ChemicalBook > CAS DataBase List > (R)-5-Amino-1-(1-cyanopiperidin-3-yl)-3-(4-[2,4-difluorophenoxy]phenyl)-1H-pyrazole-4-carboxamide

(R)-5-Amino-1-(1-cyanopiperidin-3-yl)-3-(4-[2,4-difluorophenoxy]phenyl)-1H-pyrazole-4-carboxamide

Product Name
(R)-5-Amino-1-(1-cyanopiperidin-3-yl)-3-(4-[2,4-difluorophenoxy]phenyl)-1H-pyrazole-4-carboxamide
CAS No.
1609465-89-5
Chemical Name
(R)-5-Amino-1-(1-cyanopiperidin-3-yl)-3-(4-[2,4-difluorophenoxy]phenyl)-1H-pyrazole-4-carboxamide
Synonyms
PF-06250112;PF06250112,PF 06250112;(R)-5-Amino-1-(1-cyanopiperidin-3-yl)-3-(4-[2,4-difluorophenoxy]phenyl)-1H-pyrazole-4-carboxamide;1H-Pyrazole-4-carboxamide, 5-amino-1-[(3S)-1-cyano-3-piperidinyl]-3-[4-(2,4-difluorophenoxy)phenyl]-
CBNumber
CB72891555
Molecular Formula
C22H20F2N6O2
Formula Weight
438.43
MOL File
1609465-89-5.mol
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(R)-5-Amino-1-(1-cyanopiperidin-3-yl)-3-(4-[2,4-difluorophenoxy]phenyl)-1H-pyrazole-4-carboxamide Property

Boiling point:
643.6±55.0 °C(Predicted)
Density 
1.46±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO
form 
powder
pka
14.99±0.50(Predicted)
color 
white to beige
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
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Hazard and Precautionary Statements (GHS)

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(R)-5-Amino-1-(1-cyanopiperidin-3-yl)-3-(4-[2,4-difluorophenoxy]phenyl)-1H-pyrazole-4-carboxamide Chemical Properties,Usage,Production

Biological Activity

PF-06250112 is a potent inhibitor of Brutonμs tyrosine kinase (BTK). PF-06250112 blocks both B-cell receptor and FcR-mediated signaling, and prevents FcR-dependent, Antibody-mediated proteinuria in a mouse glomerulonephritis model.

(R)-5-Amino-1-(1-cyanopiperidin-3-yl)-3-(4-[2,4-difluorophenoxy]phenyl)-1H-pyrazole-4-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-5-Amino-1-(1-cyanopiperidin-3-yl)-3-(4-[2,4-difluorophenoxy]phenyl)-1H-pyrazole-4-carboxamide Suppliers

China 2 United States 5 Global 7
TargetMol Chemicals Inc.
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+1-781-999-5354 +1-00000000000
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TargetMol Chemicals Inc.
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+8613564774135
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zijue.cai@tsbiochem.com
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United States
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19881
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TargetMol Chemicals Inc.
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support@targetmol.com
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United States
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MedChemExpress
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Riedel-de Haen AG
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1609465-89-5, (R)-5-Amino-1-(1-cyanopiperidin-3-yl)-3-(4-[2,4-difluorophenoxy]phenyl)-1H-pyrazole-4-carboxamideRelated Search:


  • (R)-5-Amino-1-(1-cyanopiperidin-3-yl)-3-(4-[2,4-difluorophenoxy]phenyl)-1H-pyrazole-4-carboxamide
  • PF-06250112
  • 1H-Pyrazole-4-carboxamide, 5-amino-1-[(3S)-1-cyano-3-piperidinyl]-3-[4-(2,4-difluorophenoxy)phenyl]-
  • PF06250112,PF 06250112
  • 1609465-89-5