ChemicalBook > CAS DataBase List > 2-Bromo-4-chloroanisole

2-Bromo-4-chloroanisole

Product Name
2-Bromo-4-chloroanisole
CAS No.
60633-25-2
Chemical Name
2-Bromo-4-chloroanisole
Synonyms
2-Bromo-4-chloroanis;2-BROMO-4-CHLOROANISOLE;4-Chloro 2-BroMo Anisole;2-Bromo-4-chloroanisole >2-Bromo-4-chloroanisole,98%;2-BroMo-4-chloroanisole, 98% 25ML;2-BROMO-4-CHLORO-1-METHOXY-BENZENE;Benzene, 2- bromo- 4- chloro- 1- methoxy-;2-Bromo-4-chloro-1-methoxybenzene, 2-Bromo-4-chlorophenyl methyl ether
CBNumber
CB8380603
Molecular Formula
C7H6BrClO
Formula Weight
221.48
MOL File
60633-25-2.mol
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2-Bromo-4-chloroanisole Property

Melting point:
28.6-29.1°C
Boiling point:
122/20mm
Density 
1.625
vapor pressure 
8.7Pa at 25℃
refractive index 
1.5850-1.5890
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly)
form 
Liquid
Specific Gravity
1.61
color 
Clear colorless to pale yellow
CAS DataBase Reference
60633-25-2(CAS DataBase Reference)
NIST Chemistry Reference
2-Bromo-4-chloroanisole(60633-25-2)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-51-22
Safety Statements 
24/25
HazardClass 
IRRITANT
HS Code 
29093090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B3111
Product name
2-Bromo-4-chloroanisole
Purity
>98.0%(GC)
Packaging
5g
Price
$20
Updated
2025/07/31
TCI Chemical
Product number
B3111
Product name
2-Bromo-4-chloroanisole
Purity
>98.0%(GC)
Packaging
25g
Price
$72
Updated
2025/07/31
TRC
Product number
B681940
Product name
2-Bromo-4-chloroanisole
Packaging
1g
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
001630
Product name
2-Bromo-4-chloroanisole
Purity
99%
Packaging
25g
Price
$14
Updated
2021/12/16
AK Scientific
Product number
J54081
Product name
2-Bromo-4-chloroanisole
Packaging
5g
Price
$15
Updated
2021/12/16
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2-Bromo-4-chloroanisole Chemical Properties,Usage,Production

Chemical Properties

Clear colorless to pale yellow liquid

Uses

2-Bromo-4-chloroanisole has been used as a reactant in the preparation of naphthyl phenyl ethers as nonnucleoside HIV-1 reverse transcriptase inhibitors.

Synthesis

695-96-5

74-88-4

60633-25-2

General procedure for the synthesis of 2-bromo-4-chloroanisole from 2-bromo-4-chlorophenol and iodomethane: In a 250 mL round-bottomed flask, 2-bromo-4-chlorophenol (16.94 g, 81.6 mmol, 1.0 eq.) was dissolved in acetone (160 mL), and iodomethane (6.10 mL, 98 mmol, 1.2 eq.), potassium carbonate (12 g), and water (4 mL). The reaction mixture was heated to reflux for 3 h. After cooling to room temperature, most of the volatiles were removed under reduced pressure. The residue was poured into water (140 mL) and extracted with ethyl acetate (3 x 150 mL). The organic phases were combined, washed with brine (1 x 100 mL), dried (K2CO3), filtered through a pad of diatomaceous earth and concentrated to give a clear oil. Purification by short-range distillation (80°-85 °C, 1 Torr) afforded 17.74 g (98% yield) of 2-bromo-4-chloroanisole as a clear liquid. 2-bromo-4-chloroanisole was characterized by NMR hydrogen spectroscopy (400 MHz, acetone-d6) with the following data: δ 7.53 (d, J = 2.5 Hz, 1H); 7.24 (dd, J = 9.7, 2.5 Hz. 1H); 6.81 (d, J = 9.7 Hz, 1H); 3.88 (s, 3H).

References

[1] Angewandte Chemie - International Edition, 2008, vol. 47, # 27, p. 5067 - 5070
[2] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 14, p. 4220 - 4226
[3] Angewandte Chemie - International Edition, 2014, vol. 53, # 25, p. 6443 - 6448
[4] Angew. Chem., 2014, vol. 126, # 25, p. 6561 - 6566
[5] Patent: US5688808, 1997, A

2-Bromo-4-chloroanisole Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Bromo-4-chloroanisole manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
2-Bromo-4-chloroanisole 60633-25-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
2-Bromo-4-chloroanisole 60633-25-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2019-05-24

60633-25-2, 2-Bromo-4-chloroanisoleRelated Search:

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  • 2-BroMo-4-chloroanisole, 98% 25ML
  • 2-Bromo-4-chloroanisole,98%
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  • 2-Bromo-4-chloroanisole &gt
  • 60633-25-2
  • C7H6OBrCl
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  • Bromine Compounds
  • Chlorine Compounds