(+)-AEROPLYSININ-1
- Product Name
- (+)-AEROPLYSININ-1
- CAS No.
- 28656-91-9
- Chemical Name
- (+)-AEROPLYSININ-1
- Synonyms
- NSC-170364;AEROPLYSININ;aeroplysinini;(+)-aeroplysinini;(+)-AEROPLYSININ-1;(+)shy-Aeroplysinin-1;Aeroplysinin (Aeroplysinin-1);AEROPLYSININ, APLYSINA AEROPHOBA;(+)-AEROPLYSININ-1, APLYSINA AEROPHOBA;4-cyclohexadiene-1-acetonitrile,3,5-dibromo-1,6-dihydroxy-4-methoxy-(1s-tr
- CBNumber
- CB7286568
- Molecular Formula
- C9H9Br2NO3
- Formula Weight
- 338.98
- MOL File
- 28656-91-9.mol
(+)-AEROPLYSININ-1 Property
- Boiling point:
- 479.6±45.0 °C(Predicted)
- Density
- 2.01±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Methanol: Soluble
- form
- A solid
- pka
- 10.54±0.70(Predicted)
- color
- Colorless to off-white
Safety
- HS Code
- 2941900000
N-Bromosuccinimide Price
- Product number
- 21498
- Product name
- (+)-Aeroplysinin-1
- Purity
- ≥95%
- Packaging
- 100μg
- Price
- $117
- Updated
- 2024/03/01
- Product number
- A325708
- Product name
- (+)shy-Aeroplysinin-1
- Packaging
- 250μg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- API0024893
- Product name
- (+)-AEROPLYSININ-1
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.71
- Updated
- 2021/12/16
(+)-AEROPLYSININ-1 Chemical Properties,Usage,Production
Description
(+)-Aeroplysinin-1 is a metabolite originally isolated from the marine sponge V. aerophoba with diverse biological activities. (+)-Aeroplysinin-1 (0.25-0.5 μM) induces cell death in MCF-7 and ZR-75-1 human breast cancer cells in a time- and concentration-dependent manner but has no effect on normal human fibroblasts at concentrations up to 5 μM. It also blocks EGF-induced endocytosis of the EGF receptor (EGFR) and EGF-dependent cell proliferation in MCF-7 cells. (+)-Aeroplysinin-1 inhibits bovine aortic endothelial (BAE) cell proliferation and cord formation in a Matrigel™ assay. It inhibits angiogenesis in a dose-dependent manner in a chick chorioallantoic membrane (CAM) assay when administered from 1.5 to 3 nmol per egg. (+)-Aeroplysinin-1 also has antibacterial activity against Gram-positive bacteria, including S. aureus, S. albus, and B. subtilis, but not Gram-negative bacteria and inhibits HIV-1 replication (IC50 = 14.6 μM) via inhibition of HIV-1 reverse transcriptase.
Uses
(+)shy-Aeroplysinin-1 is a compound that is an inhibitor of EGFR kinase.
Definition
ChEBI: Aeroplysinin 1 is a tertiary alcohol.
(+)-AEROPLYSININ-1 Preparation Products And Raw materials
Raw materials
Preparation Products
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