2-Chloro-5-(phenylmethoxy)-pyrimidine

Product Name: 2-Chloro-5-(phenylmethoxy)-pyrimidine
CAS No.: 138274-14-3
Chemical Name: 2-Chloro-5-(phenylmethoxy)-pyrimidine
Synonyms: 5-(benzyloxy)-2-chloropyrimidine;2-Chloro-5-(benzyloxy)-pyrimidine;2-chloro-5-(phenylmethoxy)-pyrimidine;Pyrimidine, 2-chloro-5-(phenylmethoxy)-;Benzenesulfonylchloride,9-(acetylamino)-;5-(benzyloxy)-2-chloropyrimidine138274-14-3;1,3-Dioxane-4,6-dione,2,2-dimethyl-7-phenyl-;2-Chloro-5-(phenylmethoxy)-pyrimidine ISO 9001：2015 REACH
CBNumber: CB4854942
Molecular Formula: C11H9ClN2O
Formula Weight: 220.65
MOL File: 138274-14-3.mol

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2-Chloro-5-(phenylmethoxy)-pyrimidine Property

Boiling point:: 387.0±17.0 °C(Predicted)
Density: 1.278±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: -1.28±0.22(Predicted)
Appearance: Off-white to light yellow Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: B130085
Product name: 5-(Benzyloxy)-2-chloropyrimidine
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB151021
Product name: 5-(Benzyloxy)-2-chloropyrimidine
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB151021
Product name: 5-(Benzyloxy)-2-chloropyrimidine
Packaging: 250mg
Price: $150
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB151021
Product name: 5-(Benzyloxy)-2-chloropyrimidine
Packaging: 500mg
Price: $260
Updated: 2021/12/16

AK Scientific

Product number: W3013
Product name: 5-(Benzyloxy)-2-chloropyrimidine
Packaging: 5g
Price: $304
Updated: 2021/12/16

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2-Chloro-5-(phenylmethoxy)-pyrimidine Chemical Properties,Usage,Production

Synthesis

100-39-0

4983-28-2

138274-14-3

Example 9: Synthesis of 2-chloro-5-(phenylmethoxy)pyrimidine (compound 31) Under the guidance of the reference reaction scheme, potassium carbonate (11.6 g, 84.3 mmol) was added to a 500 mL methanol solution containing 10 g of 2-chloro-5-hydroxypyrimidine (76.6 mmol), followed by benzyl bromide (10.1 mL, 84.3 mmol). The reaction mixture was stirred at room temperature for 14 hours. Upon completion of the reaction, water (300 mL) was added to terminate the reaction. Methanol was removed by evaporation and the remaining aqueous layer was extracted with chloroform. The combined chloroform layers were washed with brine, dried with anhydrous magnesium sulfate and filtered. After removal of the solvent, the product was purified by silica gel column chromatography using 100:1 chloroform:methanol as eluent to afford 15 g (89% yield) of 2-chloro-5-(phenylmethoxy)pyrimidine (31) as a white solid. 1H NMR (CDCl3) δ 8.27 (s, 2H), 7.37-7.30 (m, 5H), 5.09 (s, 2H).

References

[1] Chemical and Pharmaceutical Bulletin, 1991, vol. 39, # 9, p. 2288 - 2300
[2] Patent: US2014/235858, 2014, A1. Location in patent: Paragraph 0095
[3] Journal of Medicinal Chemistry, 2015, vol. 58, # 22, p. 8796 - 8805
[4] Patent: WO2011/147951, 2011, A1. Location in patent: Page/Page column 63

2-Chloro-5-(phenylmethoxy)-pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-5-(phenylmethoxy)-pyrimidine Suppliers

China 101 Germany 1 India 1 United Kingdom 2 United States 10 Global 115

JinYan Chemicals(ShangHai) Co.,Ltd.

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SynAsst Chemical.

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View Lastest Price from 2-Chloro-5-(phenylmethoxy)-pyrimidine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Chloro-5-(phenylmethoxy)-pyrimidine 138274-14-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-13

Career Henan Chemical Co

Product: 2-Chloro-5-(phenylmethoxy)-pyrimidine 138274-14-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200kgs
Release date: 2020-01-28

138274-14-3, 2-Chloro-5-(phenylmethoxy)-pyrimidineRelated Search:

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5-(benzyloxy)-2-chloropyrimidine138274-14-3

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2-Chloro-5-(phenylmethoxy)-pyrimidine ISO 9001：2015 REACH

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2-Chloro-5-(benzyloxy)-pyrimidine

138274-14-3

Heterocycle-Pyrimidine series