ChemicalBook > CAS DataBase List > 4-Amino-6-chloro-5-methoxypyrimidine

4-Amino-6-chloro-5-methoxypyrimidine

Product Name
4-Amino-6-chloro-5-methoxypyrimidine
CAS No.
5018-41-7
Chemical Name
4-Amino-6-chloro-5-methoxypyrimidine
Synonyms
6-CHLORO-5-METHOXYPYRIMIDIN-4-AMINE;6-Chloro-5-methoxy-4-pyrimidinamine;4-Amino-6-Chloro-5-Methoxy Pyrimidin;4-AMINO-6-CHLORO-5-METHOXYPYRIMIDINE;6-Chloro-5-MethoxypyriMidin-4-ylaMine;4-Pyrimidinamine, 6-chloro-5-methoxy-;4-Amino-6-chloro-5-methoxypyrimidine ISO 9001：2015 REACH;4-(p-AMinobenzene SulfonaMino)-5Methoxy-6-Chloro PyriMidine)
CBNumber
CB8433466
Molecular Formula
C5H6ClN3O
Formula Weight
159.57
MOL File
5018-41-7.mol
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4-Amino-6-chloro-5-methoxypyrimidine Property

Melting point:
176-178 °C
Boiling point:
305.4±37.0 °C(Predicted)
Density 
1.398±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
1.51±0.10(Predicted)
Appearance
White to off-white Solid
InChI
InChI=1S/C5H6ClN3O/c1-10-3-4(6)8-2-9-5(3)7/h2H,1H3,(H2,7,8,9)
InChIKey
AAJZJNHQPBMCFV-UHFFFAOYSA-N
SMILES
C1=NC(Cl)=C(OC)C(N)=N1
CAS DataBase Reference
5018-41-7(CAS DataBase Reference)
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Safety

HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC
Product number
A595470
Product name
4-Amino-6-chloro-5-methoxypyrimidine
Packaging
500mg
Price
$155
Updated
2021/12/16
AK Scientific
Product number
L625
Product name
4-Amino-6-chloro-5-methoxypyrimidine
Packaging
100mg
Price
$95
Updated
2021/12/16
Matrix Scientific
Product number
101625
Product name
4-Amino-5-methoxy-6-chloropyrimidine
Purity
98%
Packaging
5g
Price
$374
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0012845
Product name
4-AMINO-6-CHLORO-5-METHOXYPYRIMIDINE
Purity
95.00%
Packaging
1G
Price
$970.2
Updated
2021/12/16
Matrix Scientific
Product number
101625
Product name
4-Amino-5-methoxy-6-chloropyrimidine
Purity
98%
Packaging
25g
Price
$1170
Updated
2021/12/16
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4-Amino-6-chloro-5-methoxypyrimidine Chemical Properties,Usage,Production

Synthesis

5018-38-2

5018-41-7

General procedure for the synthesis of 4-sulfo-5-methoxy-6-chloropyrimidine from 4,6-dichloro-5-methoxypyrimidine: a mixture of 4,6-dichloro-5-methoxypyrimidine (5.0 g, 28.1 mmol), 30% ammonia (45 mL), and n-butanol (15 mL) was heated and reacted in a sealed tube for 8 hr at 85 °C. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure and the concentrate was subsequently suspended in brine (150 mL). A white precipitate was collected by filtration and the filter cake was recrystallized from ethanol to afford the target compound 4-sulfo-5-methoxy-6-chloropyrimidine as an off-white solid in a yield of 4.1 g in 90% yield. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 7.97 (s, 1H), 7.29 (s, 2H), 3.71 (s, 3H). Mass spectrum (ESI, cation mode) showed m/z: 159.91 [M + H]+.

References

[1] European Journal of Medicinal Chemistry, 2018, vol. 143, p. 1148 - 1164
[2] Patent: CN108164548, 2018, A. Location in patent: Paragraph 0209; 0210; 0211
[3] Organic Process Research and Development, 2015, vol. 19, # 6, p. 639 - 645
[4] Patent: WO2005/47279, 2005, A1. Location in patent: Page/Page column 33

4-Amino-6-chloro-5-methoxypyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Amino-6-chloro-5-methoxypyrimidine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4-Amino-6-chloro-5-methoxypyrimidine 5018-41-7
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-13
Career Henan Chemical Co
Product
4-Amino-6-chloro-5-methoxypyrimidine 5018-41-7
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-07-09

5018-41-7, 4-Amino-6-chloro-5-methoxypyrimidineRelated Search:

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  • 4-(p-AMinobenzene SulfonaMino)-5Methoxy-6-Chloro PyriMidine)
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  • 4-Amino-6-chloro-5-methoxypyrimidine ISO 9001：2015 REACH
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