Interleukin-25
Description Source Background- Product Name
- Interleukin-25
- Chemical Name
- Interleukin-25
- Synonyms
- IL25;IL17E;IL27w;UNQ3120;R33729_1;PRO10272;IL-17E human;InterleukinE;IL-17E murine;Interleukin-25
- CBNumber
- CB72902660
- Formula Weight
- 0
- MOL File
- Mol file
Interleukin-25 Property
- storage temp.
- -20°C
- form
- lyophilized
- color
- white
- biological source
- mouse
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- SRP3313
- Product name
- IL-17E human
- Purity
- Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
- Packaging
- 25μg
- Price
- $415
- Updated
- 2025/07/31
- Product number
- SRP3235
- Product name
- SF-20 from mouse
- Purity
- recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
- Packaging
- 10μG
- Price
- $368
- Updated
- 2025/07/31
- Product number
- SRP6249
- Product name
- IL-17E human
- Purity
- recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
- Packaging
- 10μG
- Price
- $448
- Updated
- 2023/01/07
- Product number
- 155415
- Product name
- Interleukin 25
- Packaging
- 10ug
- Price
- $339
- Updated
- 2021/12/16
- Product number
- 026202
- Product name
- Interleukin 25
- Packaging
- 96Tests
- Price
- $851
- Updated
- 2021/12/16
Interleukin-25 Chemical Properties,Usage,Production
General Description
IL-17E is a disulfide-linked homodimer of two 145 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17E stimulated secretion of IL-8, and induces activation of the transcription factor NF-?B in cells that express the IL-17BR receptor. Recombinant human IL-17E is a 33.8 kDa disulfide-linked homodimer of two 146 amino acid polypeptide chains.
Biochem/physiol Actions
IL-17E is a disulfide-linked homodimer of two 145 amino acid polypeptide chains.
Description
Interleukin-17E Human Recombinant produced in E.Coli is a non-glycosylated disulfide-linked homodimer containing 2x145 amino acids (with an N-terminal Methionine for each chain total aa for each chain 146) and having a total predicted molecular mass of 33.7kDa.
The IL-25 Human is purified by proprietary chromatographic techniques.
Source
Escherichia Coli
Background
IL-25 also called IL-17E cytokine has a sequence similarity with IL17. IL-17E indluces NF-kappaB activation, and stimulates the production of IL-8. IL17E and IL17B are ligands for the cytokine receptor IL17BR. IL-25 is a proinflammatory cytokine favoring Th2-type immune response. The upregulation of costimulation-induced IL-17E receptors and release of cytokines and chemokines from IL-17E treated costimulated Th cells are differentially regulated by intracellular JNK, p38 MAPK and NF-kappaB activity. Blocking Iinterleukin-25 prevents airway hyperresponsiveness, a critical feature of clinical asthma. IL25 produced by innate effector eosinophils and basophils increase the allergic inflammation by enhancing the maintenance and functions of TSLP-DC activated adaptive Th2 memory cells. Over expression of IL-25 up-regulates gene expression of Th2 cytokines and induces growth retardation, jaundice, and multiorgan inflammation in a transgenic mouse model. IL-25 contributes to the induction and maintenance of eosinophilic inflammation by acting on lung fibroblasts which supports the fact that IL-17E is an important factor in asthma pathophysiology. IL-17E operates by amplifying TH2 cell-mediated allergic airway inflammation but doesn’t induce allergic inflammation in vivo.
Interleukin-25 Preparation Products And Raw materials
Raw materials
Preparation Products
Interleukin-25 Suppliers
- Tel
- 027-65317797 15926423062
- Fax
- QQ：422450190
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- China
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