4-Amino-6-chloro-5-methoxypyrimidine
- Product Name
- 4-Amino-6-chloro-5-methoxypyrimidine
- CAS No.
- 5018-41-7
- Chemical Name
- 4-Amino-6-chloro-5-methoxypyrimidine
- Synonyms
- 6-CHLORO-5-METHOXYPYRIMIDIN-4-AMINE;6-Chloro-5-methoxy-4-pyrimidinamine;4-Amino-6-Chloro-5-Methoxy Pyrimidin;4-AMINO-6-CHLORO-5-METHOXYPYRIMIDINE;6-Chloro-5-MethoxypyriMidin-4-ylaMine;4-Pyrimidinamine, 6-chloro-5-methoxy-;4-Amino-6-chloro-5-methoxypyrimidine ISO 9001：2015 REACH;4-(p-AMinobenzene SulfonaMino)-5Methoxy-6-Chloro PyriMidine)
- CBNumber
- CB8433466
- Molecular Formula
- C5H6ClN3O
- Formula Weight
- 159.57
- MOL File
- 5018-41-7.mol
4-Amino-6-chloro-5-methoxypyrimidine Property
- Melting point:
- 176-178 °C
- Boiling point:
- 305.4±37.0 °C(Predicted)
- Density
- 1.398±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 1.51±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C5H6ClN3O/c1-10-3-4(6)8-2-9-5(3)7/h2H,1H3,(H2,7,8,9)
- InChIKey
- AAJZJNHQPBMCFV-UHFFFAOYSA-N
- SMILES
- C1=NC(Cl)=C(OC)C(N)=N1
- CAS DataBase Reference
- 5018-41-7(CAS DataBase Reference)
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- A595470
- Product name
- 4-Amino-6-chloro-5-methoxypyrimidine
- Packaging
- 500mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- L625
- Product name
- 4-Amino-6-chloro-5-methoxypyrimidine
- Packaging
- 100mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 101625
- Product name
- 4-Amino-5-methoxy-6-chloropyrimidine
- Purity
- 98%
- Packaging
- 5g
- Price
- $374
- Updated
- 2021/12/16
- Product number
- HCH0012845
- Product name
- 4-AMINO-6-CHLORO-5-METHOXYPYRIMIDINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $970.2
- Updated
- 2021/12/16
- Product number
- 101625
- Product name
- 4-Amino-5-methoxy-6-chloropyrimidine
- Purity
- 98%
- Packaging
- 25g
- Price
- $1170
- Updated
- 2021/12/16
4-Amino-6-chloro-5-methoxypyrimidine Chemical Properties,Usage,Production
Synthesis
5018-38-2
5018-41-7
General procedure for the synthesis of 4-sulfo-5-methoxy-6-chloropyrimidine from 4,6-dichloro-5-methoxypyrimidine: a mixture of 4,6-dichloro-5-methoxypyrimidine (5.0 g, 28.1 mmol), 30% ammonia (45 mL), and n-butanol (15 mL) was heated and reacted in a sealed tube for 8 hr at 85 °C. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure and the concentrate was subsequently suspended in brine (150 mL). A white precipitate was collected by filtration and the filter cake was recrystallized from ethanol to afford the target compound 4-sulfo-5-methoxy-6-chloropyrimidine as an off-white solid in a yield of 4.1 g in 90% yield. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 7.97 (s, 1H), 7.29 (s, 2H), 3.71 (s, 3H). Mass spectrum (ESI, cation mode) showed m/z: 159.91 [M + H]+.
References
[1] European Journal of Medicinal Chemistry, 2018, vol. 143, p. 1148 - 1164
[2] Patent: CN108164548, 2018, A. Location in patent: Paragraph 0209; 0210; 0211
[3] Organic Process Research and Development, 2015, vol. 19, # 6, p. 639 - 645
[4] Patent: WO2005/47279, 2005, A1. Location in patent: Page/Page column 33
4-Amino-6-chloro-5-methoxypyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Amino-6-chloro-5-methoxypyrimidine manufacturers
- Product
- 4-Amino-6-chloro-5-methoxypyrimidine 5018-41-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-13
- Product
- 4-Amino-6-chloro-5-methoxypyrimidine 5018-41-7
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-09