sir2-like 6
Description Source Background- Product Name
- sir2-like 6
- CAS No.
- 1391452-80-4
- Chemical Name
- sir2-like 6
- Synonyms
- SIRT6;SIR2L6;sir2-like 6;Sirtuin 6 human;SIRT6 human ;Rabbit Anti-SIRT6 antibody;SIRT6, active, His tagged human;NAD-dependent ADP-ribosyltransferase sirtuin-6;Sirtuin (silent mating type information regulation 2 homolog) 6
- CBNumber
- CB72923032
- Formula Weight
- 0
- MOL File
- Mol file
sir2-like 6 Property
- storage temp.
- -70°C
- form
- buffered aqueous glycerol solution
- biological source
- human
- Specific Activity
- 96-144RLU/min·ng
N-Bromosuccinimide Price
- Product number
- SRP5273
- Product name
- SIRT6, active, His tagged human
- Purity
- recombinant, expressed in baculovirus infected <I>Sf</I>9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
- Packaging
- 10 μg
- Price
- $636
- Updated
- 2025/07/31
- Product number
- SRP0120
- Product name
- Sirtuin 6 human
- Purity
- recombinant, expressed in <I>E. coli</I>, ≥70% (SDS-PAGE)
- Packaging
- 100 μg
- Price
- $672
- Updated
- 2025/07/31
- Product number
- 491775
- Product name
- SIRT6
- Packaging
- 100ul
- Price
- $499
- Updated
- 2021/12/16
- Product number
- 358869
- Product name
- SIRT6
- Packaging
- 48Tests
- Price
- $588
- Updated
- 2021/12/16
- Product number
- orb529677
- Product name
- SIRT6
- Packaging
- 10μg
- Price
- $596.7
- Updated
- 2021/12/16
sir2-like 6 Chemical Properties,Usage,Production
Uses
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Biological Activity
Sirtuin 6 (Sir6) is a mono-ADP-ribosyltransferase, which catalyzes the transfer of ADP-ribose moiety from NAD to itself and histones. It has been implicated in the regulation of DNA repair, genomic stability and telomere integrity, gene expression, and metabolism. In addition, it also prevents age-related disorders and premature aging. Sir6 plays a vital role in the inhibition of nuclear factor-KB (NF-KB)–mediated inflammatory responses in rheumatoid joints. Hence, Sir6 is considered to be a potent target for treatment of rheumatoid arthritis (RA). Sir6 is also majorly implicated in the regulation of glucose and f at metabolism. Sir6 prevent cardiac hypertrophy in vitro via inhibiting NF-KB-dependent transcriptional activity and this effect is relied on its deacetylase activity.
Description
SIRT6 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 375 amino acids (1-355 a.a.) and having a molecular mass of 41 kDa. Recombinant SIRT6 is fused to 20 amino acids His-tag at N-terminus and purified by conventional chromatography techniques.
Source
Escherichia Coli
Background
SIRT6 is part of the sirtuin family of proteins (Class IV), homologs to the yeast Sir2 protein. SIRT6 is characterized by a sirtuin core domain. Yeast sirtuin proteins are recognized by their ability to regulate epigenetic gene silencing and suppress recombination of rDNA. SIRT6, a chromatin-associated protein is involved in DNA repair. Human Sirtuins function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity.
sir2-like 6 Preparation Products And Raw materials
Raw materials
Preparation Products
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