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(+)-AEROPLYSININ-1

Product Name
(+)-AEROPLYSININ-1
CAS No.
28656-91-9
Chemical Name
(+)-AEROPLYSININ-1
Synonyms
NSC-170364;AEROPLYSININ;aeroplysinini;(+)-aeroplysinini;(+)-AEROPLYSININ-1;(+)shy-Aeroplysinin-1;Aeroplysinin (Aeroplysinin-1);AEROPLYSININ, APLYSINA AEROPHOBA;(+)-AEROPLYSININ-1, APLYSINA AEROPHOBA;4-cyclohexadiene-1-acetonitrile,3,5-dibromo-1,6-dihydroxy-4-methoxy-(1s-tr
CBNumber
CB7286568
Molecular Formula
C9H9Br2NO3
Formula Weight
338.98
MOL File
28656-91-9.mol
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(+)-AEROPLYSININ-1 Property

Boiling point:
479.6±45.0 °C(Predicted)
Density 
2.01±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Methanol: Soluble
form 
A solid
pka
10.54±0.70(Predicted)
color 
Colorless to off-white
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Safety

HS Code 
2941900000
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21498
Product name
(+)-Aeroplysinin-1
Purity
≥95%
Packaging
100μg
Price
$117
Updated
2024/03/01
TRC
Product number
A325708
Product name
(+)shy-Aeroplysinin-1
Packaging
250μg
Price
$85
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0024893
Product name
(+)-AEROPLYSININ-1
Purity
95.00%
Packaging
5MG
Price
$501.71
Updated
2021/12/16
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(+)-AEROPLYSININ-1 Chemical Properties,Usage,Production

Description

(+)-Aeroplysinin-1 is a metabolite originally isolated from the marine sponge V. aerophoba with diverse biological activities. (+)-Aeroplysinin-1 (0.25-0.5 μM) induces cell death in MCF-7 and ZR-75-1 human breast cancer cells in a time- and concentration-dependent manner but has no effect on normal human fibroblasts at concentrations up to 5 μM. It also blocks EGF-induced endocytosis of the EGF receptor (EGFR) and EGF-dependent cell proliferation in MCF-7 cells. (+)-Aeroplysinin-1 inhibits bovine aortic endothelial (BAE) cell proliferation and cord formation in a Matrigel™ assay. It inhibits angiogenesis in a dose-dependent manner in a chick chorioallantoic membrane (CAM) assay when administered from 1.5 to 3 nmol per egg. (+)-Aeroplysinin-1 also has antibacterial activity against Gram-positive bacteria, including S. aureus, S. albus, and B. subtilis, but not Gram-negative bacteria and inhibits HIV-1 replication (IC50 = 14.6 μM) via inhibition of HIV-1 reverse transcriptase.

Uses

(+)shy-Aeroplysinin-1 is a compound that is an inhibitor of EGFR kinase.

Definition

ChEBI: Aeroplysinin 1 is a tertiary alcohol.

(+)-AEROPLYSININ-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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(+)-AEROPLYSININ-1 Suppliers

Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
BOC Sciences
Tel
16314854226; +16314854226
Email
inquiry@bocsci.com
Country
United States
ProdList
19741
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32063
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11217
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29774
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24648
Advantage
58
Shanghai Tachizaki Biomedical Research Center
Tel
18014399201
Email
sales@chemlab-tachizaki.com
Country
China
ProdList
2560
Advantage
58

28656-91-9, (+)-AEROPLYSININ-1Related Search:


  • (+)-aeroplysinini
  • (1s-trans)-3,5-dibromo-1,6-dihydroxy-4-methoxy-2,4-cyclohexadiene-1-acetonit
  • 4-cyclohexadiene-1-acetonitrile,3,5-dibromo-1,6-dihydroxy-4-methoxy-(1s-tr
  • aeroplysinini
  • AEROPLYSININ
  • (+)-AEROPLYSININ-1
  • (+)-AEROPLYSININ-1, APLYSINA AEROPHOBA
  • AEROPLYSININ, APLYSINA AEROPHOBA
  • (1S)-1,6α-Dihydroxy-3,5-dibromo-4-methoxy-2,4-cyclohexadiene-1α-acetonitrile
  • [1S,6R,(+)]-3,5-Dibromo-1,6-dihydroxy-4-methoxy-2,4-cyclohexadiene-1-acetonitrile
  • NSC-170364
  • (1R)-1,6β-Dihydroxy-3,5-dibromo-4-methoxy-2,4-cyclohexadiene-1β-acetonitrile
  • (1R)-3,5-Dibromo-1α,6β-dihydroxy-4-methoxy-2,4-cyclohexadiene-1β-acetonitrile
  • Aeroplysinin (Aeroplysinin-1)
  • (+)shy-Aeroplysinin-1
  • 2,4-Cyclohexadiene-1-acetonitrile, 3,5-dibromo-1,6-dihydroxy-4-methoxy-, (1S,6R)-
  • 28656-91-9
  • C9H9Br2NO3