025/07/31
TCI Chemical
Product number
C2693
Product name
2-Chloro-5-methoxypyrimidine
Purity
>98.0%(GC)
Packaging
5g
Price
$141
Updated
2025/07/31
TRC
Product number
C360415
Product name
2-Chloro-5-methoxypyrimidine
Packaging
1g
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC15415
Product name
2-Chloro-5-methoxypyrimidine
Packaging
1g
Price
$78.8
Updated
2021/12/16
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2-Chloro-5-methoxypyrimidine Chemical Properties,Usage,Production

Chemical Properties

off-white powder

Uses

2-Chloro-5-methoxypyrimidine is used in the regioselective synthesis of aminoimidazopyrimidines with triflic anhydride and pyridine bases

Synthesis

19646-07-2

22536-65-8

General procedure for the synthesis of 2-chloro-5-methoxypyrimidine from 2,4-dichloro-5-methoxypyrimidine: 1. 2,4-Dichloro-5-methoxypyrimidine (43 g, 0.24 mol), zinc powder (86 g, 1.32 mol), ethanol (200 mL), and water (200 mL) were mixed, heated to reflux, and the reaction was maintained for 4 hours. 2. After completion of the reaction, the reaction mixture was filtered while hot. 3. The filtrate was distilled under reduced pressure to remove ethanol. 4. 4. After cooling, the product was extracted with ether. 5. 5. The extract was recrystallized from light petroleum ether (boiling point: 40-60 °C) to give purified 2-chloro-5-methoxypyrimidine (20 g, 58% yield).

References

[1] Patent: WO2011/144577, 2011, A1. Location in patent: Page/Page column 24
[2] Patent: WO2011/144578, 2011, A1. Location in patent: Page/Page column 27

2-Chloro-5-methoxypyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-5-methoxypyrimidine Suppliers

Americas 1 Canada 2 China 194 Europe 2 India 4 Japan 1 Switzerland 1 United Kingdom 5 United States 17 Global 227
Liyang Kunlu biological technology co.,ltd
Tel
0519-87310015 13813530041
Fax
0519-87310015
Email
200601296@qq.com
Country
China
ProdList
323
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12000
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9883
Advantage
59
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View Lastest Price from 2-Chloro-5-methoxypyrimidine manufacturers

Jinan Ruitong Biotech Co., Ltd.
Product
2-Chloro-5-methoxypyrimidine 22536-65-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1
Release date
2025-08-27
Shaanxi Dideu Medichem Co. Ltd
Product
2-Chloro-5-methoxypyrimidine 22536-65-8
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-12
R&D Scientific Inc.
Product
2-Chloro-5-methoxypyrimidine 22536-65-8
Price
US $2390.00/Kg
Min. Order
1Kg
Purity
98
Supply Ability
500 Kg
Release date
2024-09-06

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