ChemicalBook > CAS DataBase List > 1-TRIMETHYLSILYLMETHANOL

1-TRIMETHYLSILYLMETHANOL

Product Name
1-TRIMETHYLSILYLMETHANOL
CAS No.
3219-63-4
Chemical Name
1-TRIMETHYLSILYLMETHANOL
Synonyms
DK264;NSC 96777;rimethylsilylmethanol;(trimethylsilyl)-methano;1-TRIMETHYLSILYLMETHANOL;(TRIMETHYLSILYL)METHANOL;Methanol, (trimethylsilyl)-;TRIMETHYLHYDROXYMETHYLSILANE;Methanol,1-(trimethylsilyl)-;1-TRIMETHYLSILYLMETHANOL, 98+%
CBNumber
CB7284458
Molecular Formula
C4H12OSi
Formula Weight
104.22
MOL File
3219-63-4.mol
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1-TRIMETHYLSILYLMETHANOL Property

Melting point:
<0°C
Boiling point:
120-122 °C754 mm Hg(lit.)
Density 
0.826 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.419(lit.)
Flash point:
88 °F
storage temp. 
2-8°C
pka
15.92±0.10(Predicted)
form 
clear liquid
Specific Gravity
0.827
color 
Colorless to Almost colorless
Water Solubility 
Fully miscible in water.
Hydrolytic Sensitivity
1: no significant reaction with aqueous systems
BRN 
1731486
CAS DataBase Reference
3219-63-4(CAS DataBase Reference)
EPA Substance Registry System
Methanol, (trimethylsilyl)- (3219-63-4)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
RIDADR 
UN 1987 3/PG 3
WGK Germany 
3
RTECS 
PC4100000
TSCA 
Yes
HS Code 
2931.90.9010
HazardClass 
3
PackingGroup 
III
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
T1250
Product name
Trimethylsilylmethanol
Purity
>97.0%(GC)
Packaging
5mL
Price
$113
Updated
2024/03/01
TCI Chemical
Product number
T1250
Product name
Trimethylsilylmethanol
Purity
>97.0%(GC)
Packaging
25mL
Price
$389
Updated
2024/03/01
Alfa Aesar
Product number
L04251
Product name
1-Trimethylsilylmethanol, 95%
Packaging
1g
Price
$37.65
Updated
2024/03/01
Alfa Aesar
Product number
L04251
Product name
1-Trimethylsilylmethanol, 95%
Packaging
5g
Price
$156.65
Updated
2024/03/01
Usbiological
Product number
291767
Product name
Trimethylsilylmethanol
Packaging
2g
Price
$313
Updated
2021/12/16
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1-TRIMETHYLSILYLMETHANOL Chemical Properties,Usage,Production

Uses

1-Trimethylsilylmethanol is used as nucleophile to resolve the racemate obtained from enantioselective esterification of naproxen (2-(6-methoxy-2-naphthyl) propionic acid) by lipases. It was also used as a nucleophilic hydroxymethylation agent.

Purification Methods

If the NMR indicates impurities (should have only two signals), then dissolve it in Et2O, shake this with aqueous 5N NaOH, M H2SO4, saturated aqueous NaCl, dry (MgSO4) and distil it using an efficient column at atmospheric pressure. The 3,5-dinitrobenzoate has m 70-70.5o (from 95% EtOH). [Huang & Wang Acta Chem Sin 23 291 1957, cf. Chem Abstr 52 19911 1958, Speier et al. J Am Chem Soc 81 1844 1959 and Speier et al. J Am Chem Soc 70 1117 1948, Beilstein 4 III 1844, 4 IV 2876.]

1-TRIMETHYLSILYLMETHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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1-TRIMETHYLSILYLMETHANOL Suppliers

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View Lastest Price from 1-TRIMETHYLSILYLMETHANOL manufacturers

Hebei Mojin Biotechnology Co.,Ltd
Product
1-TRIMETHYLSILYLMETHANOL 3219-63-4
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000KG/month
Release date
2024-08-09
Career Henan Chemical Co
Product
1-TRIMETHYLSILYLMETHANOL 3219-63-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
KG/T
Release date
2019-12-17

3219-63-4, 1-TRIMETHYLSILYLMETHANOLRelated Search:

3-BROMO-1-(TRIMETHYLSILYL)-1-PROPYNE TRIMETHYLSILYL DIETHYLPHOSPHONOACETATE (TRIMETHYLSILYL)CYCLOPENTADIENE, MIXTURE OF ISOMERS TRIMETHYLSILYL PROPIONATE TRIMETHYLSILYL TRIFLUOROACETATE 1-TRIMETHYLSILYLMETHANOL (TRIMETHYLSILYL)METHYL TRIFLUOROMETHANESULFONATE 1-(TRIMETHYLSILYL)ETHANOL, 98 (METHOXYMETHYL)TRIMETHYLSILANE (1-ETHOXYVINYL)-TRIMETHYLSILANE ACRYLOXYMETHYLTRIMETHYLSILANE (PHENYLDIMETHYLSILYL)METHYL METHACRYLATE (1-HYDROXYALLYL)TRIMETHYLSILANE 1-TRIETHYLSILYL-4-(TRIETHLYLSILYLOXY)-1-BUTYNE METHACRYLOXYMETHYLTRIMETHYLSILANE (2',5'-bis-O-(tert-butyldimethylsilyl)-beta-ribofuranosyl)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine (1-METHOXYVINYL)TRIMETHYLSILANE TRIMETHYLSILYLMETHYL ACETATE

  • (hydroxymethyl)trimethyl-silan
  • (trimethylsilyl)-methano
  • Methanol, (trimethylsilyl)-
  • Silane, (hydroxymethyl)trimethyl-
  • TRIMETHYLHYDROXYMETHYLSILANE
  • (TRIMETHYLSILYL)METHANOL
  • 1-TRIMETHYLSILYLMETHANOL
  • (HYDROXYMETHYL)TRIMETHYLSILANE
  • 1-TRIMETHYLSILYLMETHANOL, 98+%
  • (Trimethylsilyl)methanol,(Hydroxymethyl)trimethylsilane
  • NSC 96777
  • Methanol,1-(trimethylsilyl)-
  • rimethylsilylmethanol
  • DK264
  • 3219-63-4
  • C4H12OSi
  • CH33SiCH2OH
  • Alcohols
  • Building Blocks
  • C2 to C6
  • Organic Building Blocks
  • Oxygen Compounds
  • Silicon Compounds (for Synthesis)
  • Si (Classes of Silicon Compounds)
  • Si-(C)4 Compounds
  • Si (Classes of Silicon Compounds)
  • Si-(C)4 Compounds
  • Silicon Compounds (for Synthesis)
  • Synthetic Organic Chemistry