(+)-AEROPLYSININ-1

Product Name: (+)-AEROPLYSININ-1
CAS No.: 28656-91-9
Chemical Name: (+)-AEROPLYSININ-1
Synonyms: NSC-170364;AEROPLYSININ;aeroplysinini;(+)-aeroplysinini;(+)-AEROPLYSININ-1;(+)shy-Aeroplysinin-1;Aeroplysinin (Aeroplysinin-1);AEROPLYSININ, APLYSINA AEROPHOBA;(+)-AEROPLYSININ-1, APLYSINA AEROPHOBA;4-cyclohexadiene-1-acetonitrile,3,5-dibromo-1,6-dihydroxy-4-methoxy-(1s-tr
CBNumber: CB7286568
Molecular Formula: C9H9Br2NO3
Formula Weight: 338.98
MOL File: 28656-91-9.mol

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(+)-AEROPLYSININ-1 Property

Boiling point:: 479.6±45.0 °C(Predicted)
Density: 2.01±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Methanol: Soluble
form: A solid
pka: 10.54±0.70(Predicted)

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Safety

HS Code: 2941900000

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21498
Product name: (+)-Aeroplysinin-1
Purity: ≥95%
Packaging: 100μg
Price: $117
Updated: 2024/03/01

TRC

Product number: A325708
Product name: (+)shy-Aeroplysinin-1
Packaging: 250μg
Price: $85
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0024893
Product name: (+)-AEROPLYSININ-1
Purity: 95.00%
Packaging: 5MG
Price: $501.71
Updated: 2021/12/16

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(+)-AEROPLYSININ-1 Chemical Properties,Usage,Production

Description

(+)-Aeroplysinin-1 is a metabolite originally isolated from the marine sponge V. aerophoba with diverse biological activities. (+)-Aeroplysinin-1 (0.25-0.5 μM) induces cell death in MCF-7 and ZR-75-1 human breast cancer cells in a time- and concentration-dependent manner but has no effect on normal human fibroblasts at concentrations up to 5 μM. It also blocks EGF-induced endocytosis of the EGF receptor (EGFR) and EGF-dependent cell proliferation in MCF-7 cells. (+)-Aeroplysinin-1 inhibits bovine aortic endothelial (BAE) cell proliferation and cord formation in a Matrigel™ assay. It inhibits angiogenesis in a dose-dependent manner in a chick chorioallantoic membrane (CAM) assay when administered from 1.5 to 3 nmol per egg. (+)-Aeroplysinin-1 also has antibacterial activity against Gram-positive bacteria, including S. aureus, S. albus, and B. subtilis, but not Gram-negative bacteria and inhibits HIV-1 replication (IC₅₀ = 14.6 μM) via inhibition of HIV-1 reverse transcriptase.

Uses

(+)shy-Aeroplysinin-1 is a compound that is an inhibitor of EGFR kinase.

Definition

ChEBI: Aeroplysinin 1 is a tertiary alcohol.

(+)-AEROPLYSININ-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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(+)-AEROPLYSININ-1 Suppliers

China 32 Switzerland 2 Ukraine 1 United Kingdom 3 United States 9 Global 47

Shanghai T&W Pharmaceutical Co., Ltd.

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Beijing Jin Ming Biotechnology Co., Ltd.

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BOC Sciences

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TargetMol Chemicals Inc.

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Energy Chemical

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Beijing Jin Ming Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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Shanghai Tachizaki Biomedical Research Center

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28656-91-9, (+)-AEROPLYSININ-1Related Search:

(+)-Aeroplysinin-1, Aplysina areophoba,(+)-Aeroplysinin-1, Aplysina areophoba 3-HYDROXY-3-METHYLBUTYRONITRILE 5-Bromo-1-pentene 5-Hexenenitrile (R)-(-)-3-HYDROXYBUTYRONITRILE (S)-3-Bromo-1,2-propanediol 5-BROMOVALERONITRILE (E)-2-BROMO-2-BUTEN-1-OL (+)-AEROPLYSININ-1 3-Bromo-3-buten-1-ol 1,3-DIBROMO-1-PROPENE 1-cyano-2-hydroxy-3-butene (S)-(+)-3-HYDROXYBUTYRONITRILE 5-Bromohex-5-enenitrile

(+)-aeroplysinini

(1s-trans)-3,5-dibromo-1,6-dihydroxy-4-methoxy-2,4-cyclohexadiene-1-acetonit

4-cyclohexadiene-1-acetonitrile,3,5-dibromo-1,6-dihydroxy-4-methoxy-(1s-tr

aeroplysinini

AEROPLYSININ

(+)-AEROPLYSININ-1

(+)-AEROPLYSININ-1, APLYSINA AEROPHOBA

AEROPLYSININ, APLYSINA AEROPHOBA

(1S)-1,6α-Dihydroxy-3,5-dibromo-4-methoxy-2,4-cyclohexadiene-1α-acetonitrile

[1S,6R,(+)]-3,5-Dibromo-1,6-dihydroxy-4-methoxy-2,4-cyclohexadiene-1-acetonitrile

NSC-170364

(1R)-1,6β-Dihydroxy-3,5-dibromo-4-methoxy-2,4-cyclohexadiene-1β-acetonitrile

(1R)-3,5-Dibromo-1α,6β-dihydroxy-4-methoxy-2,4-cyclohexadiene-1β-acetonitrile

Aeroplysinin (Aeroplysinin-1)

(+)shy-Aeroplysinin-1

2,4-Cyclohexadiene-1-acetonitrile, 3,5-dibromo-1,6-dihydroxy-4-methoxy-, (1S,6R)-

28656-91-9

C9H9Br2NO3