ChemicalBook > CAS DataBase List > 2-Chloro-5-(phenylmethoxy)-pyrimidine

2-Chloro-5-(phenylmethoxy)-pyrimidine

Product Name
2-Chloro-5-(phenylmethoxy)-pyrimidine
CAS No.
138274-14-3
Chemical Name
2-Chloro-5-(phenylmethoxy)-pyrimidine
Synonyms
5-(benzyloxy)-2-chloropyrimidine;2-Chloro-5-(benzyloxy)-pyrimidine;2-chloro-5-(phenylmethoxy)-pyrimidine;Pyrimidine, 2-chloro-5-(phenylmethoxy)-;Benzenesulfonylchloride,9-(acetylamino)-;5-(benzyloxy)-2-chloropyrimidine138274-14-3;1,3-Dioxane-4,6-dione,2,2-dimethyl-7-phenyl-;2-Chloro-5-(phenylmethoxy)-pyrimidine ISO 9001:2015 REACH
CBNumber
CB4854942
Molecular Formula
C11H9ClN2O
Formula Weight
220.65
MOL File
138274-14-3.mol
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2-Chloro-5-(phenylmethoxy)-pyrimidine Property

Boiling point:
387.0±17.0 °C(Predicted)
Density 
1.278±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
pka
-1.28±0.22(Predicted)
Appearance
Off-white to light yellow Solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
B130085
Product name
5-(Benzyloxy)-2-chloropyrimidine
Packaging
100mg
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB151021
Product name
5-(Benzyloxy)-2-chloropyrimidine
Packaging
100mg
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB151021
Product name
5-(Benzyloxy)-2-chloropyrimidine
Packaging
250mg
Price
$150
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB151021
Product name
5-(Benzyloxy)-2-chloropyrimidine
Packaging
500mg
Price
$260
Updated
2021/12/16
AK Scientific
Product number
W3013
Product name
5-(Benzyloxy)-2-chloropyrimidine
Packaging
5g
Price
$304
Updated
2021/12/16
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2-Chloro-5-(phenylmethoxy)-pyrimidine Chemical Properties,Usage,Production

Synthesis

100-39-0

4983-28-2

138274-14-3

Example 9: Synthesis of 2-chloro-5-(phenylmethoxy)pyrimidine (compound 31) Under the guidance of the reference reaction scheme, potassium carbonate (11.6 g, 84.3 mmol) was added to a 500 mL methanol solution containing 10 g of 2-chloro-5-hydroxypyrimidine (76.6 mmol), followed by benzyl bromide (10.1 mL, 84.3 mmol). The reaction mixture was stirred at room temperature for 14 hours. Upon completion of the reaction, water (300 mL) was added to terminate the reaction. Methanol was removed by evaporation and the remaining aqueous layer was extracted with chloroform. The combined chloroform layers were washed with brine, dried with anhydrous magnesium sulfate and filtered. After removal of the solvent, the product was purified by silica gel column chromatography using 100:1 chloroform:methanol as eluent to afford 15 g (89% yield) of 2-chloro-5-(phenylmethoxy)pyrimidine (31) as a white solid. 1H NMR (CDCl3) δ 8.27 (s, 2H), 7.37-7.30 (m, 5H), 5.09 (s, 2H).

References

[1] Chemical and Pharmaceutical Bulletin, 1991, vol. 39, # 9, p. 2288 - 2300
[2] Patent: US2014/235858, 2014, A1. Location in patent: Paragraph 0095
[3] Journal of Medicinal Chemistry, 2015, vol. 58, # 22, p. 8796 - 8805
[4] Patent: WO2011/147951, 2011, A1. Location in patent: Page/Page column 63

2-Chloro-5-(phenylmethoxy)-pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Chloro-5-(phenylmethoxy)-pyrimidine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-Chloro-5-(phenylmethoxy)-pyrimidine 138274-14-3
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-13
Career Henan Chemical Co
Product
2-Chloro-5-(phenylmethoxy)-pyrimidine 138274-14-3
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200kgs
Release date
2020-01-28

138274-14-3, 2-Chloro-5-(phenylmethoxy)-pyrimidineRelated Search:


  • 2-chloro-5-(phenylmethoxy)-pyrimidine
  • 5-(benzyloxy)-2-chloropyrimidine
  • 5-(benzyloxy)-2-chloropyrimidine138274-14-3
  • Pyrimidine, 2-chloro-5-(phenylmethoxy)-
  • 2-Chloro-5-(phenylmethoxy)-pyrimidine ISO 9001:2015 REACH
  • 1,3-Dioxane-4,6-dione,2,2-dimethyl-7-phenyl-
  • Benzenesulfonylchloride,9-(acetylamino)-
  • 2-Chloro-5-(benzyloxy)-pyrimidine
  • 138274-14-3
  • Heterocycle-Pyrimidine series