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(+)-AEROPLYSININ-1

Product Name
(+)-AEROPLYSININ-1
CAS No.
28656-91-9
Chemical Name
(+)-AEROPLYSININ-1
Synonyms
NSC-170364;AEROPLYSININ;aeroplysinini;(+)-aeroplysinini;(+)-AEROPLYSININ-1;(+)shy-Aeroplysinin-1;Aeroplysinin (Aeroplysinin-1);AEROPLYSININ, APLYSINA AEROPHOBA;(+)-AEROPLYSININ-1, APLYSINA AEROPHOBA;4-cyclohexadiene-1-acetonitrile,3,5-dibromo-1,6-dihydroxy-4-methoxy-(1s-tr
CBNumber
CB7286568
Molecular Formula
C9H9Br2NO3
Formula Weight
338.98
MOL File
28656-91-9.mol
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(+)-AEROPLYSININ-1 Property

Boiling point:
479.6±45.0 °C(Predicted)
Density 
2.01±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Methanol: Soluble
form 
A solid
pka
10.54±0.70(Predicted)
color 
Colorless to off-white
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Safety

HS Code 
2941900000
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21498
Product name
(+)-Aeroplysinin-1
Purity
≥95%
Packaging
100μg
Price
$117
Updated
2024/03/01
TRC
Product number
A325708
Product name
(+)shy-Aeroplysinin-1
Packaging
250μg
Price
$85
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0024893
Product name
(+)-AEROPLYSININ-1
Purity
95.00%
Packaging
5MG
Price
$501.71
Updated
2021/12/16
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(+)-AEROPLYSININ-1 Chemical Properties,Usage,Production

Description

(+)-Aeroplysinin-1 is a metabolite originally isolated from the marine sponge V. aerophoba with diverse biological activities. (+)-Aeroplysinin-1 (0.25-0.5 μM) induces cell death in MCF-7 and ZR-75-1 human breast cancer cells in a time- and concentration-dependent manner but has no effect on normal human fibroblasts at concentrations up to 5 μM. It also blocks EGF-induced endocytosis of the EGF receptor (EGFR) and EGF-dependent cell proliferation in MCF-7 cells. (+)-Aeroplysinin-1 inhibits bovine aortic endothelial (BAE) cell proliferation and cord formation in a Matrigel™ assay. It inhibits angiogenesis in a dose-dependent manner in a chick chorioallantoic membrane (CAM) assay when administered from 1.5 to 3 nmol per egg. (+)-Aeroplysinin-1 also has antibacterial activity against Gram-positive bacteria, including S. aureus, S. albus, and B. subtilis, but not Gram-negative bacteria and inhibits HIV-1 replication (IC50 = 14.6 μM) via inhibition of HIV-1 reverse transcriptase.

Uses

(+)shy-Aeroplysinin-1 is a compound that is an inhibitor of EGFR kinase.

Definition

ChEBI: Aeroplysinin 1 is a tertiary alcohol.

(+)-AEROPLYSININ-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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(+)-AEROPLYSININ-1 Suppliers

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28656-91-9, (+)-AEROPLYSININ-1Related Search:

(+)-Aeroplysinin-1, Aplysina areophoba,(+)-Aeroplysinin-1, Aplysina areophoba 3-HYDROXY-3-METHYLBUTYRONITRILE 5-Bromo-1-pentene 5-Hexenenitrile (R)-(-)-3-HYDROXYBUTYRONITRILE (S)-3-Bromo-1,2-propanediol 5-BROMOVALERONITRILE (E)-2-BROMO-2-BUTEN-1-OL (+)-AEROPLYSININ-1 3-Bromo-3-buten-1-ol 1,3-DIBROMO-1-PROPENE 1-cyano-2-hydroxy-3-butene (S)-(+)-3-HYDROXYBUTYRONITRILE 5-Bromohex-5-enenitrile

  • (+)-aeroplysinini
  • (1s-trans)-3,5-dibromo-1,6-dihydroxy-4-methoxy-2,4-cyclohexadiene-1-acetonit
  • 4-cyclohexadiene-1-acetonitrile,3,5-dibromo-1,6-dihydroxy-4-methoxy-(1s-tr
  • aeroplysinini
  • AEROPLYSININ
  • (+)-AEROPLYSININ-1
  • (+)-AEROPLYSININ-1, APLYSINA AEROPHOBA
  • AEROPLYSININ, APLYSINA AEROPHOBA
  • (1S)-1,6α-Dihydroxy-3,5-dibromo-4-methoxy-2,4-cyclohexadiene-1α-acetonitrile
  • [1S,6R,(+)]-3,5-Dibromo-1,6-dihydroxy-4-methoxy-2,4-cyclohexadiene-1-acetonitrile
  • NSC-170364
  • (1R)-1,6β-Dihydroxy-3,5-dibromo-4-methoxy-2,4-cyclohexadiene-1β-acetonitrile
  • (1R)-3,5-Dibromo-1α,6β-dihydroxy-4-methoxy-2,4-cyclohexadiene-1β-acetonitrile
  • Aeroplysinin (Aeroplysinin-1)
  • (+)shy-Aeroplysinin-1
  • 2,4-Cyclohexadiene-1-acetonitrile, 3,5-dibromo-1,6-dihydroxy-4-methoxy-, (1S,6R)-
  • 28656-91-9
  • C9H9Br2NO3