2-Bromo-4-chloroanisole
- Product Name
- 2-Bromo-4-chloroanisole
- CAS No.
- 60633-25-2
- Chemical Name
- 2-Bromo-4-chloroanisole
- Synonyms
- 2-Bromo-4-chloroanis;2-BROMO-4-CHLOROANISOLE;4-Chloro 2-BroMo Anisole;2-Bromo-4-chloroanisole >2-Bromo-4-chloroanisole,98%;2-BroMo-4-chloroanisole, 98% 25ML;2-BROMO-4-CHLORO-1-METHOXY-BENZENE;Benzene, 2- bromo- 4- chloro- 1- methoxy-;2-Bromo-4-chloro-1-methoxybenzene, 2-Bromo-4-chlorophenyl methyl ether
- CBNumber
- CB8380603
- Molecular Formula
- C7H6BrClO
- Formula Weight
- 221.48
- MOL File
- 60633-25-2.mol
2-Bromo-4-chloroanisole Property
- Melting point:
- 28.6-29.1°C
- Boiling point:
- 122/20mm
- Density
- 1.625
- vapor pressure
- 8.7Pa at 25℃
- refractive index
- 1.5850-1.5890
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- form
- Liquid
- Specific Gravity
- 1.61
- color
- Clear colorless to pale yellow
- CAS DataBase Reference
- 60633-25-2(CAS DataBase Reference)
- NIST Chemistry Reference
- 2-Bromo-4-chloroanisole(60633-25-2)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-51-22
- Safety Statements
- 24/25
- HazardClass
- IRRITANT
- HS Code
- 29093090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B3111
- Product name
- 2-Bromo-4-chloroanisole
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $20
- Updated
- 2025/07/31
- Product number
- B3111
- Product name
- 2-Bromo-4-chloroanisole
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $72
- Updated
- 2025/07/31
- Product number
- B681940
- Product name
- 2-Bromo-4-chloroanisole
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 001630
- Product name
- 2-Bromo-4-chloroanisole
- Purity
- 99%
- Packaging
- 100g
- Price
- $49
- Updated
- 2021/12/16
- Product number
- 2607-D-X2
- Product name
- 2-Bromo-4-chloroanisole
- Packaging
- 100g
- Price
- $56
- Updated
- 2021/12/16
2-Bromo-4-chloroanisole Chemical Properties,Usage,Production
Chemical Properties
Clear colorless to pale yellow liquid
Uses
2-Bromo-4-chloroanisole has been used as a reactant in the preparation of naphthyl phenyl ethers as nonnucleoside HIV-1 reverse transcriptase inhibitors.
Synthesis
695-96-5
74-88-4
60633-25-2
General procedure for the synthesis of 2-bromo-4-chloroanisole from 2-bromo-4-chlorophenol and iodomethane: In a 250 mL round-bottomed flask, 2-bromo-4-chlorophenol (16.94 g, 81.6 mmol, 1.0 eq.) was dissolved in acetone (160 mL), and iodomethane (6.10 mL, 98 mmol, 1.2 eq.), potassium carbonate (12 g), and water (4 mL). The reaction mixture was heated to reflux for 3 h. After cooling to room temperature, most of the volatiles were removed under reduced pressure. The residue was poured into water (140 mL) and extracted with ethyl acetate (3 x 150 mL). The organic phases were combined, washed with brine (1 x 100 mL), dried (K2CO3), filtered through a pad of diatomaceous earth and concentrated to give a clear oil. Purification by short-range distillation (80°-85 °C, 1 Torr) afforded 17.74 g (98% yield) of 2-bromo-4-chloroanisole as a clear liquid. 2-bromo-4-chloroanisole was characterized by NMR hydrogen spectroscopy (400 MHz, acetone-d6) with the following data: δ 7.53 (d, J = 2.5 Hz, 1H); 7.24 (dd, J = 9.7, 2.5 Hz. 1H); 6.81 (d, J = 9.7 Hz, 1H); 3.88 (s, 3H).
References
[1] Angewandte Chemie - International Edition, 2008, vol. 47, # 27, p. 5067 - 5070
[2] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 14, p. 4220 - 4226
[3] Angewandte Chemie - International Edition, 2014, vol. 53, # 25, p. 6443 - 6448
[4] Angew. Chem., 2014, vol. 126, # 25, p. 6561 - 6566
[5] Patent: US5688808, 1997, A
2-Bromo-4-chloroanisole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Bromo-4-chloroanisole manufacturers
- Product
- 2-Bromo-4-chloroanisole 60633-25-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 2-Bromo-4-chloroanisole 60633-25-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-05-24