Iminodibenzyl
- Product Name
- Iminodibenzyl
- CAS No.
- 494-19-9
- Chemical Name
- Iminodibenzyl
- Synonyms
- 10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPINE;2,2'-IMINODIBENZYL;10,11-DIHYDRO-5H-DIBENZ[B,F]AZEPINE;RP 23669;NSC 72110;Iminobibenzyl;IMINODIBENZYL;IMIDODIBENZYL;lminodibenzyl;Iminodibenzyyl
- CBNumber
- CB7294729
- Molecular Formula
- C14H13N
- Formula Weight
- 195.26
- MOL File
- 494-19-9.mol
Iminodibenzyl Property
- Melting point:
- 105-108 °C (lit.)
- Boiling point:
- 321.94°C (rough estimate)
- Density
- 1.0778 (rough estimate)
- refractive index
- 1.6353 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly, Heated), Methanol (Slightly)
- form
- Crystalline Powder
- pka
- 0.83±0.20(Predicted)
- color
- Yellow to beige
- BRN
- 152732
- InChI
- InChI=1S/C14H13N/c1-3-7-13-11(5-1)9-10-12-6-2-4-8-14(12)15-13/h1-8,15H,9-10H2
- InChIKey
- ZSMRRZONCYIFNB-UHFFFAOYSA-N
- SMILES
- N1C2=CC=CC=C2CCC2=CC=CC=C12
- LogP
- 4.27
- CAS DataBase Reference
- 494-19-9(CAS DataBase Reference)
- NIST Chemistry Reference
- 5H-Dibenz[b,f]azepine, 10,11-dihydro-(494-19-9)
- EPA Substance Registry System
- 5H-Dibenz[b,f]azepine, 10,11-dihydro- (494-19-9)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36-36/37/38
- Safety Statements
- 22-24/25-39-26-36/37/39-27
- WGK Germany
- 3
- RTECS
- HN8950000
- TSCA
- Yes
- HazardClass
- IRRITANT
- HS Code
- 29339930
N-Bromosuccinimide Price
- Product number
- I1308
- Product name
- 10,11-Dihydro-5H-dibenz[b,f]azepine
- Purity
- 97%
- Packaging
- 25g
- Price
- $53.1
- Updated
- 2025/07/31
- Product number
- 1337004
- Product name
- Iminodibenzyl
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 25mg
- Price
- $1200
- Updated
- 2025/07/31
- Product number
- D0269
- Product name
- 10,11-Dihydro-5H-dibenzo[b,f]azepine
- Purity
- >97.0%(N)
- Packaging
- 25g
- Price
- $28
- Updated
- 2025/07/31
- Product number
- PHR1795
- Product name
- Iminodibenzyl
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 100mg
- Price
- $858.8
- Updated
- 2025/07/31
- Product number
- 009721
- Product name
- 10,11-Dihydro-5H-dibenzo[b,f]azepine
- Packaging
- 10g
- Price
- $312
- Updated
- 2021/12/16
Iminodibenzyl Chemical Properties,Usage,Production
Description
Iminodibenzyl was not a new drug. It had been discovered in 1898 and used briefly as an intermediate, in the preparation of Sky Blue, a dye stuff. Iminodibenzyl, however, had a tricyclic ring structure, similar in appearance to the phenothiazines. Iminodibenzyl is an important drug intermediate, which can be used for the medicine synthesis as a tristimania and epilepsia.
Chemical Properties
YELLOWISH TO BEIGE CRYSTALLINE POWDER
Uses
10,11-Dihydro-5H-dibenzo[b,f]azepine is a metabolite of the tricyclic antidepressant, Imipramine (I465980). 10,11-Dihydro-5H-dibenzo[b,f]azepine can be used as a chromogenic probe for the quantification of hydrogen peroxide and glucose.
Uses
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Preparation
Iminodibenzyl is obtained from o-nitrotoluene by condensation, reduction and cyclization.
General Description
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Synthesis
13080-75-6
494-19-9
The general procedure for the synthesis of iminodibenzylidene from 1-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)ethanone is as follows: NaOH and triethylboron were stirred and mixed under argon protection at room temperature to form a clear, clarified solution with a concentration of 1 M/L. Subsequently, 10 μmol (2 mol%) of catalyst, 5 mmol of amide substrate, and 15 mmol of triethoxysilane or polymethylhydrosiloxane (PMHS) were sequentially added to the above triethylboron solution. The reaction mixture was added to a 10 mL sealed tube along with 2 mL of methyl tert-butyl ether (MTBE) and placed in an 80 °C oil bath with heating and stirring for 6 hours. Upon completion of the reaction, the reaction system was exposed to air and the amine products were subsequently isolated directly by column chromatography. According to the column chromatographic separation, the yield of iminodibenzyl was when triethoxysilane or polymethylhydrosiloxane (PMHS) was used as the reducing agent:
References
[1] Patent: CN107337573, 2017, A. Location in patent: Paragraph 0022; 0023; 0024; 0025
Iminodibenzyl Preparation Products And Raw materials
Raw materials
Preparation Products
Iminodibenzyl Suppliers
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- Country
- Switzerland
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- 411
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- Switzerland
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View Lastest Price from Iminodibenzyl manufacturers
- Product
- Iminodibenzyl 494-19-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 20tons
- Release date
- 2025-09-02
- Product
- Iminodibenzyl 494-19-9
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2024-11-13
- Product
- Iminodibenzyl 494-19-9
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-11-25