Dorzolamide Hydrochloride
- Product Name
- Dorzolamide Hydrochloride
- CAS No.
- 130693-82-2
- Chemical Name
- Dorzolamide Hydrochloride
- Synonyms
- MK 507;mk-0507;CS-1398;Trusopt;Biosopt;L 671152;Dorzalamide;TRUSOPT; COSOPT;DORZOLAMIDE HCL;Dorzolamide HCI
- CBNumber
- CB7296763
- Molecular Formula
- C10H17ClN2O4S3
- Formula Weight
- 360.9
- MOL File
- 130693-82-2.mol
Dorzolamide Hydrochloride Property
- Melting point:
- 265-2670C
- alpha
- D24 -8.34° (c = 1 in methanol)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- Soluble in water, slightly soluble in methanol, very slightly soluble in anhydrous ethanol.
- color
- White to Off-White
- λmax
- 254nm(CHCl3:MeOH= aq.)(lit.)
- Merck
- 14,3426
- BRN
- 5896026
- CAS DataBase Reference
- 130693-82-2(CAS DataBase Reference)
Safety
- WGK Germany
- 3
- RTECS
- XJ9095163
- HS Code
- 2935904000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P314Get medical advice/attention if you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- PHR1925
- Product name
- Dorzolamide hydrochloride
- Packaging
- 500mg
- Price
- $302
- Updated
- 2024/03/01
- Product number
- 1225281
- Product name
- Dorzolamide hydrochloride
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- D4189
- Product name
- Dorzolamide Hydrochloride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 200mg
- Price
- $177
- Updated
- 2024/03/01
- Product number
- 26303
- Product name
- Dorzolamide (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 14616
- Product name
- Dorzolamide (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $43
- Updated
- 2023/06/20
Dorzolamide Hydrochloride Chemical Properties,Usage,Production
Description
Dorzolamide hydrochloride was introduced in the U.S.A. as eye drops for the treatment of open-angle glaucoma and ocular hypertension. Dorzolamide is a potent carbonic anhydrase inhibitor that, on topical administration, lowers intraocular pressure (IOP). In a clinical study in patients with bilateral primary open-angle glaucoma or ocular hypertension, dorzolamide (0.7-2%) was found to significantly lower IOP throughout the day. Dorzolamide has been shown to be effective as a single therapy or in combination with β-blockers.
Description
Dorzolamide (hydrochloride) (Item No. 26303) is an analytical reference standard categorized as a carbonic anhydrase inhibitor diuretic. Diuretics have been used in sports doping to reduce weight or anabolic androgenic steroid-induced water retention, or as masking agents. This product is intended for use in analytical forensic applications. This product is also available as a general research tool .
Chemical Properties
White Powder
Originator
Merck (U.S.A.)
Uses
Carbonic anhydrase inhibitor. Antiglaucoma agent.
Uses
Antiglaucoma drug;Carbonic anhydrase inhibitor
Uses
analgesic
Uses
Dorzolamide HCl Ophthalmic Solution is indicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
Uses
An inhibitor of carbonic anhydrase.
Definition
ChEBI: The hydrochloride salt of dorzolamide. It is used in ophthalmic solutions to lower increased intraocular pressure in the treatment of open-angle glaucoma and ocular hypertension.
Manufacturing Process
Manufacturing process for Dorzolamide hydrochloride includes these steps as follows: Step A: Sulfuric Acid Ritter Procedure;Step B: Sulfonylation Procedure Step C: Chlorosulfonylation Procedure;Step D: Amidation Procedure;Step E: Reduction via Borane Generated in situ Procedure;Step F: Maleate Salt Formation Procedure;Step G: Crude Hydrochloride Salt Formation;Step H: Recrystallization Procedure.
brand name
Trusopt (Merck).
Therapeutic Function
Antiglaucoma
Veterinary Drugs and Treatments
Dorzolamide is often used in the contralateral eye of a dog with primary glaucoma to prevent development of bilateral disease. It is also an excellent agent to consider for most secondary glaucomas in dogs and cats because it has no effect on pupil size. Like the related oral carbonic anhydrase inhibitors (dichlorphenamide or Daranide?, methazolamide or Neptazane?), dorzolamide decreases aqueous humor production by the ciliary body epithelium by altering pH and affecting the H+/Na+ active transport exchange mechanism. Oral carbonic anhydrase inhibitors cause numerous systemic side effects such as metabolic acidosis and panting, diarrhea, vomiting, anorexia and others, all of which can be avoided with topical carbonic anhydrase inhibitors.
Dorzolamide Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Dorzolamide Hydrochloride manufacturers
- Product
- Dorzolamide Hydrochloride 130693-82-2
- Price
- US $0.00/g
- Min. Order
- 100g
- Purity
- 99.0%
- Supply Ability
- 10KG/month
- Release date
- 2021-07-03
- Product
- Dorzolamide Hydrochloride 130693-82-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-06-20
- Product
- Dorzolamide Hydrochloride 130693-82-2
- Price
- US $10.00/PCS
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2021-07-08